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FORSCHUNGSBERICHT 1996-1998


 

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Zentrum für Pathologie Institut für Neuropathologie

Allgemeine Angaben:
Sigmund-Freud-Straße 25, 53127 Bonn, Telefon: 0228 / 287-6523, Telefax: 0228 / 287-4331

Hauptamtliche Professoren
Prof. Dr. med. Andreas von Deimling (Stiftungsprofessor der Hermann und Lilly Schilling-Stiftung)
Prof. Dr. med. Guido Reifenberger (Stiftungsprofessor der Deutschen Krebshilfe)
Prof. Dr. med. Otmar D. Wiestler (Institutsdirektor)

Wissenschaftliches Personal
Universitätsstellen
Dr. med. Ingmar Blümcke
Dr. med. Oliver Brüstle
Priv.-Doz. Dr. med. Martina Deckert-Schlüter
Priv.-Doz. Dr. med. Torsten Pietsch
Priv.-Doz. Dr. med. Herbert Radner
Priv.-Doz. Dr. med. Helmut K. Wolf

Drittmittelstellen
Dr. rer. nat. Thomas Bayer (Fritz Thyssen Stiftung)
Dipl. Biol. Manuel Montesinos-Rongen (BONFOR)
Dipl. Biol. Iris Neidt (Deutsche Krebshilfe)
Dr. rer. nat. Britta Rollbrocker (Deutsche Krebshilfe)
Dr. rer. nat. Andreas Waha (SFB 400)
Dr. rer. nat. Anke Waha (SFB 400)
Dipl. Biol. Sascha Weggen (BONFOR)
Dr. rer. nat. Ruth Wellenreuther (DFG)

Stipendiaten
Dr. med. Albert Becker (DFG)
Dr. med. Volkmar Hans (BONFOR)
Priv.-Doz. Dr. med. Rita K. Schmutzler (DFG)

Forschungsschwerpunkte
Neuropathologie und Pathogenese von Temporallappen-Epilepsien
(Blümcke)

Neurobiologische und molekulare Charakterisierung von Stammzellen des Zentralnervensystems
(Brüstle)

Molekulare Pathogenese primärer ZNS-Lymphome
(Deckert-Schlüter)

Neuroimmunologie und Pathogenese der murinen Toxoplasma-Encephalitis
(Deckert-Schlüter)

Molekulare Charakterisierung von Hepatoblastomen
(Pietsch)

Molekulare Charakterisierung von Medulloblastomen
(Pietsch)

Transgene Modelle für metabolische Myopathien
(Radner)

Molekulare Charakterisierung von Meningeomen
(Reifenberger, von Deimling)

Hereditäres Mamma- und Ovarialcarcinom
(Schmutzler, Krebs, Propping, Nationales Verbundprojekt der Deutschen Krebshilfe)

Molekulargenetische Charakterisierung von Tumoren der Mamma
(Schmutzler)

Molekulare Charakterisierung von Gliomen
(von Deimling, Reifenberger)

Hirntumor-Referenzzentrum der Deutschen Gesellschaft für Neuropathologie und Neuroanatomie e.V.
(Wiestler)

Molekulare Diagnostik zentralnervöser Tumoren
(Wiestler)

Besondere Forschungsförderung
Molekulare Pathogenese SV40 large T Antigen-induzierter primitiver neuroektodermaler Tumoren
(, Bayer, BONFOR)

Quantitative RT-PCR Analyse von Neurotransmitter-Rezeptoren bei pharmako-resistenten Temporallappen-Epilepsien
(Becker, DFG-Forschungsstipendium)

Molekulare Neuropathologie fokaler Epilepsien
(Blümcke, Wiestler, Sonderforschungsbereich 400, Teilprojekt B6)

Neurale Stammzellen: Eine neue Perspektive für die Behandlung neurologischer Defizite
(Brüstle, Wiestler, Nachwuchsgruppenförderung aus dem Innovationsprogramm Forschung des Landes NRW)

Zellbiologische Charakterisierung und intracerebrale Transplantation in vitro generierter neuraler Vorläuferzellen
(Brüstle, BONFOR)

Molekularbiologische Analyse Progressions-assoziierter genetischer Alterationen in Meningeomen
(Büschges, Boström, BONFOR)

Regulation und Funktion von Mikrogliazellen bei der murinen Toxoplasma-Encephalitis
(Deckert-Schlüter, Wiestler, DFG-Schwerpunktprogramm Mikroglia)

Molekularbiologische Untersuchungen zur Pathogenese primärer Non-Hodgkin-Lymphome des Zentralnervensystems
(Deckert-Schlüter, BONFOR)

Immuntherapie maligner Hirntumoren – Etablierung eines Tumormodells in der Ratte und Evaluation einer Therapie mit bispezifischen Antikörpern in vitro und in vivo
(Hans, BONFOR)

Entwicklungskontrollgene und embryonale Tumoren des Kindesalters
(Pietsch, Bennigsen- Förder-Preis des Landes Nordrhein-Westfalen 1998)

Hämatopoietische Zytokine und humane Gliazellen: Bedeutung für die Pathophysiologie von Tumor-Erkrankungen des ZNS
(Pietsch, Deutsche Krebshilfe)

Molekulare Charakterisierung von Hepatoblastomen
(Pietsch, DFG)

Untersuchungen zur Bedeutung der Amplifikation und Überexpression zellulärer Onkogene in Glioblastomen
(Reifenberger, Sonderforschungsbereich 400, Teilprojekt C5)

Familiärer Brust- und Eierstockkrebs
(Schmutzler, Krebs, Propping, Schild, Wiestler, Nationales Verbundprojekt der Deutschen Krebshilfe)

Molekulargenetische Analyse von Tumoren der Mamma
(Schmutzler, DFG)

Molekulargenetische Untersuchungen an stereotaktisch gewonnenen Biopsaten
(von Deimling, Wiestler & externe Partner, Deutsche Krebshilfe)

Molekulare Charakterisierung von Gliomen
(von Deimling, Wiestler, Sonderforschungsbereich 400, Teilprojekt C1)

Molekulargenetische Analyse von Meningeomen
(von Deimling, Wiestler, DFG)

Molekulare Analyse von Hypophysenadenomen: Subklassifizierung von Hypophysenadenomen anhand spezifischer molekulargenetischer Charakteristika
(von Deimling, BONFOR)

