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FORSCHUNGSBERICHT 1996-1998


 

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Institut für Pharmakologie und Toxikologie

Allgemeine Angaben:
Reuterstrasse 2b, 53113 Bonn, Telefon: 0228 / 73-5410, Telefax: 0228 / 73-5404, eMail: pharmtox@ibm.rhrz.uni-bonn.de, WWW: http://www.uni-bonn.de/pharmakologie

Hauptamtliche Professoren
Prof. Dr. rer. nat. Heinz Bönisch
Prof. Dr. med. Manfred Göthert
Prof. Dr. rer. nat. Dieter Abbo Kalbhen
Prof. Dr. med. Kurt Racké

Wissenschaftliches Personal
Universitätsstellen
Dr. rer. nat. Michael Brüß
Prof. Dr. med. Robert Domenjoz
Priv.-Doz. Dr. med. Klaus Benno Fink
Dr. rer. nat. Rainer Hammermann
Dr. rer. nat. Donata Messeri
Priv.-Doz. Dr. med. Gerhard Josef Molderings
Prof. Dr. med. Eberhard Schlicker
Dr. rer. nat. Jürgen Steinmeyer
Dr. med. Gerd Wolf

Drittmittelstellen
Apotheker Michael Bühlen (SFB 400)
Diplom-Chemiker Rainer Hammermann (SFB 400)
Dr. rer. nat. Markus Kathmann (DFG)
Diplom-Chemikerin Sibylle Kiel (SFB 400)
Diplom-Biochemiker Wolfgang Meder (DFG)
Diplom-Chemiker Peter Pörzgen (Graduiertenkolleg)
Diplom-Biologe Fabian Runkel (SFB 400)
Diplom-Biologe Philipp Wiedemann (Graduiertenkolleg)

Stipendiaten

Forschungsschwerpunkte
Molekulare Neuropharmakologie
(Bönisch)

Neurotransmitter-Transporter und -Rezeptoren
(Bönisch)

Expression und Funktion präsynaptischer Kalziumkanäle nach zerebraler Ischämie und Epilepsie
(Fink)

Neuronale Apoptosemechanismen und Apoptosekaskade nach zerebraler Ischämie
(Fink)

Angriffspunkte und Wirkungsmechanismus von Anästhetika und Alkohol im ZNS
(Göthert)

Pharmakologische Eigenschaften von Serotoninrezeptoren und natürlich vorkommenden Varianten
(Göthert)

Auswirkungen von mechanischer Belastung auf Stoffwechsel und Morphologie des Gelenkknorpels und dessen pharmakologische Beeinflussung
(Kalbhen, Steinmeyer)

Charakterisierung der Wirkung von Arzneistoffen auf den anabolen und katabolen Metabolismus von Gelenkknorpel
(Kalbhen, Steinmeyer)

Bedeutung von Agmatin für die Pathogenese gastrointestinaler Läsionen
(Molderings)

Molekulare Identifizierung und Charakterisierung präsynaptischer Imidazolinrezeptoren
(Molderings)

Regulation und funktionelle Bedeutung von Stickstoff-Monoxid (NO)-Synthese in Zellen der Atemwege
(Racké, Hammermann)

Zelluläre und molekulare Pharmakologie der Atemwegsmucosa
(Racké, Hammermann)

Modulation der Serotonin- und Noradrenalinfreisetzung in Hirnschnitten von Tieren und des Menschen durch Serotonin-, Histamin- und Nociceptin-Rezeptoren
(Schlicker, Kathmann)

Pharmakologische und molekularbiologische Charakterisierung von Cannabinoid-CB1-Rezeptoren
(Schlicker, Kathmann)

Besondere Forschungsförderung
Molekulare Charakterisierung Antidepressiva-sensitiver Neurotransmitter-Transporter
(Bönisch, SFB 400, Teilprojekt A1)

Molekulare und funktionelle Charakterisierung der Promotorregion des Gens für den Antidepressiva-sensitiven Noradrenalin-Transporter
(Bönisch, Graduiertenkolleg GRK 246, Arbeitsgruppe 08)

Neurotransmitter-Systeme im menschlichen Gehirn als Angriffspunkte selektiver Neuropsychopharmaka
(Göthert, Bönisch, Schlicker, SFB 400, Teilprojekt A2)

