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FORSCHUNGSBERICHT 1999-2001

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Anatomisches Institut

Allgemeine Angaben:
Nussalle 10, 53115 Bonn
Telefon: 0228 / 73-2642, -2647
Fax: 0228 / 73-3346, -7301

Hauptamtliche Professoren:
Prof. Dr. med. Heinrich Büssow
Prof. Dr. med. Kurt Fleischhauer emeritiert
Prof. Dr. med. Thomas Franz email: umv206@uni-bonn.de; Tel.0228/73-2601,-2642
Prof. Dr. med. Karl Schilling email: karl.schilling@uni-bonn.de; Tel. 0228/73-2602, -2647
Prof. Dr. med. Hans-Martin Schmidt
Prof. Dr. med. Hubert Wartenberg emeritiert
Prof. Dr. med. Uwe Wulfhekel

Wissenschaftliches Personal:
Universitätsstellen
PD Dr. rer.nat Stephan Baader
Dr. rer. nat. Alexander Borowski
Dipl.-Biol. Martin Holst
Dr. med. Inge Kinsky Akad. Oberrätin
AiP Felix Koch
Dr. rer. nat. Elke Lamp
Dipl.-Biol. Christian Liebig
Dr. med. Georg H. Lüers
PD Dr. med. Andreas Miething Akad. Oberrat
PD Dr. med. Martina Maria Reidenbach tätig bis 31.1.99
Dr. rer. nat. Fabian Runkel
Dr. med. Peter Schwabedal
PD Dr. med. Christoph Viebahn tätig bis 01.03.2000
Dipl. Chem. Gunnar Weisheit

Drittmittelstellen
Nicole Jess (Bonfor)
Daniela Lind (DFG-Graduiertenkolleg)
Kirsten Mertz (DFG)
Dipl. Biologe David-Marian Otte (Fritz Thyssen Stiftung)
Ulrich Schüller (DFG-Graduiertenkolleg)
Dr. med. vet. Gabriele Spatkowski (DFG)
Tim-Oliver Vilz (DFG-Graduiertenkolleg)
Anja Weyer (DFG-Graduiertenkolleg)

Forschungsschwerpunkte:
Elektronenmikroskopische Untersuchung des Myelins bei Mausmutanten
(Büssow)

Morphologische Untersuchungen zur Ontogenese der Epidermis bei transgenen Mäusen
(Büssow)

Charakterisierung von Mausmutanten
(Franz, Lüers)

Induzierbare Promotersysteme
(Franz, Lüers)

Genetische Grundlagen der neuronalen Differenzierung im Kleinhirn
(Holst, Liebig, Baader)

Entwicklungsneurobiologie des Kleinhirns (Aktuelle Info s. http://www.meb.uni-bonn.de/anatomie/cellbio/index.html)
(Kinsky, Koscheck, Schilling)

Genetische Grundlagen zum Aufbau neuronaler Netzwerke
(Liebig, Holst, Baader)

Biogenese von Peroxisomen
(Lüers, Otte)

Morphologische Untersuchung der Spermatogenese
(Miething)

Makroskopische Anatomie des Bewegungsapparates
(Schmidt)

Differenzierung embryonaler Keimzellen
(Viebahn)

Embryonale Frühentwicklung und Achsenbildung
(Viebahn, Weisheit)

Morphologische Untersuchung von Eisenstoffwechselstörungen
(Wulfhekel)

Besondere Forschungsförderung:
Die Achsenbildung des Säugers im phylogenetischen Vergleich: Konstitutionelle und funktionelle Analyse der Genexpression am Beispiel des Kaninchens
(Viebahn, Weisheit, DFG)

Die Entwicklung des Mesoderms beim Kaninchen: Morphologische Untersuchungen zur zellulären Differenzierung und molekularen Steuerung
(Viebahn, Liebke, DFG)

Molecular and cellular mechanisms of cerebellar morphogenesis
(Schilling, Kinsky, Koscheck, Stier, NATO)

Potentielle Zielgene von Engrailed-2
(Holst, Liebig, Baader, BONFOR)

Untersuchung der Pathogenese generalisierter peroxisomaler Erkrankungen und Analyse der Funktion von peroxisomalen Membranproteinen durch gezielten Gen-Knockout in Mäusen
(Lüers, Fritz Thyssen Stiftung)

Zell-Zell-Interaktionen als Determinanten der neuronalen Differenzierung im Kleinhirn
(Schilling, Kinsky, Koscheck, Stier, DFG)

Veröffentlichungen:

Baader, S.L., Bergmann, M., Mertz, K., Fox, P.A., Gerdes, J., Oberdick, J., Schilling, K.
The differentiation of cerebellar interneurons is independent of their mitotic history.
Neuroscience 90, 1243-1254 (1999)

Baader, S.L., Vogel, M.W., Sanlioglu, S., Zhang, X., Oberdick, J.
Selective disruption of "late onset" sagittal banding patterns by ectopic expression of engrailed-2 in cerebellar Purkinje cells.
J Neurosci 19, 5370-5379 (1999)