Molekulare Entstehungsmechanismen von Gehirntumoren
(von Deimling, Schäfersnolte Gedächtnispreis des Landes NRW für neue Erkenntnisse der Krebsforschung)

Stiftungsprofessur für Medizinische Forschung
(von Deimling, Hermann und Lilly Schilling-Stiftung)

Molekulare Pathogenese des Medulloblastoms
(Wiestler, Pietsch, Sonderforschungsbereich 400, Teilprojekt C2)

Evaluation molekularer Diagnoseparameter für die maligne Progression niedriggradiger Astrocytome
(Wiestler, Schramm & externe Partner, Stiftung Neurochirurgische Forschung)

C3-Stiftungsprofessor für molekulare Neuroonkologie
(Wiestler, Deutschen Krebshilfe)

Pathogenese von Krankheiten des Nervensystems
(Wiestler, DFG-Graduiertenkolleg an der Universität Bonn, Teilprojekt 5)

Untersuchungen zur molekularen Pathogenese des Alzheimer A4 Amyloids im ZNS
(Wiestler, Fritz Thyssen Stiftung)

Zentrales Verwaltungsprojekt des Sonderforschungsbereichs 400
(Wiestler, DFG)

Pathogenese von fokalen, pharmakoresistenten Epilepsien des Menschen
(Wolf, Wiestler, DFG)

Veröffentlichungen
Albrecht S, Waha A, Koch A, Kraus J A, Goodyer CG, Pietsch T:
Variable imprinting of H19 and IGF2 in fetal cerebellum and medulloblastoma.
J Neuropath Exp Neurol 55 (1996), 1270-1276

Assaf N, Hasson T, Hoch-Marchaim H, Pe’er J, Gnessin H, Deckert-Schlüter M, Wiestler OD, Hochman J:
An experimental model for infiltration of malignant lymphoma to the eye and brain.
Virch Arch 431 (1997), 459-467

Bayer TA, Foßgreen A, Czech C, Beyreuther K, Wiestler OD:
Plaque formation in brain transplants exposed to human APP 695.
Acta Neuropathol 92 (1996), 130-137

Bayer TA, Paliga K, Weggen S, Wiestler OD, Beyreuther K, Multhaup G:
Amyloid precursor-like protein 1 accumulates in neuritic plaques in Alzheimer’s disease.
Acta Neuropathol 94 (1997), 519-524

Beck H, Blümcke I, Kral T, Clusmann H, Schramm J, Wiestler OD, Heinemann U, Elger CE:
Properties of a delayed rectifier potassium current in dentate granule cells isolated from the hippocampus of patients with chronic temporal lobe epilepsy.
Epilepsia 37 (1996), 892-901

Behrens E, Wolf HK, Hufnagel A, Zentner J, Elger CE, Schramm J: Funktionelle Hemisphärektomie bei therapieresistenter Epilepsie: operatives Vorgehen, Histopathologie und postoperatives Outcome. In: Meencke HJ (ed).:
Kongreßbericht vom 2. Symposium ”Epilepsiechirurgie in Deutschland” der Arbeitsgemeinschaft Epilepsiechirurgie vom 14. bis 20. November 1993 in Berlin,
(1996)

Bergmann M, Pietsch T, Herms J, Janus J, Spaar H-J:
Medullomyoblastoma: a histologic, immunohistochemical, ultrastructural and molecular genetic study.
Acta Neuropathol. 95 (1998), 205-212

Beyenburg S, Scheid B, Deckert-Schlüter M, Lagrèze HL:
Chronic progressive leukoencepalopathy in adult celiac disease.
Neurology 50 (1998), 820-822

Bierhoff E, Weiss A, Wolf HK, Ewig S, Rockstroh J, Pfeifer U:
Autopsy findings in patients with human immunodeficiency virus infection with emphasis on the risk factor of hemophilia.
Gen Diagnost Pathol 141 (1996), 295-304

Blümcke I, Beck H, Scheffler B, Hof PR, Morrison JH, Wolf HK, Schramm J, Elger CE, Wiestler OD:
Altered distribution of AMPA GluR2(4) and NMDAR1 receptor subunits in the hippocampus of patients with temporal lobe epilepsy.
Acta Neuropathol 92 (1996), 576-587

Blümcke I, Behle K, Malitschek B, Kuhn R, Knöpfel T, Wolf HK, Wiestler OD:
Immunohistochemical distribution of metabotropic glutamate receptor subtypes mGluR1b, mGluR2/3 and mGluR5 in human hippocampus.
Brain Res 736 (1996), 217-226

Blümcke I, Brockhaus A, Scheiwe C, Rollbrocker B, Wolf HK, Elger CE, Wiestler OD:
The apolipoprotein E e4 allele is not associated with early onset temporal lobe epilepsy.
NeuroReport 8 (1997), 1235-1237

Blümcke I, Eickhoff C, Beck H, Nitsch R, Scheffler B, Celio MR, Schramm J, Elger CE, Wolf HK, Wiestler OD:
Preservation of calretinin immunoreactive neurons in the hippocampus of patients with Ammon’s horn sclerosis.
J Neuropathol Exp Neurol 55 (1996), 329-341

Bokemeyer C, Kuczyk MA, Dunn T, Serth J, Hartmann K, Jonasson J, Pietsch T, Jonas U, Schmoll HJ:
Expression of stem-cell factor and ist receptor c-kit protein in normal testicular tissue and malignant germ-cell tumours.
J Cancer Res Clin Oncol 122 (1996), 301-306

Boström J, Cobbers JMJL, Wolter M, Tabatabai G, Weber RG, Lichter P, Collins VP, Reifenberger G:
Mutation of the PTEN (MMAC1) tumor suppressor gene in a subset of glioblastomas but not in meningiomas with loss of chromosome arm 10q.
Cancer Res 58 (1998), 29-33

Boström J, Mühlbauer A, Reifenberger G:
Deletion mapping of the short arm of chromosome 1 identifies a common region of deletion distal to D1S496 in human meningiomas.
Acta Neuropathologica 94 (1997), 479-485

Boström J, Mühlbauer A, Reifenberger G:
Deletionskartierung des kurzen Arms von Chromosom 1 in Meningeomen.
Verhandlungen der Deutschen Gesellschaft für Pathologie 81 (1997), 596

Brechtelsbauer DL, Urbach H, Sommer T, Blümcke I, Woitas R, Solymosi L:
Cytomegalovirus encephalitis and primary cerebral lymphoma mimicking Wernicke encephalopathy.
Neuroradiology 39 (1997), 19-22

Brüstle O, Choudhary K, Karram K, Hüttner A, Murray K, Dubois-Dalcq M, McKay RDG:
Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats.
Nature Biotechnology 16 (1998),1040-1044

Brüstle O, Cunningham M, Tabar V, Studer L:
Experimental transplantation in the embryonic, neonatal, and adult mammalian brain.
In: Crawley J, Gerfen C, McKay RDG, Rogawski M, Sibley D, Skolnick P: Current Protocols in Neuroscience, John Wiley, New York, 3.10.1-3.10.28 (1997).

