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FORSCHUNGSBERICHT 1996-1998


 

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Anatomisches Institut

Allgemeine Angaben:
Nussalle 10, 53115 Bonn, Telefon: 0228 / 73-2642, Telefax: 0228 / 73-3346

Hauptamtliche Professoren
Prof. Dr. med. Heinrich Büssow
Prof. Dr. med. Kurt Fleischhauer (emeritiert)
Prof. Dr. med. Thomas Franz
Prof. Dr. med. Karl Schilling (seit 1.4.1998; email: karl.schilling@uni-bonn.de; Tel. 0228-73-2602)
Prof. Dr. med. Hans-Martin Schmidt
Prof. Dr. med. Hubert Wartenberg (emeritiert)
Prof. Dr. med. Uwe Wulfhekel

Wissenschaftliches Personal
Universitätsstellen
Dr. med. Inge Kinsky (Akad. Oberrätin)
Dr. med. Thomas Koschek (Seit April 1999: Pathologisch-Anatomisches Institut der Universität Erlangen)
Dr. med. Michael Liebke (tätig bis 30.11.1998)
Dr. med. Georg H. Lüers
PD Dr. med. Andreas Miething (Akad. Oberrat)
PD Dr. med. Martina Maria Reidenbach (tätig bis 31.1.99)
PD Dr. med. Cordula Schmolke (tätig bis 31.10.98)
Dr. med. Peter Schwabedal
PD Dr. med. Christoph Viebahn

Drittmittelstellen
Nicole Jess (Bonfor)
Dipl. Biologe David-Marian Otte (Fritz Thyssen Stiftung)
Dipl.-Chem. Gunnar Weisheit (DFG)

Stipendiaten
PD Dr. Penka Pesheva (Bonfor)

Forschungsschwerpunkte
Elektronenmikroskopische Untersuchung des Myelins bei Mausmutanten
(Büssow)

Charakterisierung von Mausmutanten
(Franz, Lüers)

Induzierbare Promotersysteme
(Franz, Lüers)

Entwicklungsneurobiologie des Kleinhirns
(Kinsky, Koscheck, Schilling)

Biogenese von Peroxisomen
(Lüers, Otte)

Morphologische Untersuchung der Spermatogenese
(Miething)

Makroskopische Anatomie des Bewegungsapparates
(Schmidt)

Embryonale Frühentwicklung und Achsenbildung
(Viebahn, Weisheit)

Differenzierung embryonaler Keimzellen
(Viebahn)

Morphologische Untersuchung von Eisenstoffwechselstörungen
(Wulfhekel)

Besondere Forschungsförderung
Untersuchung der Pathogenese generalisierter peroxisomaler Erkrankungen und Analyse der Funktion von peroxisomalen Membranproteinen durch gezielten Gen-Knockout in Mäusen
(Lüers, Fritz Thyssen Stiftung)

Molecular and cellular mechanisms of cerebellar morphogenesis
(Schilling, Kinsky, Koscheck, Stier, NATO)

Zell-Zell-Interaktionen als Determinanten der neuronalen Differenzierung im Kleinhirn
(Schilling, Kinsky, Koscheck, Stier, DFG)

Die Entwicklung des Mesoderms beim Kaninchen: Morphologische Untersuchungen zur zellulären Differenzierung und molekularen Steuerung
(Viebahn, Liebke, DFG)

Die Achsenbildung des Säugers im phylogenetischen Vergleich: Konstitutionelle und funktionelle Analyse der Genexpression am Beispiel des Kaninchens
(Viebahn, Weisheit, DFG)

Veröffentlichungen
Bosio A, Bussow H, Adam J, Stoffel W:
Galactosphingolipids and axono-glial interaction in myelin of the central nervous system
Cell Tissue Res 1998; 292:199-210

Braumann B, Niederhagen B, Schmolke C, von Lindern JJ:
Dental assisted distraction osteogenesis of the mandible. Results of an animal experimental study and initial clinical application
Mund Kiefer Gesichtschir 1999; 3:6-11

Braumann B, Niederhagen B, Schmolke C:
Mandibular distraction osteogenesis. Preliminary results of an animal study with a dentally fixed distraction device
J Orofac Orthop 1997; 58:298-305

Faber KN,, Elgersma Y, Heyman JA, Koller A, Luers GH, Nuttley WM, Terlecky SR, Wenzel TJ, Subramani S:
Use of Pichia pastoris as a model eukaryotic system. Peroxisome biogenesis
Methods Mol Biol 1998; 103:121-47

