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FORSCHUNGSBERICHT 1999-2001

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Institut für Medizinische Biometrie, Informatik u. Epidemiologie

Allgemeine Angaben:
Sigmund-Freud-Str. 25, 53105 Bonn
Telefon: 0228 / 287-5400
Fax: 0228 / 287 -5032

Hauptamtliche Professoren:
Prof. Dr. Max P. Baur
Prof. Dr. Andreas J. W. Goldschmidt
Prof. Dr. Thomas F. Wienker

Wissenschaftliches Personal:
Universitätsstellen
Prof. Dr. rer. nat. Max Peter Baur
Dr. med. Oliver Boy
Dr. rer. nat. Rolf Fimmers
Prof. Dr. med. Andreas J. W. Goldschmidt
PD. Dr. rer. nat. Michael Knapp
Dr. med. Wolfgang Nagel
Dipl.-Stat. Claudia Nicolay
Dr. med. Gustav Quade
Dr. med. Joachim Richter
Susanne A. Seuchter-Prokosch
Dipl.-Phys. Konstantin Strauch
Prof. Dr. med. Thomas F. Wienker

Drittmittelstellen
Dr. rer. nat. Tim Becker (DFG)
Dipl.-Math. Manuela Bogdanow (DFG)
Dr. rer. nat. Johannes Dietter (DFG)
Dr. med. Christine Freitag (DFG)
Dr. med. Astrid Golla (DFG)
Med.-Dok. Tobias Höller (DFG)
Dr. rer. nat. Stefan Horvath (BONFOR)
Katharina Littmeyer (NRW)
Dr. med. Gabriele Schmidt-Wolf (NRW)
Dr. med. Michael Steffens (SFB 400)
Dr. sc. agr. Christine Windemuth (DFG)

Stipendiaten
Dr. Ruzong Fan (Humboldt-Stiftung)
Dr. rer. nat. Andreas Hahn (Grad.-Koll.)
Reedik Mägi (BONFOR)
Dipl.-Math. Anja Wille (Grad.-Koll.)

Forschungsschwerpunkte:
Biometrie: Statistische Methoden der Abstammungsbegutachtung
(Baur)

Biometrie: Statistische Methoden der Spurenuntersuchung
(Fimmers)

Biometrie: Kontrollierte Klinische Studien
(Fimmers, Baur)

Medizinische Informatik: Telemedizin
(Goldschmidt)

Genetische Epidemiologie: Methoden der Assoziationsanalyse
(Knapp, Horvath, Wienker)

Medizinische Informatik: Medizinische Informationsdienste im WWW
(Quade)

Medizinische Informatik: Verteilte elektronische Krankenakte
(Quade, Burde)

Genetische Epidemiologie: Methoden der Kopplungsanalyse
(Strauch, Seuchter, Wienker)

Genetische Epidemiologie: Kartierung von genetisch komplexen Krankheiten
(Wienker, Baur)

Besondere Forschungsförderung:
Argonauta
(Quade, EU )

Cancernet
(Quade, Baur, NW)

DFG Forschergruppe 423 "Genetische Epidemiologie und Medizinische Genetik komplexer Krankheiten"
(Baur, Propping, DFG)

Genetische Faktoren psychiatrischer Erkrankungen. DFG Schwerpunktprogramm
(Wienker, Windemuth, DFG, SFB 400)

Genetisch Epidemiologische Methodenzentren des NGFN
(Wienker, Fimmers, Baur, BMBF)

Molekulare Grundlagen zentralnervöser Erkrankungen. Teilprojekt D4: Entwicklung, Evaluation und Anwendung von statistischen Methoden der Kopplungs- und Assoziationsanalyse bei komplexen psychiartrischen Krankheiten
(Knapp, Wienker, DFG, SFB 400)

Neuronetz NGFN
(Wienker, Baur, BMBF)

Pathogenese von Krankheiten des Nervensystems
(Baur, Wienker, DFG Graduiertenkolleg)

Veröffentlichungen:

Alcais A, Baur MP
Introduction: Linkage analyses in single (non-Hutterite) populations.
Genet Epidemiol 21, S166-67

Bagli M, Papassotiropoulos A, Knapp M, Jessen F, Rao ML, Maier W, Heun R
Association between an interleukin-6 promoter and 3' flanking region haplotype and reduced Alzheimer's disease risk in a German population.
Neurosci Lett 283, 109-12

Baur MP
Der Zufall in der Biologie: Humangenetik.
Nova Acta Leopoldina NF 79, 308, 91-102

Baur MP
Paternity testing.
Encyclopedia of Biostatistics, Vol. 4, John Wiley, Chichester, 3276-80