Campione, M., Steinbeisser, H., Schweickert, A., Deissler, K., van Bebber, F., Lowe, L.A., Nowotschin, S., Viebahn, C., Haffter, P., Kuehn, M.R., Blum, M.
The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping.
Development 126, 1225-1234 (1999)

Chu, T., Hullinger, H., Schilling, K., Oberdick, J.
Spatial and temporal map of natural and target deprivation-induced cell death in the mouse inferior olive.
J. Neurobiol. 43, 18-30 (2000)

Henkel-Kopleck, A., Schmidt, H.M.
Das Ligamentum metacarpale pollicis.
Handchir Mikrochir Plast Chir 32, 223-230 (2000)

Henkel-Kopleck, A., Schmidt, H.M.
[The Architecture of the Fibrous Complex between the Palmar Aponeurosis and the Flexor Retinaculum].
Handchir Mikrochir Plast Chir. 33, 294-8 (2001)

HenkelKopleck, A., Schmidt, HM
The metacarpal ligament of the thumb. Topography and functional significance of a heretofore unknown fiber tract of the thumb and its anatomic relationship to the internal interosseus muscle
Handchirurgie, Mikrochirurgie, Plastische Chirurgie 32 (4), 223-230 (2000)

Hesse, M., ,Franz,T.,Tamai,Y.,Taketo,M.M.,Magin,T.M., Franz, T., Tamai, Y., Taketo, M.M., Magin, T.M.
Targeted deletion of keratins 18 and 19 leads to trophoblast fragility and early embryonic lethality.
EMBO J. 19, 5060-5070 (2000)

Hue, I., Renard, J.P., Viebahn, C.
Brachyury is expressed in gastrulating bovine embryos well ahead of implantation
Dev. Genes Evol. 211, 157-159 (2001)

Knoetgen, H., Teichmann, U., Wittler, L., Viebahn, C., Kessel, M.
Anterior neural induction by nodes from rabbits and mice.
Dev Biol 225, 370-380 (2000)

Knoetgen, H., Viebahn, C., Kessel, M.
Head induction in the chick by primitive endoderm of mammalian, but not avian origin
Development 126 (4), 815-825 (1999)

Lamp, E.C., Drexler, H.G.
Biology of tartrate-resistant acid phosphatase.
Leuk Lymphoma 39, 477-484 (2000)

Liptau, H., Viebahn, C.
Expression patterns of gap junctional proteins connexin 32 and 43 suggest new communication compartments in the gastrulationg rabbit embryo
Differentiation 65, 209-219 (1999

Lluch, A., Hooper, G., Kapandji, A., Lanz, U., Schmidt, H.-M., Leslie, I.
Terminology for Hand Surgery
Int. Fed. of Societies for Surgery of the Hand, 1-113 (2001)

Lommel, S., Benesch, S., Rottner, K. , Franz, T., Wehland, J., Kühn, R.
Actin Pedestal Formation by Enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N-WASP-defective cells.
EMBO Reports 2, 850-857 (2001)

Luers, G.H., Jess, N., Franz, T.
Reporter-linked monitoring of transgene expression in living cells using the ecdysone-inducible promoter system
Eur. J. Cell Biol. 79, 653-657 (2000)

Luers, G.H., Otte, D.M., Subramani, S., Franz, T.
Genomic organization, chromosomal localization and tissue specific expression of the murine Pxmp2 gene encoding the 22 kDa peroxisomal membrane protein (Pmp22).
Gene 272, 45-50 (2001)

Mertz, K., Koscheck, T., Schilling, K.
Brain derived neuronotrophic factor modulates dendritic morphology of cerebellar basket and stellate cells.
Neuroscience 97, 303-310 (2000)

Mertz, K., Schilling, K.
Differentiation and morphogenesis of cerebellar interneurons developing under controlled in vitro conditions.
Ann Anat.183, 389-90 (2001)

Niederhagen, B., Braumann, B., Schmolke, C., Appel, T., von Lindern, JJ., Berge, S.
Tooth-borne distraction of the mandible - An experimental study
International Journal of Oral and Maxillofacial Surgery 28 (6), 475-479 (1999)

Peters, B., Kirfel, J., Bussow, H., Vidal, M., Magin, T.M.
Complete cytolysis and neonatal lethality in keratin 5 knockout mice reveal its fundamental role in skin integrity and in epidermolysis bullosa simplex.
Mol. Biol. Cell 12, 1775-1789 (2001)

Probstmeier, R., Michels, M., Franz, T., Chan, B.M., Pesheva, P.
Tenascin-R interferes with integrin-dependent oligodendrocyte precursor cell adhesion by a ganglioside-mediated signalling mechanism.
Eur. J. Neurosci. 11, 2474-2488 (1999)

Reichelt, J., Bussow, H., Grund, C., Magin, T.M.
Formation of a normal epidermis supported by increased stability of keratins 5 and 14 in keratin 10 null mice.
Mol. Biol. Cell 12, 1557-1568 (2001)

Reidenbach, MM.
Anatomical bases of glottic widening surgery related to arytenoidectomy
Clinical Anatomy 12 (2), 94-102 (1999)

