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FORSCHUNGSBERICHT 1996-1998


 

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Pharmazeutisches Institut Haus Endenich

Allgemeine Angaben:
An der Immenburg 4, 53121 Bonn, Telefon: 0228 / 73-5212, Telefax: 0228 / 73-7929, eMail: pharm.end@uni-bonn.de, WWW: www.pharma.uni-bonn.de/pharma/CHEMEND/index.htm

Hauptamtliche Professoren
Prof. Dr. rer. nat. Peter Gmeiner
Prof. Dr. rer. nat. Jochen Lehmann
Prof. Dr. rer. nat. Peter Nickel

Wissenschaftliches Personal
Universitätsstellen
Barko Bartkowski
Dr. Jan Josef Bolewski
Rüdiger Faust
Christian Haubmann
Dr. Matthias Kassack
Dr. Brigitte Mühlenbruch
Guido Müller
Matthias Oehlmann
Dr. Anja Radwansky
Prof. Dr. Erhard Röder (i.R.)
Joachim Schulz
Dr. Karl-Heinz Surborg
Dr. Helmut Wiedenfeld

Drittmittelstellen

Stipendiaten
Adolfo Andrade Cetto (DAAD)
Prof. Dr. Ali A. El-Emam (Alexander von Humboldt)
Prof. Dr. Hussein El-Subbagh (Alexander von Humboldt)

Forschungsschwerpunkte
Stereoselektive Synthese von ß-Aminosäuren
(Gmeiner)

Synthese, biologische Affinität und molekulares Design von selektiven Dopamin D-2 Autorezeptor Antagonisten
(Gmeiner)

NO-Donatoren
(Lehmann, Endres, Fonger, Kahlich, Weßler, Diewald)

Indole und verwandte N-Heterozyklen mit Affinität zum Dopamin-Rezeptor
(Lehmann, Faust, Rudolf, Schweikert, Schramm, Decker)

Chemotherapie von tropischen Krankheiten
(Nickel, Junker, Schulz, Kulik)

Synthese potentieller Chemotherapeutika: Aminochinoline (Malaria), Suramin-Analoge (Trypanosomiasis, Filariose, HIV, Zytostatika), Amoscanat-Analoge (Onchozerkose)
(Nickel, Müller, Simon, Junker, Oehlmann, Wandt)

Isolierung, Strukturaufklärung und Analytik von Naturstoffen; speziell: Pyrrolizidinalkaloide
(Röder, Wiedenfeld)

Phytochemische Untersuchungen an traditionellen Heilpflanzen Mexikos (Schwerpunkt: antidiabetische Wirkung)
(Wiedenfeld, Andrade Cetto)

Besondere Forschungsförderung

Veröffentlichungen
Bartkowski, J.-P. B., Wiedenfeld, H., Roeder, E.:
Quantitative photometric determination of senkirkine in farfarae folium
Phytochem. Anal. (1997), 8, 1-4

Bueltmann, R., Wittenburg, H., Pause, B., Kurz, G., Nickel, P., Starke, K.:
P2-purinoceptor antagonists. Part 3. Blockade of P2-purinoceptor subtypes and ecto-nucleotidases by compounds related to suramin
Naunyn-Schmiedeberg´s Arch. Pharmacol. (1996), 354, 498-504

Damer, S., Niebel, B., Czeche, S., Nickel, P., Ardanuy, U., Schmalzing, G., Rettinger, J., Mutschler, E., Lambrecht, G.:
NF279: a novel potent and selective antagonist of P2X receptor-mediated responses
Eur. J. Pharmacol (1998), 350, R5-R6

El-Emam, A.A., Lehmann, J.:
N- and S-alkylation of 3-(1-adamantyl)-4-methyl-1,2,4-triazole-5-thiol and 2-(1-adamantyl)-1,3,4-oxadiazole-5-thiol
Phosphorus, Sulfur Silicon Relat. Elem. (1997), 120 & 121, 473-474

Freissmuth, M., Boehm, S., Beindl, W., Nickel, P., Ijzermann, A.P., Hohenegger, M., Nanoff, C.:
Suramin analogs as subtype-selective G protein inhibitors
Mol. Pharmacol. (1996), 49, 602-11

Gagliardi, A. R. T., Kassack, M., Kreymeyer, A., Mueller G., Nickel, P., Collins, D. C.:
Antiangiogenic and antiproliferative activity of suramin analogs
Cancer Chemother. Pharmacol. (1998), 41, 117-124

Gmeiner, P., Bollinger, B., Lotter, H.:
Synthesis and stereochemistry of oxazolo[4´,5´:1,2]benz[5,4,3-c,d]indole derivatives as intermediates on the way to a selective dopamine autoreceptor antagonist
J. Heterocycl. Chem. (1996), 33, 481-483

Gmeiner, P., Kraxner, J., Bollinger, B.:
Diethoxymethyl protected indoles. Synthesis and regioselective transformations
J. Heterocycl. Chem. (1996), 33, 481-483

Gmeiner, P.:
Selective transformations of N,N-dibenzyl protected asparagine and aspartic acid derivatives
Enantiosel. Synth. .beta.-Amino Acids (1997), 67-81. Editor(s): Juaristi, Eusebio. Publisher: Wiley-VCH, New York, N.Y.