Baur MP, Majumder PP, Amos CI, Freingold JI, King TM, Morton NE, Province MA, Spence MA, Thomas DC
International Genetic Epidemiology Societe: Commentary on "Darkness in El Dorado" by Patrick Tierney.
Genet Epidemiol 21, 81-04

Bayoumi R, Saar K, Lee YA, Nürnberg G, Reis A, Nur-E-Kamal M, Al-Gazali LI
Localisation of a gene for an autosomal recessive syndrome of macrocephaly, multiple epiphyseal dysplasia, and distinctive facies to chromosome 15q26.
J Med Genet 38, 369-73

Betz RC, Benedikt GH, Schoser, Kasper D, Ricker K, Ramirez A, Stein V, Torbergsen T, Lee YA, Nöthen MM, Wienker TF, Malin JP, Propping P, Reis A, Mortier W, Jentsch FJ, Vorgerd M, Kubisch C
Mutations in CAV3 cause mechanical hyperirritability of skeletal muscle disease.
Nat Genet 28, 218-19

Betz RC, Lee Y-A, Bygum A, Brandrup F, Bernal AI, Toribio J, Ignacio A, Kukuk GM, Ibsen HHW, Rasmussen HB, Wienker TF, Reis A, Propping P, Kruse R, Cichon S, Nöthen MM
A gene for hypotrichosis simplex of the scalp maps to chromosome 6p21.3.
Am J Hum Genet 66, 1979-83

Bosse K, Betz CR, Lee YA, Wienker TF, Reis A, Kleen H, Propping P, Cichon S, Nöthen M
Localization of a gene for syndactyly type 1 to chromosome 2q34-q36.
Am J Hum Genet 66, 492-97

Caspari R, Uhlhaas S, Friedl W, Knapp M, Propping P
Mapping a gene for nonspecific X-linked mental retardation (MRX 75) to Xq24-q26.
Am J Med Genet 93, 290-93

Cichon S, Kruse R, Hillmer AM, Kukuk G, Anker M, Altland K, Knapp M, Propping P, Nöthen MM
A distinct gene close to the hairless locus on chromosome 8p underlies hereditary marie unna type hypotrichosis in a german family.
Brit J Dermatol 143, 811-14

Cichon S, Schmidt-Wolf G, Schumacher J, Müller DJ, Hürter M, Schulze TG, Albus M, Borrmann-Hassenbach M, Franzek E, Lanczik M, Fritze J, Kreiner R, Weigelt B, Minges J, Lichtermann D, Lerer B, Kanyas K, Strauch K, Windemuth C, Baur MP, Wienker TF, Maier W, Rietschel M, Propping P, Nöthen MM
A possible susceptibility locus for bipolar affective disorder in chromosomal region 10q25-q26.
Mol Psychiat 6, 3, 342-49

Cichon S, Schumacher J, Müller DJ, Hürter M, Windemuth C, Strauch K, Hemmer S, Schulze TG, Schmidt-Wolf G, Albus M, Borrmann-Hassenbach M, Franzek E, Lanczik M, Fritze J, Kreiner R, Reuner U, Weigelt B, Minges J, Lichtermann D, Lerer B, Kanyas K, Baur MP, Wienker TF, Maier W, Rietschel M, Propping P, Nöthen MM
A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q.
Hum Mol Genet 10, 25, 2933-44

Daser A, Koetz K, Batjer N, Jung M, Rüschendorf F, Goltz M, Ellerbrok H, Renz H, Walter J, Paulsen M
Genetics of atopy in a mouse model: polymorphism of the IL-5 receptor alpha chain.
Immunogenetics 51, 8-9, 632-38

Eichenbaum-Voline S, Baur MP, Knapp M
Role of the environmental risk factors in the genetic determinism of the Spilkilizing Myrmaedonia.
Genet Epidemiol 17, Suppl. 1, 545-50

Erdmann J, Riedel K, Rohde K, Folgmann I, Wienker T, Fleck E, Regitz-Zagrosek V
Characterization of polymorphisms in the promoter of the human angiotensin II subtype 1 (AT1) receptor gene.
Ann Hum Genet 63, 369-74

Franke P, Nöthen MM, Wang T, Knapp M, Lichtermann D, Neidt H, Sander T, Propping P, Maier W
DRD4 exon III VNTR polymorphism -- susceptibility factor for heroin dependence? Results of a case-control and a family-based association approach.
Mol Psychiat 5, 101-4

Franke P, Nöthen MM, Wang T, Neidt H, Knapp M, Lichtermann D, Weiffenbach O, Mayer P, Hollt V, Propping P, Maier W
Human delta-opioid receptor gene and susceptibility to heroin and alcohol depentdence.
Am J Med Genet 88: 462-64