Modifikation der Neurotransmitterfreisetzung als pathogenetische Grundlage von Funktionsstörungen des Nervensystems und als Wirkungsmechanismus von Neuro-Psychopharmaka
(Göthert, Schlicker, Graduiertenkolleg GRK 246, Arbeitsgruppe 01)

Pharmakologische Beeinflussung der NMDA-, Kainat- und 5-HT3-Rezeptor-vermittelten Neurotransmitterfreisetzung und Ionenflüsse
(Göthert, DFG Go 343/6)

Serotonin receptors and transporter: molecular, functional and therapeutic aspects
(Göthert, EG Biotechnology Project, BIO CT/96-0752/PL 960752)

Identifizierung, pharmakologische Charakterisierung und funktionelle Bedeutung von Imidazolinbindungsstellen und -rezeptoren
(Molderings, DFG MO 660/2-2)

Charakterisierung der Wirkung von Nikotin auf enterochromaffine Zellen und neuroendokrine Zellen der Atemwege
(Racké, Stiftung VERUM)

Control and pathophysiology of nitregic pathways in the airways
(Racké, DAAD, Vigoni-Programm)

Modulation des L-Arginin-Transportes in Alveolarmakrophagen und Epithelzellen der Atemwege und deren funktionelle Auswirkungen
(Racké, DFG)

Beeinflussung der Histamin- und Noradrenalinabgabe im Gehirn durch Histamin und Interleukin-1ß
(Schlicker, DFG, Schl 266/1-4)

Neurochemische und molekulare Grundlagen der Cannabinoidwirkung im Gehirn
(Schlicker, DFG Schl 266/5-1)

Entwicklung, Standardisierung und Prävalidierung eines in-vitro-Modells zum Ersatz von Tierversuchen in der Arthroseforschung: Biochemische und histologische Charakterisierung des Modells
(Steinmeyer, BMBF, TP 1)

Veröffentlichungen
Barann M, Bönisch H, Urban BW, Göthert M:
Inhibition of 5-HT3 receptor cation channels by ifenpropdil in excised patches of N1E-115 cells.
(1998) Naunyn-Schmiedeberg´s Arch Pharmacol 358: 145-152

Barann M, Göthert M, Bönisch H, Dybek A, Urban BW:
5-HT3 receptors in outside-out patches of N1E-115 neuroblastoma cells: basic properties and effects of pentobarbital.
(1997) Neuropharmacology 36, 655-664

Bönisch H, Eiden L:
Catecholamine reuptake and storage.
(1997) In: Goldstein DS, Eisenhofer G, McCarthy R: Catecholamines: Bridging basic science with clinical medicine, Academic Press, San Diego, London, Boston, New York, Sydney, Tokyo, Toronto

Bönisch H, Hammermann R, Brüss M:
Role of protein kinase C and second messengers in regulation of the norepinephrine transporter.
(1997) In: Goldstein DS, Eisenhofer G, McCarthy R: Catecholamines: Bridging basic science with clinical medicine, Academic Press, San Diego, London, Boston, New York, Sydney, Tokyo, Toronto

Bönisch H:
Transport and drug binding kinetics in membrane vesicle preparation.
(1998) Method Enzymol (Neurotransmitter Transporters; ed: S.G. Amara) 296: 259-278

Brunn G, Hey C, Wessler I, Racké K:
Endogenous nitric oxide inhibits leukotriene B4 release from rat alveolar macrophages.
(1997) Eur J Pharmacol 326:53-60

Brüss M, Bönisch H:
Anticancer therapy-induced emesis: existence of an intestinal subtype of the 5-HT3 receptor?
(1998) Gastroenterology 115: 1606-1607

Brüss M, Pörzgen P, Bryan-Lluka LJ, Bönisch H:
The rat norepinephrine transporter: molecular cloning from PC12 cells and functional expression.
(1997) Mol Brain Res 52:257-262

Bryan-Lluka LJ, Bönisch H:
Lanthanides inhibit the human noradrenaline, 5-hydroxytryptamine and dopamine transporters.
(1997) Naunyn-Schmiedeberg´s Arch Pharmacol 355:699-706