Brüstle O, Spiro CA, Karram K, Choudhary K, Okabe S, McKay RDG:
In vitro-generated neural precursors participate in mammalian brain development.
Proc Natl Acad Sci USA 94 (1997), 14809-14814.

Bunzel R, Blümcke I, Cichon S, Normann S, Schramm J, Propping P, Nöthen MM:
Polymorphic imprinting of the serotonin-2A (5-HT2A) receptor gene in human adult brain.
Mol Brain Res 59 (1998), 90-2

Calaminus G, Janßen G, Lenard HG, Bock WJ, Reifenberger G, Schmitt G, Göbel U:
Combined therapy of medulloblastoma: Review of 46 patients treated in a single institution.
Neuropediatrics 29 (1998), 102-107

Campos MG, Ostertun B, Wolf HK, Zentner J, Hufnagel A, Elger CE, Schramm J:
Stellenwert der Magnet Resonanz Tomographie bei der Diagnostik der Ammonshornsklerose.
In: Meencke HJ (ed). Kongreßbericht vom 2. Symposium ”Epilepsiechirurgie in Deutschland” der Arbeitsgemeinschaft Epilepsiechirurgie vom 14. bis 20. November 1993 in Berlin, (1996)

Chou D, Miyashita T, Ueki K, Kastury K, Druck T, von Deimling A, Huebner K, Reed JC, Louis DN:
The BAX gene maps to chromosome 19q but is not altered in human gliomas.
Cancer Genet Cytogenet 88 (1996), 136-140

Cichon S, Nöthen MM, Wolf HK, Propping P:
Lack of imprinting of the human dopamine D4 receptor (DRD4) gene.
Am J Med Genet 67 (1996), 229-231

Cobbers JMJL, Wolter M, Reifenberger J, Ring GU, Jessen F, An HX, Niederacher D, Schmidt EE, Ichimura K, Floeth F, Kirsch L, Borchard F, Louis DN, Collins VP, Reifenberger G:
Frequent inactivation of CDKN2A and rare mutation of TP53 in PCNSL.
Brain Pathol 8 (1998), 263-276

Dahia PL, Fitzgerald MG, Zhang X, Marsh DJ, Zheng Z, Pietsch T, von Deimling A, Haluska FG, Haber DA, Eng C:
A highly conserved processed PTEN pseudogene is located on chromosome band 9p21.
Oncogene 16 (1998), 2403-2406

Deckert-Schlüter M, Blüthmann H, Rang A, Hof H, Schlüter D:
Crucial role of TNF receptor type 1 (p55), but not of TNF receptor type 2 (p75) in murine toxoplasmosis.
J. Immunol. 160 (1998), 3427- 3436

Deckert-Schlüter M, Buck C, Weiner D, Kaefer N, Rang A, Hof H, Wiestler OD, Schlüter D:
Interleukin-10 in the normal and Toxoplasma gondii-infected central nervous system.
J Neuroimmunol 76 (1997), 167-176

Deckert-Schlüter M, Marek J, Setlik M, Markova J, Pakos E, Fischer R, Wiestler OD:
Primary manifestation of Hodgkin´s disease in the central nervous system.
Vichows Arch. 432 (1998), 477- 481

Deckert-Schlüter M, Rang A, Weiner D, Huang S, Wiestler OD, Hof H, Schlüter D:
Interferon-_ receptor deficiency renders mice highly susceptible to toxoplasmosis by decreased macrophage activation.
Lab Invest 75 (1996), 827-841

Deckert-Schlüter M, Rang A, Wiestler OD:
Apoptosis and apoptosis-related gene products in primary non-Hodgkin’s lymphoma of the central nervous system.
Acta Neuropathol. 96 (1998), 157- 162

Deckert-Schlüter M:
Experimental toxoplasmosis: A paradigm to study systemic and intracerebral immune reactions.
Verh. Dtsch. Ges. Path. 82 (1998), 9-22

Deimling A von, Krone W:
Neurofibromatosis 1.
In: P. Kleihues and W. K. Cavenee: Pathology & Genetics: Tumours of the Nervous System, International Agency for Research on Cancer, Lyon, (1997)

Deimling A von, Wellenreuther R, Stangl AP, Wiestler OD:
Monoklonaler Ursprung multipler Meningeome.
Der Pathologe (im Druck), (1996)

Deimling A von:
Molecular genetic classification of astrocytic and oligodendroglial tumors.
Brain Pathol 7 (1997), 1311-1313

Deimling A von:
Differential patterns of molecular genetic alterations define subsets among glioblastomas and oligoastrocytomas.
Neuropathology 18 (1998),145-153

Deimling A von:
Molekularbiologie.
In: Schlegel, U. and M. Westphal (eds) Neuroonkologie, Georg Thieme Verlag, Stuttgart, 47-56 (1998)

Duerr EM, Rollbrocker B, Hayashi Y, Peters N, Meyer-Puttlitz B, Louis DN, Schramm J, Wiestler OD, Parsons R, Eng C, von Deimling A:
PTEN mutations in gliomas and glioneuronal tumors.
Oncogene 16 (1998), 2259-2264

Florian CL, Pietsch T, Noble MD, Williams SR:
Metabolic studies of human primitive neuroectodermal tumour cells by proton nuclear magnetic resonance spectroscopy.
Brit J Cancer 75 (1997), 1007-1013