Franke P, Schwab SG, Gänsicke M, Knapp M, Delmo C, Zill P, Trixler M, Lichtermann D, Hallmayer J, Wildenauer DB, Maier W
DAT1 gene polymorphism in alcoholism: A family-based association study.
Biol Psychiat 45: 652-54

Franke P, Wang T, Nöthen MM, Knapp M, Neidt H, Albrecht S, Jahnes E, Propping P, Maier W
Nonreplication of association between mu-opioid-receptor gene (OPRM1) A(118)G polymorphism and substance dependence.
Am J Med Genet 105, 114-19

Franke P, Wang T, Nöthen MM, Knapp M, Neith H, Lichtermann D, Meyer zur Capellen K, Sander T, Propping P, Maier W
Susceptibility for alcoholism: DRD4 exon III polymorphism: a case-control and a family-based association approach.
Addict Biol 5, 289-95

Fuchshuber A, Kroiss S, Karle S, Berthold S, Huck K, Burton C, Rahman N, Koptides M, Deltas C, Otto E, Rüschendorf F, Feest T, Hildebrandt F
Refinement of the gene locus for autosomal dominant medullary cystic kidney disease type 1 (MCKD1) and construction of a physical and partial transcriptional map of the region.
Genomics 15; 72, 3, 278-84

Goldschmidt AJW
10 Thesen und Antithesen zum DRG-System.
Krankenhaus Umschau, Nov: 858-64

Goldschmidt AJW
Die dgitale Revolution in der Medizin.
Marburger Bund 52, 10, 6

Goldschmidt AJW
EDV-gestützte Informationssysteme für das Medical Controlling.
In: Goergen H, Ridel RR (Hrsg.): Medical Controlling. Dt.Ärzteverlag

Goldschmidt AJW
Medizin-Controlling. Aufgaben und Stellenwert im Unternehmen Krankenhaus.
Forum Med Inform 5, 9-13

Goldschmidt AJW
Pflichtenhefte - Einführung und Überblick.
In: Ohmann C, Prokosch HU, Stausberg J, Goldschmidt AJW, Sippel H (Hrsg.): Herusforderung in der Informationsverarbeitung an den Universitätskliniken des Landes Nordrhein-Westfalen. 3.-6. Workshop. Shaker, Aachen, 1999: 147-55

Goldschmidt AJW
Medical information processing - The motor of evidence-based-medicine.
ersch. in: Hasman A, Blobel B, Dudeck J, u.a.: Medical Infobahn for Europe. IOS Press, Amsterdam,

Goldschmidt AJW
General requirement ofr internet-based clinical trials.
ersch. in: Hasman A, Blobel B, Dudeck J, u.a.: Medical Infobahn for Europe. IOS Press, Amsterdam,

Goldschmidt AJW, Haas P
Hospital Information Systems (HIS) at the start of the millenium.
ersch. in: Hasman A, Blobel B, Dudeck J, u.a.: Medical Infobahn for Europe. IOS Press, Amsterdam,

Goldschmidt AJW, Ohmann C
Unterstützung de Datensammlung für klinische Studien durch Remote-Data-Entry.
MDI 3, 4-7

Goldschmidt AJW, Quade G
Was bringt die Informationsgesellschaft für Arzt und Patient?
ersch. in: Henke K, u.a.: Innovatives Gesundheitsmanagement im Zeichen Europas. Vereinte Krankenversicherung AG, Okt 2000, ISBN 3-932317-06-8, S. 45-54

Goldschmidt AJW, Rebholz F
Führungsinformationssysteme für leitende Ärzte im Krankenhaus.
Ersch. in: Hellmann, W.: Der Arzt mit Managementkompetenz, Kohlhammer Verlag, 1999, S. 122-32

Goldschmidt AJW, Weißbach L
Therapieforschung im Spannungsfeld zwischen Signifikanz und klinischer Relevanz.
Onkologe 11, 1008-14

Grohmann K, Schuelke M, Diers A, Hoffman K, Lucke B, Adams C, Bertini E, Leonhardt H, Muntoni F, Ouvrier R, Pfeufer A, Rossi R, Van Maldergem L, Wilmshurst JM, Wienker TF, Sendtner M, Rudnik-Schöneborn S, Zerres K, Hübner C
Mutations in the gene encoding immunoglobulin µ-binding protein 2 cause spinal muscular atrophy with respiratory distress type 1.
Nat Genet 29, 1, 75-77

Grohmann K, Wienker TF, Saar K, Rudnik-Schöneborn S, Stoltenburg-Didinger G, Rossi R, Novelli G, Nürnberg G, Pfeufer A, Wirth B, Reis A, Zerres K, Hübner C
Diapragmatic spinal muscular atrophy with respiratory distress is heterogeneous, and one form is linked to chromosome 11q13-q21.
Am J Hum Genet 65: 1459-62