Bryan-Lluka LJ, James KM, Bönisch H, Pörzgen P, Guice KS, Oldham KT:
Catecholamine uptake and metabolism in rat lungs.
(1997) In: Goldstein DS, Eisenhofer G, McCarthy R: Catecholamines: Bridging basic science with clinical medicine, Academic Press, San Diego, London, Boston, New York, Sydney, Tokyo, Toronto

Bühlen M, Fink K, Böing C, Göthert M:
Evidence for presynaptic location of inhibitory 5-HT1Dß-like autoreceptors in the guinea-pig brain cortex.
(1996) Naunyn-Schmiedeberg's Arch Pharmacol 353:272-280

Burton L, Kippenberger A, Lingen B, Brüss M, Bönisch H, Christie DL:
A variant of the bovine noradrenaline transporter reveals the importance of the carboxy-terminal region for correct targeting to membrane and functional expression.
(1998) Biochem J 330:909-914

Fink K, Böing C, Göthert M:
Presynaptic 5-HT autoreceptors modulate N-methyl-D-aspartate-evoked 5-hydroxytryptamine release in the guinea-pig brain cortex.
(1996) Eur J Pharmacol 300:79-82

Fink K, Göthert M:
Both ethanol and ifenprodil inhibit NMDA-evoked release of various neurotransmitters at different, yet proportional potency: potential relation to NMDA receptor subunit composition.
(1996) Naunyn-Schmiedeberg's Arch Pharmacol 354:312-319

Freitag A, Reimann A, Wessler I, Racké K:
Effects of bacterial lipopolysaccharides (LPS) and tumor necrosis factor-a (TNF-a) on rat tracheal epithelial cells in culture: morphology, proliferation and induction of NO synthase.
(1996) Pulmonary Pharmacol 9:149-156

Freitag A, Wessler I, Racké K:
Adrenoceptor- and cholinoceptor-mediated mechanisms in the regulation of 5-hydroxytrytamine (5-HT) release from isolated tracheae of newborn rabbit.
(1996) Brit J Pharmacol 119:91-98

Freitag A, Wessler I, Racké K:
Nitric oxide via activation of guanylyl cyclase suppresses alpha2-adrenoceptor-mediated 5-hydroxytryptamine release from neuroendocrine epithelial cells of rabbit trachea.
(1997) Naunyn-Schmiedeberg's Arch Pharmacol 356:856-859

Freitag A, Wessler I, Racké K:
Phosphodiesterase inhibitors suppresses a2-adrenoceptor-mediated 5-hydroxytryptamine release from trachea of newborn rabbits.
(1998) Eur J Pharmacol 354:67-71

Giertz H, Flohe L, Göthert M, Peskar BA, Resch K:
Mediatoren der Entzündung und Allergie.
(1996) In: Allgemeine und spezielle Pharmakologie und Toxikologie, 7. Auflage (Hrsg.: W Forth, D. Henschler, W Rummel, K Starke), S. 319-362. Heidelberg Berlin Oxford: Spektrum Akademischer Verlag

Godlewski G, Malinowska B, Buczko W, Schlicker E:
Inhibitory H3 receptors on sympathetic nerves of the pithed rat: activation by endogenous histamine and operation in spontaneously hypertensive rats.
(1997) Naunyn-Schmiedeberg's Arch Pharmacol 355:261-266

Godlewski G, Malinowska B, Schlicker E, Bucher B:
Identification of histamine H3 receptors in the tail artery from normotensive and spontaneously hypertensive rats.
(1997) J Cardiovasc Pharmacol 29:801-807

Göthert M, Bönisch H, Schlicker E, Helmchen H:
Pharmakotherapie psychischer Erkrankungen.
(1996) In: Allgemeine und spezielle Pharmakologie und Toxikologie, 7. Auflage (Hrsg.: W Forth, D Henschler, W Rummel, K Starke), S. 285-312. Heidelberg Berlin Oxford: Spektrum Akademischer Verlag

Göthert M, Fink K, Fröhlich D, Likungu J, Molderings GJ, Schlicker E, Zentner J:
Presynaptic 5-HT auto- and heteroreceptors in the human central and peripheral nervous system.
(1996) Behav Brain Res 73:89-92

Göthert M, Molderings GJ:
Mibefradil- and w-conotoxin GVIA-induced inhibition of noradrenaline release from the sympathetic nerves of the human heart.
(1997) Naunyn-Schmiedeberg's Arch Pharmacol 356:860-863