Florian CL, Pietsch T, Williams SR, Noble MD:
Metabolic studies of human primitive neuroectodermal tumour cells by proton nuclear magnetic resonance spectroscopy.
Brit J Cancer (im Druck), (1996)

Fuchs J, Schmidt D, Pietsch T, Miller K, von Schweinitz D:
Successful transplantation of human hepatoblastoma into immunodeficient mice.
J Ped Surg 31 (1996), 1241-1246

Fulda S, Peter ME, Pietsch T, Debatin K-M:
Requirement for activation of the CD95 (APO-1/Fas) pathway in drug- and -irradiation-induced apoptosis in brain tumor cells.
Cell Death Differ. 5 (1998), 884-89

Giordana MT, Wiestler OD:
Medullomyoblastoma.
In: Pathology and genetics of tumors of the nervous system. Edited by P. Kleihues, W. Cavenee. International Agency for Research on Cancer, pp 104-105 (1997)

Haselsberger K, Radner H, Pendl G:
Boron neutron capture therapy for glioblastoma: improvement of boron biodistribution by hyaluronidase.
Cancer Lett 131 (1998), 109-111

Hayashi Y, Ueki K, Waha A, Wiestler OD, Louis DN, von Deimling A:
Association of EGFR gene amplification and CDKN2 (p16/MTS1) gene deletion in glioblastoma multiforme.
Brain Pathol 7 (1997), 871-875

Hermanson, M, Funa K, Koopmann J, Maintz D, Waha, Wiestler OD, Louis DN, von Deimling A, Nister M:
Association of loss of heterozygosity on chromosome 17p with high platelet derived growth factor a receptor expression in human malignant gliomas.
Cancer Res 56 (1996), 164-171

Hufnagel A, Elger CE, Pels H, Zentner J, Behrens E, Wolf HK Schramm J:
Prädilektionsfaktoren postoperativer Anfallsfreiheit nach anteriorer Temporallappenresektion.
In: Meencke HJ (ed). Kongreßbericht vom 2. Symposium ”Epilepsiechirurgie in Deutschland” der Arbeitsgemeinschaft Epilepsiechirurgie vom 14. bis 20. November 1993 in Berlin (im Druck), (1996)

Kleihues P, Kiessling M, Wiestler OD:
Zentrales Nervensystem (Kapitel 8)
In: PATHOLOGIE Böcker Denk Heitz (Hrsg.) Urban & Schwarzenberg, (1996)

Kleihues P, Kiessling M, Wiestler OD:
Tumoren des Nervensystems (Kapitel 9)
In: PATHOLOGIE Böcker Denk Heitz (Hrsg.) Urban & Schwarzenberg, (1996)

Kleihues P, Wiestler OD, Ohgaki H, Aguzzi A:
Animal Models of Tumors of the Nervous System.
In: Textbook of Gliomas Berger, M. and Wilson, Ch. (Eds.) W.B. Saunders, Cambridge, MA, (1996)

Koch A, Tonn J, Albrecht S, Sörensen N, Wiestler OD, Pietsch T:
Frequent intragenic polymorphism in the 3’ untranslated region of the lissencephaly gene 1 (LIS 1).
Clin Genet 50 (1996), 527-528

Koch A, Tonn J, Kraus J A, Sörensen N, Albrecht S, Wiestler OD, Pietsch T:
Molecular analysis of the lissencephaly gene 1 (LIS 1) in human medulloblastomas.
Neuropathol Appl Neurobiol 22, 233- 242

Kraus J A, Albrecht S, Wiestler OD, von Schweinitz D, Pietsch T:
Loss of heterozygosity on chromosome 1 in human hepatoblastoma.
Int J Cancer 67 (1996), 467-471

Kraus JA, Koch A, Albrecht S, von Deimling A, Wiestler OD, Pietsch T:
Loss of heterozygosity at the locus F13B on chromosome 1q in human medulloblastoma.
Int J Cancer 67 (1996), 11-15

Kraus JA, Koch A, Pietsch T:
Correspondence re: J. Benitez et al., A region of allelic imbalance in 1q31-32 in primary breast cancer coincides with a recombination hot spot.
Cancer Res. 58 (1998), 4480

Kühl J, Müller HL, Berthold F, Kortmann R-D, Deinlein F, Maaß E, Graf N, Gnekow A, Scheurlen W, Göbel U, Wolff JEA, Bamberg M, Kaatsch P, Kleihues P, Rating D, Sörensen N, Wiestler OD:
Preradiation chemotherapy of children and young adults with malignant brain tumors: Results of the German pilot trial HIT ‘88/’89
Klin. Pädiatr. 210 (1998), 227-233

Kunzelmann P, Blümcke I, Traub O, Dermietzel R, Willecke K:
Coexpression of connexin 45 and -32 in oligodendrocytes of rat brain.
J Neurocytol 26 (1997), 17-22

Lie AA, Blümcke I, Beck H, Wiestler OD, Elger CE:
Altered patterns of CA2+/calmodulin-dependent protein kinase II and calcineurin immunoreactivity in the hippocampus of patients with temporal lobe epilepsy.
J Neuropathol Exp Neurol 57 (1998), 1078-88

Lie AA, Schröder R, Blümcke I, Magin TM, Wistler OD, Elger CE:
Plectin in the human central nervous system: predominant expression at pia/glia and endothelia/glia interfaces.
Acta Neuropathol 96 (1998), 215-21

Louis DN, Budka H, von Deimling A:
Meningiomas.
In: P. Kleihues and W. K. Cavenee: Pathology & Genetics: Tumours of the Nervous System, International Agency for Research on Cancer, Lyon, (1997)

Louis DN, Neumann HPH, Menon AG, Short MP, Zbar B, von Deimling A:
The molecular genetic basis of hereditary tumor syndromes of the nervous system.
In: C. Raffel and G. R. Harsh: The Molecular Basis of Neurosurgical Disease, Williams and Wilkins, Baltimore, (1997)

Louis DN, Wiestler OD:
Neurofibromatosis type 2.
In: Pathology and genetics of tumors of the nervous system. Edited by P. Kleihues, W. Cavenee. International Agency for Research on Cancer, pp 175-178 (1997)