Rex-Mathes, M., Werner, S., Strutas, D, ,Griffith, L.S.,Viebahn, C.,Thelen, K.,Schmitz, B., Griffith, L.S., Viebahn, C., Thelen, K., Schmitz, B.
O-GlcNAc expression in developing and ageing mouse brain.
Biochimie 83, 583-90 (2001)

Schäfer-Haas, A., Viebahn, C.
The germ cell epitope PG-2 is expressed in primordial germ cells and in hypoblast cells of the gastrulating rabbit embryo.
Anat. Embryol. 202, 13-23 (2000)

Schilling, K.
Lineage, development, and morphogenesis of cerebellar interneurons.
Prog. Brain Res. 124, 51-68 (2000)

Schilling, K.
Nervengewebe und Nervensystem.
In: Gratzl, M: Junqueira, Carneiro, Kelly: Histologie, Springer, Berlin, 107-141 (2001)

Schmidt, H.M., Fischer, G.
[Pulleys of the tendon sheath of the flexor pollicis longus muscle].
Handchir. Mikrochir. Plast. Chir 31, 362-366 (1999)

Schmidt, HM.
Functional anatomy and biomechanics of the wrist joint
Kongressband/Deutsche Gesellschaft für Chirurgie 118, 399-401 (2001)

Schmolke, C., Hugger, A.
The human temporomandibular joint region in different positions of the mandible
Anatomischer Anzeiger 181 (1), 61-64 (1999)

Schüller, U., Lamp, E.C., Schilling, K.
Developmental expression of heterotrimeric G-proteins in the murine cerebellar cortex.
Histochem Cell Biol.116, 149-59 (2001)

Sutor, B., Schmolke, C., Teubner, B., Schirmer, C., Willecke, K.
Myelination defects and neuronal hyperexcitability in the neocortex of connexin 32-deficient mice
Cerebral Cortex 10 (7), 684-697 (2000)

Teubner, B., Odermatt, B., Guldenagel, M., Sohl, G., Degen, J., Bukauskas, F.F., Kronengold, J., Verselis, V.K., Jung, Y.T., Kozak, C.A., Schilling, K., Willecke, K.
Functional Expression of the New Gap Junction Gene Connexin47 Transcribed in Mouse Brain and Spinal Cord Neurons.
J Neurosci 21, 1117-1126 (2001)

Uschkureit, T., Sporkel, O., Bussow, H., Stoffel, W.
Rumpshaker-like proteolipid protein (PLP) ratio in a mouse model with unperturbed structural and functional integrity of the myelin sheath and axons in the central nervous system.
Glia 35, 63-71 (2001)

Uschkureit, T., Sporkel, O., Stracke, J., Bussow, H., Stoffel, W.
Early onset of axonal degeneration in double (plp-/-mag-/-) and hypomyelinosis in triple (plp-/-mbp-/-mag-/-) mutant mice.
J. Neurosci. 20, 5225-5233 (2000)

Vahlensieck, M., Brüser, P., Schmidt, H.M., Schild, H.H.
Nutritialgefäßkanäle. Magnetresonanztomographische Differentialdiagnose karpaler zystischer Läsionen?
Radiologe 40, 469-472 (2000)

Vahlensieck, M., Linneborn, G., Schild, H.H., Schmidt, H.M.
[Magnetic resonance imaging (MRI) of the bursa around the knee joint].
Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr. 173, 195-9 (2001)

Vahlensieck, M., Schmidt, H.M.
Normales Knochenmark und seine Variationen in der MRT.
Radiologe 40, 688-693 (2000)

Viebahn, C.
The anterior margin of the mammalian gastrula: comparative and phylogenetic aspects of its role in axis formation and head induction.
Curr. Top. Dev. Biol. 46, 63-103 (1999)

Viebahn, C.
Hensen's node.
Genesis 29 , 96-103 (2001)

Wanner, I., Baader, S.L., Oberdick, J., Schilling, K.
Changing subcellular distribution and activity-dependent utilization of a dendritically localized mRNA in developing Purkinje cells.
Molec. Cell. Neurosci. 15, 275-287 (2000)

Wartenberg, H., Ihmer, A., Schwarz, S., Miething, A., Viebahn, C.
Mitotic arrest of female germ cells during prenatal oogenesis. A colcemid-like, non-apoptotic cell death.
Anat. Embryol. (Berl) 204 , 421-435 (2001)

Wulfhekel, U.
Die Struktur der Leber und der Gallenwege
in: Spezielle Pathologische Anatomie (Bd. 10) Doerr, Seifert, Uehlinger (Hrsg.): Pathologie der Leber und Gallenwege, Springer, Berlin, 1-51

Wulfhekel, U., Dullmann, J.
Storage of iron in bone marrow plasma cells. Ultrastructural characterization, mobilization, and diagnostic significance.
Acta Haematol. 101:7-15 (1999)

Zhang, X., Baader, S.L., Bian, F., Muller, W., Oberdick, J.
High level Purkinje cell specific expression of green fluorescent protein in transgenic mice.
Histochem Cell Biol 115, 455-464 (2001)


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