Göthert M, Propping P, Bönisch H, Brüss M, Nöthen MM:
Genetic variation in human 5-HT receptors: potential pathogenetic and pharmacological role.
(1998) Ann New York Acad Sci 861:26-30

Göthert M, Schlicker E:
Regulation of 5-HT release in the CNS by presynaptic 5-HT autoreceptors and by 5-HT heteroreceptors.
(1997) In: Serotoninergic Neurons and 5-HT Receptors in the CNS, Handbook of Experimental Pharmacology, Band 129 (Hrsg.: HG Baumgarten, M Göthert), S. 307-350. Berlin Heidelberg New York Springer

Hammermann R, Bliesener N, Mössner J, Klasen S, Wiesinger H, Wessler I, Racké K:
Inability of rat alveolar macrophages to recycle L-citrulline to L-arginine despite induction of arginino-succinate synthetase mRNA and protein, and inhibition of nitric oxide synthesis by exogenous L-citrulline.
(1998) Naunyn-Schmiedeberg's Arch Pharmacol 358:601-607

Hammermann R, Warskulat U, Häussinger D:
Anisoosmotic regulation of the Mi-2 autoantigen mRNA in H4IIE rat hepatoma cells and primary hepatocytes.
(1998) FEBS Lett 435:21-24

Hara K, Yanagihara N, Minami K, Ueno S, Toyohia Y, Sata T, Kawamura M, Brüss M, Bönisch H, Shigematsu A, Izumi F:
Ketamine interacts with the noradrenaline transporter at a site partly overlapping the desipramine binding site.
(1998) Naunyn-Schmiedeberg´s Arch Pharmacol 358:328-333

Hey C, Boucher J-L, Vadon-Le Goff S, Ketterer G, Wessler I, Racké K:
Inhibition of arginase in rat and rabbit alveolar macrophages by N-omega-hydroxy-D,L-indospicine, effects on L-arginine utilization by nitric oxide synthase.
(1997) Br J Pharmacol 121:395-400

Kathmann M, Schlicker E, Marr I, Werthwein S, Stark H, Schunack W:
Ciproxifan and chemically related compounds are highly potent and selective histamine H3-receptor antagonists.
(1998) Naunyn-Schmiedeberg's Arch Pharmacol 358:623-627

Klapproth H, Racké K, Wessler I:
Acetylcholine and nicotine stimulate the release of granulocyte-macrophage colony stimulating factor from cultured human bronchial epithelial cells.
(1998) Naunyn-Schmiedeberg's Arch Pharmacol 357:472-475

Klapproth H, Reinheimer T, Metzen J, Münch M, Bittinger F, Kirkpatrick CJ, Höhle KD, Schemann M, Racké K, Wessler I:
Non-neuronal acetylcholine, a signalling molecule synthezised by surface epithelial cells of rat and man.
(1997) Naunyn-Schmiedeberg's Arch Pharmacol 355:515-523

Kristof RA, Clusmann H, Koehler W, Fink KB, Schramm J:
Treatment of accidental high dose intraventricularly Mezlocillin application by cerebrospinal fluid exchange.
(1998) J Neurol Neurosurg Psychiatry 64:379-381

Leurs R, Kathmann M, Vollinga RC, Menge WMPB, Schlicker E, Timmerman H:
Histamine homologues discriminating between two functional H3 receptor assays. Evidence for H3 receptor heterogeneity?
(1996) J Pharmacol Exp Ther 276:1009-1015

Likungu J, Molderings GJ, Göthert M:
Presynaptic imidazoline receptors and a2-adrenoceptors in the human heart: discrimination by clonidine and moxonidine.
(1996) Naunyn-Schmiedeberg's Arch Pharmacol 354:689-692

Malinowska B, Godlewski G, Bucher B, Schlicker E:
Cannabinoid CB1 receptor-mediated inhibition of the neurogenic vasopressor response in the pithed rat.
(1997) Naunyn-Schmiedeberg's Arch Pharmacol 356:197-202

Malinowska B, Godlewski G, Buczko W, Göthert M:
Facilitation by substance P and inhibition by (+)-tubocurarine of the 5-HT3 receptor-mediated Bezold-Jarisch reflex in rats.
(1996) Eur J Pharmacol 315:159-164