Mai JK, Krajewski S, Reifenberger G, Genderski B, Lensing-Höhn S, Ashwell KWS:
Spatiotemporal expression gradients of an adhesion molecule associated epitope (CD15) during development of the human basal ganglia.
Neuroscience 88 (1998), 847-858

Maintz D, Fiedler K, Koopmann J, Rollbrocker B, Nechev S, Lenartz D, Stangl AP, Louis DN, Schramm J, Wiestler OD, von Deimling A:
Molecular genetic evidence for subtypes of oligoastrocytomas.
J Neuropathol Exp Neurol 56 (1997), 1098-1104

Menon AG, Rutter JL, von Sattel JP, Snyder H, Murdoch C, Blumenfeld A, Martuza RL, von Deimling A, Gusella JF, Houseal TW:
Frequent loss of chromosome 14 in atypical and malignant meningioma: identification of a putative tumor progression locus.
Oncogene 14 (1997), 611-616

Merkel M, Kako YS, Radner H, Cho IS, Ramasamy R, Brunzell JD, Goldberg IJ, Breslow JL:
Catalytically inactive lipoprotein lipase expression in muscle of transgenic mice increases VLDL uptake. Direct evidence that LPL bridging occurs in vivo.
Proc Natl Acad Sci U S A 95 (1998), 13841-13846

Merkel M, Kako YS, Radner H, Cho IS, Ramasamy R, Brunzell JD, Goldberg IJ, Breslow JL:
Catalytically inactive lipoprotein lipase expression in muscle of transgenic mice increases VLDL uptake. Direct evidence that LPL bridging occurs in vivo.
Proc Natl Acad Sci U S A 95 (1998), 13841-13846

Merkel M, Weinstock PH, Chajek-Shaul T, Radner H, Yin B, Breslow JL, Goldberg IJ:
Lipoprotein lipase expression exclusively in liver: a mouse model for metabolism in the neonatal period and during cachexia.
J Clin Invest 102 (1998), 893-901

Meyer-Puttlitz B, Hayashi Y, Waha A, Rollbrocker B, Boström J, Wiestler OD, Louis DN, Reifenberger G, von Deimling A:
Molecular genetic analysis of giant cell glioblastomas.
Am J Pathol 151 (1997), 853-857

Mollenhauer J, Wiemann S, Scheurlen W, Korn B, Hayashi Y, Wilgenbus KK, von Deimling A, Poustka A:
DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours.
Nature Genet 17 (1997), 32-39

Nelson JS, von Deimling A, Janzer RC:
Metastatic tumours.
In: P. Kleihues and W. K. Cavenee: Pathology & Genetics: Tumors of the Nervous System, International Agency for Research on Cancer, Lyon, (1997)

Nemati NM, Stan AC, Pütz KM, Pietsch T, Walter GF, Dietz H:
Inhibition of angiogenesis and growth of malignant gliomas in the rat: immunotherapy with antibodies against basic fibroblast growth factor.
Zentralbl Neurochir 57 (1996), 12-19

Ohgaki H, Watanabe K, Peraud A, Nakazato Y, von Deimling A:
Giant cell Glioblastoma.
In: P. Kleihues and W. K. Cavenee: Pathology & Genetics: Tumours of the Nervous System, International Agency for Research on Cancer, Lyon, (1997)

Ostertun B, Wolf HK, Campos MG, Matus C, Solymosi L, Elger CE, Schramm J, Schild HH:
Dysembryoplastic neuroepithelial tumors (DNT): MR and CT evaluation.
Am J Neuroradiol 17 (1996), 419-430

Paulus W, Lisle DK, Tonn JC, Wolf HK, Roggendorf W, Reeves SA, Louis DN:
Molecular genetic alterations in pleomorphic xanthoastrocytoma.
Acta Neuropathol 91 (1996), 293-297

Peters N, Wellenreuther R, Rollbrocker B, Hayashi Y, Meyer-Puttlitz B, Dürr E-M, Lenartz D, Marsh DJ, Schramm J, Wiestler OD, Parsons R, Eng C, von Deimling A:
Analysis of the PTEN gene in human meningiomas.
Neuropathology and Applied Neurobiology 24:3-8 (1998)

Pietsch T, Fonatsch C, Albrecht S, Maschek H, Wolf HK, von Schweinitz D:
Characterization of the continuous cell line HepT1 derived from a human hepatoblastoma.
Lab Invest 74 (1996), 809-818

Pietsch T, Koch A, Wiestler OD:
Molecular genetic studies in medulloblastomas, Evidence for tumor suppressor genes at the chromosomal regions 1q31-32 and 17p13.
Klin Pädiatr 209 (1997), 150-155

Pietsch T, Nicotra MR, Fraioli R, Wolf HK, Mottolese M, Natali PG:
Expression of the c-kit receptor and its ligand SCF in non-small cell lung carcinomas.
Int. J. Cancer 75 (1998), 171-175

Pietsch T, Valter MV, Wolf HK, von Deimling A, Huang S, Cavenee WK, Wiestler OD:
Expression and distribution of vascular endothelial growth factor protein in human brain tumors.
Acta Neuropathol 93 (1997), 109-117

Pietsch T, Waha A, Koch A, Kraus J, Albrecht S, Tonn J, Sörensen N, Berthold F, Henk B, Schmandt N, Wolf HK, von Deimling A, Wainwright B, Chenevix-Trench G, Wiestler OD, Wicking C:
Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched.
Cancer Res 57 (1997), 2085-2088

Pietsch T, Wiestler OD:
Molecular neuropathology of astrocytic brain tumors.
J Neurooncol (im Druck), (1996)

Pietsch T, Wiestler OD:
Molecular neuropathology of astrocytic brain tumors.
J Neuro-Oncol 35 (1997), 211-222

Platten M, Meyer-Puttlitz B, Blümcke I, Waha A, Wolf HK, Nöthen M, Louis DN, Sampson JR, von Deimling A:
A novel splice site associated polymorphism in the tuberous sclerosis 2 (TSC2) gene may predispose to the development of sporadic gangliogliomas.
J Neuropath Exp Neurol 56 (1997), 806-810

Reifenberger G, Kros JM, Schiffer D, Collins VP:
Mixed gliomas.
In: Pathology and genetics of tumors of the nervous system. Edited by P. Kleihues, W. Cavenee. International Agency for Research on Cancer, pp 45-48 (1997).