Foerstner H, Schmidt HM:
Mano e dita
In: Grande Atlante di Tecnica Chirurgica, Cingolo Scapolare Arti Superiori. USES Edizioni Scientifiche, Firenze 1997 ISBN 88-02-05238-7

Hansis M, Schmidt HM:
Avambraccio ed articulatione del polso
In: Grande Atlante di Tecnica Chirurgica, Cingolo Scapolare Arti Superiori. USES Edizioni Scientifichi, Firenze 1997 ISBN 88-02-052387

Harbers K, Muller U, Grams A, Li E, Jaenisch R, Franz T:
Provirus integration into a gene encoding a ubiquitin-conjugating enzyme results in a placental defect and embryonic lethality.
Proc Natl Acad Sci U S A 1996; 93:12412-7.

Harris BS, Franz T, Ullrich S, Cook S, Bronson RT, Davisson MT:
Forebrain overgrowth (fog): a new mutation in the mouse affecting neural tube development.
Teratology 1997; 55:231-40.

Hempfling H, Schmidt HM:
Handgelenk
In: Chirurgische Operationslehre, Arthroskopie - obere und untere Extremität. Hrsg: Kremer K, Lierse W, Platzer W, Schreiber HW, Weller SG Thieme, Stuttgart 1998 ISBN 3-13-106991-0

Luers GH, Advani R, Wenzel T, Subramani S:
The Pichia pastoris dihydroxyacetone kinase is a PTS1-containing, but cytosolic, protein that is essential for growth on methanol.
Yeast 1998; 14:759-71.

Luers GH, Hartig R, Mohr H, Hausmann M, Fahimi HD, Cremer C, Volkl A:
Immuno-isolation of highly purified peroxisomes using magnetic beads and continuous immunomagnetic sorting.
Electrophoresis 1998; 19:1205-10.

Miething A.:
Degeneration of spermatocytes during meiotic divisions in the golden hamster testis.
J Submicrosc Cytol Pathol 1997; 29:29-35.

Miething A.:
Delayed onset of spermatid elongation in the pubertal golden hamster testis depends on a developmental deficiency of Leydig cell-11 beta-HSD.
Adv Exp Med Biol 1997; 424:159-60.

Miething A.:
The degenerative fate of germ cells not conforming to stage in the pubertal golden hamster testis.
J Anat 1998; 193:519-27.

Miething A.:
The establishment of spermatogenesis in the seminiferous epithelium of the pubertal golden hamster (Mesocricetus auratus).
Adv Anat Embryol Cell Biol 1998; 140:1-92.

Miething A:
Flat plastic embedding and precise longitudinal sectioning of isolated testicular seminiferous tubules.
Andrologia 1996; 28:343-7.

Monosov EZ, Wenzel TJ, Luers GH, Heyman JA, Subramani S:
Labeling of peroxisomes with green fluorescent protein in living P. pastoris cells.
J Histochem Cytochem 1996; 44:581-9.

Oberdick J, Baader SL, Schilling K:
From zebra stripes to postal zones: deciphering patterns of gene expression in the cerebellum.
TINS 1998; 21:383-391

Peeters MCE, Viebahn C, Hekking JWM, van Straaten HWM:
Neurulation in the rabbit embryo
Anat Embryol 1998; 197:167-175

Probstmeier R, Michels M, Franz T, Chan BM, Pesheva P:
Tenascin-R interferes with integrin-dependent oligodendrocyte precursor cell adhesion by a ganglioside-mediated signalling mechanism.
Eur J Neurosci 1999; 11:2474-88.

Reidenbach MM:
The attachments of the conus elasticus to the laryngeal skeleton: physiologic and clinical implications.
Clin Anat 1996; 9:363-70.

Reidenbach MM:
The cricothyroid space: topography and clinical implications
Acta Anat (Basel) 1996; 157:330-8.

Reidenbach MM:
The paraglottic space and transglottic cancer: anatomical considerations.
Clin Anat 1996; 9:244-51.

Reidenbach MM:
The periepiglottic space: topographic relations and histological organisation.
J Anat 1996; 188:173-82.

Reidenbach MM:
Anatomical considerations of closure of the laryngeal vestibule during swallowing.
Eur Arch Otorhinolaryngol 1997; 254:410-2.