Malinowska B, Schlicker E:
Mediation of the positive chrono-tropic effect of CGP 12177 and cyanopindolol in the pithed rat by atypical ß-adrenoceptors, different from ß3-adreno-ceptors.
(1996) Brit J Pharmacol 117:943-949

Malinowska B, Schlicker E:
Further evidence for differences between cardiac atypical ß-adrenoceptors and brown adipose tissue ß3-adrenoceptors in the pithed rat.
(1997) Brit J Pharmacol 122:1307-1314

Meder W, Fink K, Göthert M:
Involvement of different calcium channels in K+- and veratridine-induced increases of cytosolic calcium concentration in rat cerebral cortical synaptosomes.
(1997) Naunyn-Schmiedeberg's Arch Pharmacol 356:797-805

Meyer J, Wiedemann P, Okladnova O, Brüss M, Staab T, Stöber G, Riederer P, Bönisch H, Lesch K-P:
Cloning and functional characterization of the human norepinephrine transporter gene promotor.
(1998) J Neural Transm 105:1341-1350

Molderings GJ, Donecker K, Burian M, Simon WA, Schröder DW, Göthert M:
Characterization of I2 imidazoline and sigma-binding sites in the rat and human stomach.
(1998) J Pharmacol Exp Ther 285:170-177

Molderings GJ, Frölich D, Likungu J, Göthert M:
Inhibition of noradrenaline release via presynaptic 5-HT1Da receptors in human atrium.
(1996) Naunyn-Schmiedeberg's Arch Pharmacol 353:272-280

Molderings GJ, Göthert M:
Effect of calcium channel blockers on noradrenaline release in the cardiovascular system.
(1998) Pharmacol Toxicol 83 Suppl I:84-86

Molderings GJ, Göthert M:
Imidazoline binding sites and receptors in cardiovascular tissue.
(1998) General Pharmacology 32:17-22

Molderings GJ, Göthert M:
Presynaptic imidazoline receptors mediate inhibition of noradrenaline release from sympathetic nerves in rat blood vessels.
(1998) Fund Clin Pharmacol 12:388-397

Molderings GJ, Likungu J, Göthert M:
Modulation of noradrenaline release from the synpathetic nerves of human atrial appendages by presynaptic EP3- and DP-receptors.
(1998) Naunyn-Schmiedeberg´s Arch Pharmacol 358:440-444

Molderings GJ, Likungu J, Jakschik J, Göthert M:
Presynaptic imidazoline receptors and non-adrenoceptor [3H]-idazoxan binding sites in human cardiovascular tissues.
(1997) Br J Pharmacol 122:43-50

Molderings GJ, Schmidt K, Bönisch H, Göthert M:
Inhibition of 5-HT3 receptor function by imidazolines in mouse neuroblastoma cells: potential involvement of sigma2 receptors.
(1996) Naunyn-Schmiedeberg's Arch Pharmacol 354:245-252

Molderings GJ:
Imidazoline receptors: basic knowledge, recent advances and future prospects for therapy and diagnosis.
(1997) Drugs Fut 22:757-772

Pörzgen P, Hammermann R, Bönisch H, Brüss M:
The human norepinephrine transporter gene contains multiple polyadenylation sites and two alternatively spliced C-terminal exons.
(1998) Biochim Biophys Acta 1398:365-370

Price GW, Burton MJ, Collin LJ, Duckworth M, Gaster L, Göthert M, Jones BJ, Roberts C, Watson JM, Middlemiss DN:
SB-216641 and BRL-15572 - compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors.
(1997) Naunyn Schmiedeberg's Arch Pharmacol 356:312-320

Racké J, Brunn G, Hey C, Wessler I:
Endogenous nitric oxide (NO) suppresses phospholipase A2 - lipoxygenase pathway in rat alveolar macrophages.
(1996) In: Biology of nitric oxyide (Hrsg.: Stammler JS, Gross SS, Moncada S) London, Portland Press, 110

Racké K, Freitag A, Wessler I:
Modulation of 5-hydroxytryptamine release from neuroendocrine cells of the airways by alpha- and beta-adrenoceptors and nicotine receptors.
(1997) Rend Atti Acad Sci Med Chir (Napoli), 150 (1997) 11-20.