Reifenberger G, Kros JM, Schiffer D, Collins VP:
Oligodendroglial tumors. In: Pathology and genetics of tumors of the nervous system.
Edited by P. Kleihues, W. Cavenee. International Agency for Research on Cancer, pp 38-44 (1997).

Reifenberger G, Ring GU, Reifenberger J, Wolter M, Jessen F, Cobbers JMJL, An HX, Niederacher D, Schmidt EE, Ichimura K, Floeth F, Kirsch L, Borchard F, Collins VP, Wechsler W:
Homozygote Deletionen des CDKN2A-Tumorsuppressorgens sind häufig in primären malignen Non-Hodgkin- Lymphomen des zentralen Nervensystems.
Verhandlungen der Deutschen Gesellschaft für Pathologie 81 (1997), 601

Reifenberger J, Janssen G, Weber RG, Boström J, Engelbrecht V, Lichter P, Borchard F, Göbel U, Lenard HG, Reifenberger G:
Primitive neuroectodermal tumors of the cerebral hemispheres in two siblings with TP53 germline mutation.
J Neuropathol Exp Neurol 57 (1998), 179-187

Reifenberger J, Wolter M, Weber RG, Megahed M, Ruzicka T, Lichter P, Reifenberger G:
Missense mutations in SMOH in sporadic basal cell carinomas of the skin and primitive neuroectodermal tumors of the central nervous system.
Cancer Res 58 (1998), 1798-1803

Rollbrocker B, Waha A, Louis DN, Wiestler OD, von Deimling A:
Amplification of the cyclin dependent kinase 4 (CDK4) gene is associated with high cdk4 protein levels in glioblastoma multiforme.
Acta Neuropathol 92 (1996), 70-74

Rosenberg JE, Lisle DK, Burwick JA, Ueki K, von Deimling A, Mohrenweiser HW, Louis DN:
Refined deletion mapping of the chromosome 19 glioma tumor suppressor gene to the D19S412-STD interval.
Oncogene 13 (1996), 2483-2485

Ruck P, Xiao J-C, Pietsch T, von Schweinitz D, Kaiserling E:
Hepatic stem-like cells in hepatoblastoma. Immunohistochemical and immuno-electronmicroscopic investigations with OV-1 and OV-6, and antibodies against cytokeratin 7 and albumin.
Histopathol 31 (1997), 324- 329

Ruck P, Xiao JC, Pietsch T, Kaiserling E:
Hepatic stem cells in the human liver.
Histopathol 29 (1996), 590-591

Schabet M, Martos M, Buchholz R, Pietsch T:
Animal model of human medulloblastoma: clinical, MR imaging, and histopathological findings after injection of MHH MED 1 cells into nude rats.
Med Ped Oncol (im Druck), (1996)

Schabet M, Martos M, Buchholz R, Pietsch T:
Animal model of human medulloblastoma: clinical, MR imaging, and histopathological findings after injection of MHH-MED-1 cells into nude rats.
Med Pediatr Oncol 29 (1997), 92-97

Scheffler B, Faissner A, Beck H, Behle K, Wolf HK, Wiestler OD, Blümcke I:
Hippocampal loss of tenascin boundaries in Ammon’s horn sclerosis.
Glia 19 (1996), 35-46

Scheffler B, Faissner A, Beck H, Behle K, Wolf HK, Wiestler OD, Blümcke I:
Hippocampal loss of tenascin boundaries in Ammon’s horn slcerosis.
Glia 19 (1997), 35-46

Schiffer D, Wiestler OD:
Ependymal tumors.
In: Pathology and genetics of tumors of the nervous system. Edited by P. Kleihues, W. Cavenee. International Agency for Research on Cancer, pp 49-56 (1997)

Schlegel U, Wiestler OD:
Neuroonkologie 2000 aus neurologisch neuropathologischer Sicht.
Onkologe 2 (1996), 53 57

Schlüter D, Bertsch D, Frei K, Hübers SB, Wiestler OD, Hof H, Fontana A and Deckert-Schlüter M:
Interferon-g antagonizes transforming growth factor-b2-mediated immunosuppression in murine toxoplasmosis.
J. Neuroimmunol. 81 (1998), 38-48

Schlüter D, Chahoud S, Lassmann H, Schumann A, Hof H, Deckert Schlüter M:
Intracerebral targets and immunomodulation of Listeria monocytogenes meningoencephalitis.
J Neuropathol Exp Neurol 55 (1996), 14-24

Schlüter D, Domann E, Buck C, Hain T, Hof H, Chakraborty T, Deckert-Schlüter M:
Phosphatidylcholine-specific phospholipase C from Listeria monocytogenes is an important virulence factor in murine cerebral listeriosis.
Inf. Immun. 66 (1998), 5930-5938

Schlüter D, Kaefer N, Hof H, Wiestler OD and Deckert-Schlüter M:
Expression pattern and cellular origin of cytokines in the normal and Toxoplasma gondii-infected murine brain.
Am J Pathol (im Druck), (1996)

Schlüter D, Kaefer N, Wiestler OD, Hof H, Deckert-Schlüter M:
Expression pattern and cellular origin of cytokines in the normal and T. gondii-infected brain.
Am J Pathol 150 (1997), 1021-1035

Schmutzler RK, Bierhoff E, Werkhausen T, Lohmar B, Homann A, Fimmers R, Kruse R, Speiser P, Kubista E, Krebs D, Zeilinger R, Wiestler OD, von Deimling A:
Genomic deletions in the BRCA1, BRCA2 and TP53 regions associate with low expression of the estrogen receptor in sporadic breast cancer.
Int J Cancer 74 (1997), 322-325

Schmutzler RK, Fimmers R, Bierhoff E, Lohmann B, Hohmann A, Zeilinger R, Krebs D, Wiestler OD, von Deimling A:
Association of allelic loss on chromosome 11q and 16q in sporadic breast cancer.
Int J Cancer 69 (1996), 307-311

Schröder R, Mudegar RR, Treusch M, Schlegel U, Blümcke I, Owaribe K, Magin TM:
Altered distribution of plectin/HD1 in dystrophinopathies.
Eur J Cell Biol 74 (1997), 165-171

Simon M, Kokkino AJ, Warnick RE, Tew Jr. JM, von Deimling A, Menon AG:
Role of genomic instability in meningioma progression.
Genes Chrom Cancer 16 (1996), 265-269