Reidenbach MM:
Borders and topographic relations of the cricoid area.
Eur Arch Otorhinolaryngol 1997; 254:323-5.

Reidenbach MM:
Borders and topographic relationships of the paraglottic space.
Eur Arch Otorhinolaryngol 1997; 254:193-5.

Reidenbach MM:
Aryepiglottic fold: normal topography and clinical implications.
Clin Anat 1998; 11:223-35.

Reidenbach MM:
Subglottic region: normal topography and possible clinical implications.
Clin Anat 1998; 11:9-21.

Reidenbach MM:
The muscular tissue of the vestibular folds of the larynx.
Eur Arch Otorhinolaryngol 1998; 255:365-7.

Reidenbach MM:
Topographical anatomy and oncologic implications of the anterolateral surface of the arytenoid cartilage.
Eur Arch Otorhinolaryngol 1998; 255:140-2.

Reidenbach MM:
Anatomical bases of glottic widening surgery related to arytenoidectomy.
Clin Anat 1999; 12:94-102.

Schmidt HM, Schoonhoven van J, Lanz U:
Die knorpelig ligamentäre Zügelung des Ulnakopfes
Handchir Mikrochir Plast Chir 1998; 30:382-386.

Schmidt HM, Vahlensieck M:
Klinisch - radiologische Anatomie der Schulterregion
Radiologe 1996; 36:933 - 943.

Schmidt HM:
Chirurgische Anatomie des distalen Radioulnargelenkes und des ulnokarpalen Gelenkkompartimentes.
Handchir Mikrochir Plast Chir 1998; 30:346-350.

Schmolke C, Hugger A:
The human temporomandibular joint region in different positions of the mandible.
Anat Anz 1999; 181:61-4.

Schmolke C, Kunzle H:
On the presence of dendrite bundles in the cerebral cortex of the Madagascan lesser hedgehog tenrec and the red-eared pond turtle.
Anat Embryol (Berl) 1997; 196:195-213.

Schmolke C:
Tissue compartments in laminae II-V of rabbit visual cortex--three- dimensional arrangement, size and developmental changes.
Anat Embryol (Berl) 1996; 193:15-33.

Snyder WB, Faber KN, Wenzel TJ, Koller A, Luers GH, Rangell L, Keller GA, Subramani S:
Pex19p interacts with Pex3p and Pex10p and is essential for peroxisome biogenesis in Pichia pastoris.
Mol Biol Cell 1999; 10:1745-61.

Stoffel W, Boison D, Bussow H:
Functional analysis in vivo of the double mutant mouse deficient in both proteolipid protein (PLP) and myelin basic protein (MBP) in the central nervous system.
Cell Tissue Res 1997; 289:195-206.

Vahlensieck M, Schmidt HM, Schild H:
Neue Erkenntnisse zur makroskopischen Anatomie der Schulter: MRT und
Fortschr Röntgenstr 1996; 164:8.

Vahlensieck M, Wiggert E, Wagner U, Schmidt HM, Schild H:
Subacromial fat pad.
Surg Anat Radiol 1996; 18:33-36.

Viebahn C, Miething A, Wartenberg H:
Primordial germ cells of the rabbit are specifically recognized by a monoclonal antibody labelling the perimitochondrial cytoplasm.
Histochem Cell Biol 1998; 109:49-58.

Wagner UA, Vahlensieck M, Wiggert E, Schmidt HM, Schild H, Schmitt O:
Anatomische Studie des subakromialen Fettkörpers
Orthopädische Praxis 1997; 33:679-681.

Wartenberg H, Hilscher B, Hilscher W:
Germ cell kinetics during early ovarian differentiation: an analysis of the oogonial cell cycle and the subsequent changes in oocyte development during the onset of meiosis in the rat
Microsc.Res.Techniq. 1998; 40:377-397.

Wiemer EAC, Luers GH, Faber KN, Wenzel T, Veenhuis M, Subramani S:
Isolation and characterization of Pas2p, a peroxisomal membrane protein essential for peroxisome biogenesis in the methylotrophic yeast Pichia pastoris.
J Biol Chem 1996; 271:18973-80.

Wulfhekel U, Dullmann J:
Storage of iron in bone marrow plasma cells. Ultrastructural characterization, mobilization, and diagnostic significance.
Acta Haematol 1999; 101:7-15.


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