Racké K, Hey C, Mössner J, Hammermann R, Stichnote Ch, Wessler I:
Activation of L-arginine transport by protein kinase C in rabbit, rat and mouse alveolar macrophages.
(1998) J Physiol 511:813-825

Racké K, Reimann A, Schwörer H, Kilbinger H:
Regulation of 5-hydroxytryptamine release from enterochromaffin cells.
(1996) Behav Brain Res 73:3-87

Racké K, Schwörer H, Kilbinger H:
Regulation of serotonin release from enterochromaffin cells.
(1996) In: Serotonin and the scientific basis of anti-emetic therapy (Hrsg.: Davis CJ, Andrews PLR, Reynolds DJM) Oxford, Clinical Communications 84-89

Racké K, Wessler I, Brunn G:
Nitric oxide and asthmatic inflammation.
(1996) Immunology Today 17:147-148

Reinheimer T, Baumgärtner D, Möhlig T, Racké K, Wessler I:
Acetylcholine inhibits histamine release from human isolated bronchi via stimulation of muscarinic receptors.
(1997) Am J Respir Crit Care Med 156:389-395

Reinheimer T, Bernedo P, Klapproth H, Oelert H, Zeiske B, Racké K, Wessler I:
Acetylcholine in isolated airways of rat, guinea-pig and man: species differences in the role of airway mucosa.
(1996) Am J Physiol Lung Cell Mol 14, L722-L728

Reinheimer T, Bittinger F, Eitel E, Racké K, Kirkpatrick CJ, Wessler I:
Glucocorticoid mediate reduction of epithelial acetylcholine in the airways of rat and man.
(1998) Eur J Pharmacol 49:277-284

Reinheimer T, Harnack E, Racké K, Wessler I:
Prostanoid receptors of the EP3 subtype mediate inhibition of evoked [3H]acetylcholine release from isolated human bronchi.
Br J Pharmacol 125:271-276

Schlicker E, Fink K, Kathmann M, Molderings GJ, Göthert M:
Effects of imidazolines on noradrenaline release in brain: an investigation into their relationship to imidazoline, a2 and H3 receptors.
(1997) Neurochem Int 30:73-83

Schlicker E, Fink K, Molderings GJ, Price GW, Duckworth M, Gaster L, Middlemiss DN, Zentner J, Likungu J, Göthert M:
Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors.
(1997) Naunyn-Schmiedeberg's Arch Pharmacol 356:321-327

Schlicker E, Fink K, Zentner J, Göthert M:
Presynaptic inhibitory serotonin autoreceptors in the human hippocampus.
(1996) Naunyn-Schmiedeberg's Arch Pharmacol 354:393-396

Schlicker E, Göthert M:
Interactions between the presynaptic alpha2-autoreceptor and presynaptic inhibitory heteroreceptors on noradrenergic neurones.
(1998) Brain Res Bull 47:129-132

Schlicker E, Kathmann M, Bitschnau H, Marr I, Reidemeister S, Stark H, Schunack W:
Potencies of antagonists chemically related to iodoproxyfan at histamine H3 receptors in mouse brain cortex and guinea-pig ileum: evidence for H3 receptor heterogeneity.
(1996) Naunyn-Schmiedeberg's Arch Pharmacol 353:482-488

Schlicker E, Kathmann M:
Modulation of in vitro neurotransmission in the CNS and in the retina via H3 heteroreceptors.
(1998) In: Leurs R, Timmerman H: The histamine H3 receptor as target for new drugs, Elsevier, Amsterdam

Schlicker E, Malinowska B:
Six histamine H1, H2 or H3 receptor-mediated effects in the cardiovascular system of pithed rats.
(1996) In: Tissue reactions in response to hypoxia and ischemia. Funktionsanalyse biologischer Systeme, Band 25 (Hrsg.: J Grote, C Stick), S. 83-89. Stuttgart Jena Lübeck Ulm: Gustav Fischer

Schlicker E, Marr I:
The moderate affinity of clozapine at H3 receptors is not shared by its two major metabolites and by structurally related and unrela-ted atypical neuroleptics.
(1996) Naunyn-Schmiedeberg's Arch Pharmacol 353:290-294