Stangl AP, Wellenreuther R, Benz M, Lenartz D, Kraus JA, Menon AG, Schramm J, Wiestler OD, von Deimling A:
Clonality of multiple meningiomas.
J Neurosurg (im Druck), (1996)

Stangl AP, Wellenreuther R, Lenartz D, Kraus JA, Menon AG, Schramm J, Wiestler OD, von Deimling A:
Clonality of multiple meningioma.
J Neurosurg 86 (1997), 853-858

Ueki K, Ono Y, Henson JW, von Deimling A, Louis DN:
CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated.
Cancer Res 56 (1996), 150 153

Urbach H, Behrens E, von Deimling A, Reul J:
Solides Kranipharyngeom im III. Ventrikel - Differentialdiagnostische Aspekte.
Akt. Radiol. 8 (1998), 95-97

Urbach H, Naujocks G, Wolf HK, Schultheiß R, Solymosi L:
Maligne Optikusgliome des Erwachsenenalters. Fallbericht und Literaturübersicht.
Klin Neuroradiol 6 (1996), 95-99

van Roost D, Kristof R, Zentner J, Wolf HK, Schramm J:
Clinical, radiological and therapeutic features of pleomorphic xanthoastrocytoma: report of 3 cases and review of the literature.
J Neurol Neurosurg Psychiat 60 (1996), 690-692

von Schweinitz D, Fuchs J, Glüer S, Pietsch T:
The occurence of liver growth factor in hepatoblastoma.
Eur. J. Pediatr. Surg. 8 (1998), 133-136

von Schweinitz D, Gluer S, Fuchs J, Pietsch T:
Hepatocyte growth factor in pediatric hepatoblastoma.
Langenbecks Arch Chir Suppl Kongressbd. 114 (1997), 37-40

von Schweinitz D, Leuschner I, Glüer S, Pietsch T:
Expression of cell adhesion molecules (CAMs) and common acute lymphoblastic leukemia antigen (CALLA) in hepatoblastoma.
Virch Arch 429 (1996), 235-241

Wagenknecht B, Trepel M, von Deimling A, Grimmel C, Rollbrocker B, Hayashi Y, Lang F, Dichgans J, Gulbins E, Weller M:
p53 acumulation promotes dephosphorylation and proteolytic cleavage of retinoblastoma protein in human malignant glioma cells.
Cell Physiol Biochem 7 (1997), 304-311

Waha A, Baumann A, Wolf HK, Fimmers R, Neumann J, Kindermann D, Major R, von Deimling A, Schlegel U:
Alterations in the EGF receptor/TGFa growth regulatory system are not of prognostic relevance in human astrocytic gliomas.
J Neurosurg 85 (1996), 634-641

Waha A, Rollbrocker B, Wiestler OD, von Deimling A:
A polymerase chain reaction based assay for the rapid detection of gene amplification in human tumors.
Diagnost Mol Pathol 5 (1996), 147-150

Waha A, Sturne C, Kessler A, Koch A, Kreyer E, Fimmers R, Wiestler OD, von Deimling A, Krebs D, Schmutzler RK:
Expression of the ATM gene is significantly reduced in sporadic breast carcinomas.
Int J Cancer 78 (1998), 306-309

Waha A, Watzka M, Koch A, Pietsch T, Przkora R, Peters N, Wiestler OD, von Deimling A:
A rapid and sensitive protocol for competitive reverse transcriptase (cRT) PCR analysis of cellular genes.
Brain Pathol. 8 (1998), 13-18

Watzka M, Waha A, Koch A, Schmutzler RK, Bidlingmaier F, von Deimling A, Klingmüller D, Stoffel-Wagner B:
An optimized protocol for mRNA quantification using nested competitive RT- PCR.
Biochemical and Biophysical Research Communications 231 (1997), 813-817

Weber RG, Boström J, Wolter M, Baudis M, Collins VP, Reifenberger G, Lichter P:
Analysis of genomic alterations in benign, atypical, and anaplastic meningiomas. Towards a genetic model of meningioma progression.
Proceedings of the National Academy of Sciences USA 94 (1997), 14719- 14724

Weber RG, Bridger JM, Benner A, Weisenberger D, Ehemann V, Reifenberger G, Lichter P:
Centrosome amplification as a possible mechanism for numerical chromosome aberrations in human primitive neuroectodermal tumors with mutant p53.
Cytogenet Cell Genet (im Druck) (1999)

Weber RG, Scheer M, Born IA, Joos S, Cobbers JMJL, Hofele C, Reifenberger G, Zöller JE, Lichter P:
Recurrent chromosomal imbalances detected in biopsy material from oral premalignant and malignant lesions by combined tissue microdissection, universal DNA amplification, and comparative genomic hybridization.
Am J Pathol 153 (1998), 295-303

Weggen S, Bayer TA, Koch A, Salewsky H, Scheidtmann K-H, Pietsch T, Wiestler OD:
Characterization of neural cell lines derived from SV40 large T-induced primitive neuroectodermal tumors.
Brain Pathol 7 (1997), 731-739

Weggen S, Diehlmann A, Buslei R, Beyreuther K, Bayer TA:
Prominent expression of presenilin-1 in senile plaques and reactive astrocytes in Alzheimer´s disease.
NeuroReport 9 (1998), 3279-3283

Weller M, Rieger J, Grimmel C, van Meir E, de Tribolet N, Krajewski S, Reed JC, von Deimling A, Dichgans J:
Predicting chemoresistance in human malignant glioma cells: the role of molecular genetic analyses.
Int J Cancer 79 (1998), 640-644

Weller M, Schuster M, Pietsch T, Schabet M:
CD95 ligand-induced apoptosis of human medulloblastoma cells.
Cancer Lett. 128 (1998), 121-126

Wick W, Petersen I, Schmutzler R, Wolfarth B, Lenartz D, Bierhoff E, Hümmerich J, Stangl AP, Schramm J, Wiestler OD, von Deimling A:
Evidence for a novel tumor suppressor gene on chromosome 15 associated with progression to a metastatic stage in breast cancer.
Oncogene 12 (1996), 973 978