Hoesch, G., Wiedenfeld, H., Dingermann, Th., Röder, E.:
A new high performance liquid chromatography method for the simultaneous quantitative analysis of pyrrolizidine alkaloids and their N-oxides in plant material
Phytochem. Anal. (1996), 7, 284-288

Jones, R., Parry, R., Lo Leggio, L., Nickel, P.:
Inhibition of sperm-zons binding by suramin, a potential "lead" compound for design of new anti-fertility agents
Mol. Hum. Reprod. (1996), 2, 597-605

Kassack, M., Nickel, P.:
Rapid, highly sensitive gradient narrow-bore high-performance liquid chromatography determination of suramin and its analogs
J. Chromatogr., B: Biomed. Appl. (1996), 686, 275-284

Kassack, M., Nickel, P.:
Stability of suramin in aqueous solution; possible implications for the search of suramin metabolites in patients
Arch. Pharm. (Weinheim, Ger.) (1995), 329, 225-228

Kopp, B., Wawrosch, C., Lebada, R., Wiedenfeld, H.:
Pyrrolizidine alkaloid (PA) free coltsfoot leaves. Part 1. In vitro cultivation and selective breeding
Dtsch. Apoth. Ztg. (1997), 137, 4066-4069

Kreymeyer, A., Mueller, G., Kassack, M., Nickel, P., Gagliardi, A. R. T.:
Potential anti HIV- and angiostatic drugs. Part 2. Sulfanilic acid-, benzenedisulfonic acid-, and naphthalenetrisulfonic acid analogs
Arch. Pharm (Weinheim, Ger.) (1998), 331, 97-103

Lehmann, J., Kahlich, R., Meyer zum Gottesberge, C., Fricke, U.:
Organic nitrates. Part 2. Synthesis and biological activities of 4-[(nitrooxymethyl)phenyl]-1,4-dihydropyridines
Arch. Pharm. (Weinheim, Ger.) (1997), 330, 247-252

Lehmann, J., Kahlich, R., Meyer, C., Schulte, A., Stephan, K.:
Synthesis and biological activity of nitrooxymethyl- and nitrooxyacyloxy-phenyl-1,4-dihydropyridines
Portland Press. Proc. (1998), 15 (Biology of Nitric Oxide, Part 6), 294,

Lehmann, Jochen:
Organic nitrates. New perspectives for an old pharmaceutical group
Pharm Unserer Zeit (1998), 27, 52-57

Liu, Ke, Röder, E.:
Isolation and identification of pyrrolizidine alkaloids from amber groundsel (Senecio ambraceus)
Zhongcaoyao (1996), 27, 203-205

Morty, R. E., Troeberg, L., Pike R. N., Jones, R., Nickel, P., Lonsdale-Eccles, J. D., Coetzer, T. H. T.:
A trypanosome oligopeptidase as a target for the trypanocidal agents pentamidine, diminazene and suramin
FEBS Lett. (1998), 433, 251-256

Röder, E., Eckert, A., Wiedenfeld, H.:
Pyrrolizidine alkaloids from Gynura divaricata
Planta Med. (1996), 62, 386

Wernery, U., Bourauel, T., Röder, E., Meier, U., Wiedenfeld, H.:
Toxic diterpene glycosides from Iphiona aucheri
Fitoterapia (1997), 68, 278-280

Wiedenfeld, H., Andrade Cetto, A.:
Pyrrolizidine alkaloids from Critonia morifolia
Phytochemistry (1998), 49, 1463-1465

Wiedenfeld, H., Furmanowa, M., Röder, E., Guzewska, J., Gustowski, W.:
Camptothecin and 10-hydroxycamptothecin in callus and plantlets of Camptotheca accuminata
Plant Cell, Tissue Organ Cult. (1997), 49, 213-218

Wiedenfeld, H., Röder, E., Luck, W.:
O7-Angeloylretronecine, a pyrrolizidine alkaloid from Senecio inornatus
Planta Med. (1996), 62, 483

Wiedenfeld, H.:
Pyrrolizidine alkaloid (PA) free coltsfoot leaves. Part 2. Analysis of pyrrolizidine alkaloids
Dtsch. Apoth. Ztg. (1997), 137, 4070-71, 4074-75

Ziyal, R., Ziganshin, A., Nickel, P., Ardanuy, U., Mutschler, E., Lambrecht, G., Burnstock, G.:
Vasoconstrictor responses via P2X-receptors are selectively antagonized by NF023 in rabbit isolated aorta and saphenous artery
Br. J. Pharmacol. (1997), 120, 954-960

Zündorf, I., Wiedenfeld, H., Roeder, E., Dingermann, Th.:
Generation and characterization of monoclonal antibodies against the pyrrolizidine alkaloid retrorsine
Planta Med. (1998), 64, 259-263


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