Schlicker E, Marr I:
Mutual interactions of the presynaptic histamine H3 and prostaglandin EP3 receptors on the noradrenergic terminals in the mouse brain.
(1997) Neuroscience 79:247-254

Schlicker E, Timm J, Göthert M:
Cannabinoid receptor-mediated inhibition of dopamine release in the retina.
(1996) Naunyn-Schmiedeberg's Arch Pharmacol 354:791-795

Schlicker E, Timm J, Zentner J, Göthert M:
Cannabinoid CB1 receptor-mediated inhibition of noradrenaline release in the human and guinea-pig hippocampus.
(1997) Naunyn-Schmiedeberg's Arch Pharmacol 356:583-589

Schlicker E, Werthwein S, Kathmann M, Bauer U:
Nociceptin inhibits noradrenaline release in the mouse brain cortex via presynaptic ORL1 receptors.
(1998) Naunyn-Schmiedeberg's Arch Pharmacol 358:418-422

Schmidt G, Racké K:
Gicht.
(1997) In: Hrsgb. G. Fülgraff & D. Palm, Pharmakotherapie, Klinische Pharmakologie. 10. Auflage Gustav Fischer Verlag, pp. 352-256.

Stark H, Schlicker E, Schunack W:
Developments of histamine H3-receptor antagonists.
(1996) Drugs Future 21:507-520

Steinmeyer J, Ackermann B, Raiss RX:
Intermittent cyclic loading of cartilage explants modulates fibronectin metabolism.
(1997) Osteoarthritis and Cartilage 5:331-341

Steinmeyer J, Daufeldt S, Kalbhen D:
Effects of the hydroxamine acid derivate Ro 31-4724 on the metabolism and morphology of interleukin-1 treated cartilage explants.
(1997) Pharmacology 55:95-108

Steinmeyer J, Daufeldt S, Kalbhen DA:
The proteoglycan metabolism, morphology and viability of articular cartilage treated with a synthetic matrix metallproteinase inhibitor.
(1997) Res Exp Med 197:63-79

Steinmeyer J, Daufeldt S, Taiwo YO:
Pharmacological effect of tetracyclines on proteoglycanases from interleukin-1-treated articular cartilage.
(1998) Biochem Pharmacol 55:93-100

Steinmeyer J, Daufeldt S:
Pharmacological influence of antirheumatic drugs on proteoglycanases from interleukin-1 treated articular cartilage.
(1997) Biochem Pharmacol 53:1627-1635

Steinmeyer J, Kalbhen DA:
The inhibitory effects of antirheumatic drugs on the activity of human leucocyte elastase and cathepsin G.
(1996) Inflamm Res 45:324-329

Steinmeyer J:
A computer-controlled mechanical culture system for biological testing of articular cartilage explants.
(1997) J Biomech 30:841-845

Stöber G, Nöthen MM, Pörzgen P, Brüss M, Bönisch H, Karpen M, Beckmann H, Propping P:
Systematic screening of the human norepinephrine transporter gene: Identification of five naturally occurring missense mutations and study of association with major psychiatric disorders
(1996) Am J Med Gen 67:523-537

Streich S, Brüss M, Bönisch H:
Expression of the extraneuronal monoamine transporter (uptake2) in human glioma cells.
(1996) Naunyn-Schmiedeberg's Arch Pharmacol 353:328-333

Timm J, Marr I, Werthwein S, Elz S, Schunack W, Schlicker E:
H2 receptor-mediated facilitation and H3 receptor-mediated inhibition of noradrenaline release in the guinea-pig brain.
(1998) Naunyn-Schmiedeberg's Arch Pharmacol 357:232-239

Wessler I, Kirkpatrick CJ, Racké K:
Non-neuronal acetylcholine, a locally acting molecule, widespreadly distributed in biological systems: Expression and function in man.
(1997) Pharmacol Therapeutic 77:1-21

Wessler I, Kirkpatrick CJ, Racké KR:
Non-neuronal acetylcholine, a locally acting molecule, widespreadly distributed in biological systems: Expression and function in man.
(1998) Pharmacology & Therapeutics 77:59-79

Wessler I, Reinheimer T, Klapproth H, Schneider FJ, Racké K, Hammer R:
Mammalian glial cells in culture synthesize acetylcholine.
(1997) Naunyn-Schmiedeberg's Arch Pharmacol 356:694-697


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