Wicking C, Evans T, Henk B, Hayward N, Simms L A, Chenevix-Trench G, Pietsch T, Wainwright B:
No evidence for the H133Y mutation in SONIC HEDGEHOG in a collection of common tumour types.
Oncogene 16 (1998), 1091-1093

Wiestler OD, Chenevix-Trench G:
Naevoid basal cell carcinoma syndrome.
In: Pathology and genetics of tumors of the nervous system. Edited by P. Kleihues, W. Cavenee. International Agency for Research on Cancer, pp 193 (1997)

Wiestler OD, Kleihues P, Vital A, Padberg GW:
Cowden disease and Lhermitte-Duclos disease.
In: Pathology and genetics of tumors of the nervous system. Edited by P. Kleihues, W. Cavenee. International Agency for Research on Cancer, pp 188-190 (1997)

Wiestler OD, Lopez BS, Crino PB:
Tuberous sclerosis complex and subependymal giant cell astrocytoma.
In: Pathology and genetics of tumors of the nervous system. Edited by P. Kleihues, W. Cavenee. International Agency for Research on Cancer, pp 182-184 (1997)

Wiestler OD, Schmidt MC:
Neuropathologie maligner Gliome
Der Onkologe 4 (1998), 580-588

Wiestler OD:
Pathologische Anatomie und WHO-Klassifikation der Tumoren des Nervensystems.
In: Neuro-Onkologie, pp. 4-47 Schlegel, U. und Westphal, M. (Hrsg.) Georg Thieme Verlag (1998)

Wolf HK, Aliashkevich AF, Blümcke I, Wiestler OD, Zentner J:
Neuronal loss and gliosis of the amygdaloid nucleus in temporal lobe epilepsy. A quantitative analysis of 70 surgical specimens.
Acta Neuropathol 93 (1997), 606-610

Wolf HK, Blümcke I:
Pathological findings in mesial temporal sclerosis. In: Kotagal P, Lüders HO (eds) The epilepsies: etiologies and prevention.
Academic Press, New York, (1996)

Wolf HK, Buslei R, Blümcke I, Wiestler OD, Pietsch T:
Presence of neural antigens suggests a close relationship between oligodendrogliomas and dysembryoplastic neuroepithelial tumors.
Acta Neuropathol 94 (1997), 436-443

Wolf HK, Buslei R, Schmidt Kastner R, Schmidt Kastner PK, Pietsch T, Wiestler OD, Blümcke I:
NeuN a useful neuronal marker for diagnostic histopathology.
J Histochem Cytochem 44 (1996), 1167-1171

Wolf HK, Normann S, Green AJ, von Bakel I, Blümcke I, Pietsch T, Wiestler OD, von Deimling A:
Tuberöse Sklerose artige Läsionen in epileptogenem Neocortex weisen keinen Allelverlust im Bereich der TSC1 und TSC2 Regionen auf.
Verh Dtsch Ges Path: Vol. 80, (1996)

Wolf HK, Normann S, Green AJ, von Bakel I, Blümcke I, Pietsch T, Wiestler OD, von Deimling:
Tuberous sclerosis-like lesions in epileptogenic human neocortex lack allelic loss at the TSC1 and TSC2 regions.
Acta Neuropathol 93 (1997), 93-96

Wolf HK, Roos D, Blümcke I, Pietsch T, Wiestler OD:
Perilesional neurochemical changes in focal epilepsies.
Acta Neuropathol 91 (1996), 376-384

Wolf HK, Wiestler OD:
Die Neuropathologie chronischer pharmakoresistenter Epilepsien.
Dt Ärzteblatt 93 (1996), 2544-2547

Wolf, HK, Buslei R, Blümcke I B, Wiestler OD, Pietsch T:
Presence of neural antigens suggests a close relationship between oligodendrogliomas and dysembryoplastic neuroepithelial tumors.
J Neuropathol Exp Neurol (im Druck), (1996)

Wolter M, Reifenberger J, Ruzicka T, Reifenberger G:
Mutationen des PTCH-Tumorsuppressorgens in sporadischen Basaliomen und primitiven neuroectodermalen Tumoren.
Verhandlungen der Deutschen Gesellschaft für Pathologie 81 (1997), 169

Wolter M, Reifenberger J, Sommer C, Ruzicka T, Reifenberger G:
Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system.
Cancer Research 57 (1997), 2581-2585

Xuri Li X, Gray S, Flam F, Pietsch T, Ekström TJ:
Age-dependent DNA methylation of the IGF2 and H19 promoters is correlated to the promoter activities in the human liver development.
Int. J. Dev. Biol. 42 (1998), 687-695

Zannettino ACW, Aylett GW, Leavesley DI, Pietsch T, Chang DG, Simmons, PJ, Ashman LK:
Specificity and functional effects of antibodies to human steel factor.
Growth Factors 14 (1997), 67-79

Zannettino ACW, Aylett GW, Leavesley DI, Pietsch T, Simmons PJ, Ashman LK:
Specificity and functional effects of antibodies to human steel factor.
Growth Factors (im Druck), (1996)

Zentner J, Hufnagel A, Ostertun B, Wolf HK, Behrens E, Campos MG, Solymosi L, Elger CE, Wiestler OD, Schramm J:
Surgical treatment of extratemporal lobe epilepsy: clinical, radiological and histopathological findings in 60 patients.
Epilepsia (im Druck), (1996)

Zentner J, Hufnagel A, Pechstein U, Wolf HK, Schramm J:
Functional results after resective procedures involving the supplementary motor area.
J Neurosurg (im Druck), (1996)

Zentner J, Wolf HK, Ostertun B, Hufnagel A, Campos M, Wiestler OD, Elger CE, Schramm J.:
Klinische, radiologische und histopathologische Befunde bei 216 Patienten mit pharmakoresistenter Temporallappenepilepsie.
In: Meencke HJ (ed). Kongreßbericht vom 2. Symposium ”Epilepsiechirurgie in Deutschland” der Arbeitsgemeinschaft Epilepsiechirurgie vom 14. bis 20. November 1993 in Berlin, (1996)

Zogopoulos G, Albrecht S, Pietsch T, Alpert L, von Schweinitz D, Lefebvre Y, Goodyer CG:
Fetal and tumor specific regulation of growth hormone receptor messenger ribonucleic acid expression in human liver.
Cancer Res 56 (1996), 2949-2953


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