Grünhage F, Schulze TG, Müller DJ, Lanczik M, Franzek E, Albus M, Borrmann-Hassenbach M, Knapp M, Cichon S, Maier W, Rietschel M, Propping P, Nöthen MM
Systematic screening for DNA sequence variation in the coding region of the human dopamine transporter gene (DAT1).
Mol Psychiat 5, 275-82

Hampe J, Wienker T, Nürnberg P, Schreiber S
Mapping genes for polygenic disorders: considerations for study design in the complex trait of inflammatory bowel disease.
Hum Hered 50, 91-01

Heils A, Haug K, Kunz WS, Fernandez G, Horvath S, Rebstock J, Propping P, Elger CE
Interleukin-1 beta gene polymorphism and susceptibility to temporal lobe epilepsy with hippocampa sclerosis.
Ann Neurol 48, 6, 948-49

Held T, Weber T, Krauss H, Ahle G, Hager B, Alfter D, Schulze T, Knapp M, Maier W, Rietschel M
Clinicial characteristics of patients with tardive dyskinesia.
Fortschr Neurol Psyc 68, 321-31

Henke L, Fimmers R, Josephi E, Cleef S, Dülmer M, Henke J
Usefulness of conventional blood groups, DANN-minisatellites, and short tandem repeat polymorphisms in paternity testing: a comparison.
Forensic Sci Int 103, 133-42

Henke L, Fimmers R, Reinhold J, Dülmer M, Cleef S, Arnold J, Henke J
Sequence analysis and population data on the "new" short tandem repeat locus D5S2360.
Forensic Sci Int 166, 55-8

Heun R, Kockler M, Papassotiropoulos A, Ptok U, Fimmers R
Subject and informant characteristics influence the reliability and validity of family history informations: an analysis based on the generalized estimating equations appoach.
Int J Meth Psychiat Res 9, 2, 60-67

Horvath S, Baur MP
Future directions of research in statistical genetics.
In: Medical Informatics, Biostatistics and Epidemiology for Efficient Health Care and Medical Research, Beiträge von der 44. Jahrestagung der GMDS, Heidelberg, September 1999, Medizin & Wissen, 50-53

Horvath S, Baur MP
Future directions of research in statistical genetics.
Stat Med 19, 24, 3337-43

Horvath S, Laird NM, Knapp M
The transmission/disequilibrium test and parental-genotype reconstruction for x-chromosomal markers.
Am J Hum Genet 66, 1161-67

Horvath S, Wei E, Xu X, Palmer LJ, Baur, M
Family-based association test method: Age of onset traits and covariates.
Genet Epidemiol 21, S403-08

Horvath S, Windemuth C, Knapp M
The disequilibrium maximum-liklehood-binomial test does not replace the transmission/disquilibrium test.
Am J Hum Genet 67, 6, 531-33

Horvath S, Xu X, Laird NM
The family based association test method: strategies for studying general genotype - phenotype associations.
Eur J Hum Genet 9, 301-6

Hranilovic D, Schwab SG, Jernej B, Knapp M, Lerer B, Albus M, Rietschel M, Kanyas K, Borrmann M, Lichtermann D, Maier W, Wildenauer D
Serotonin transporter gene and schizophrenia: evidence for association/linkage disequilibrium in families with affected siblings.
Mol Psychiat 5, 91-5

Imhoff M, Webb A, Goldschmidt A
Health informatics
Intensiv Care Med 27, 179-86

Immervoll T, Loesgen S, Dutsch G, Gohlke H, Herbon N, Klugbauer S, Dempfle A, Bickeboller H, Becker-Follmann J, Rüschendorf F, Saar K, Reis A, Wichmann HE, Wjst M
Fine mapping and single nucleotide polymorphism association results of candidate genes for asthma and related phenotypes.
Hum Mutat 18, 4, 327-36

Jacob N, Ruschendorf F, Schmidt-Egenolf M, Hennies HC, Friedl G, Ständer M, Wienker TF, Reis A, Traupe H
Promoter polymorphism at -238 of the tumor necrosis factor alpha gene is not associated with early onset psoriasis when tested by the transmission disequilibrium test (TDT).
J Invest Dermatol 112, 4, 514-15

Jung B
Praxis der Informationsverarbeitung in Krankenhaus und Versorgungsnetzen.
mdi 2, 61-2

Jung B, Goldschmidt AJW, Langenberg S
Practical aspects to realize data transfer between a patient administration mastersystem and clinical subsystems using ProtoGen/HLA7.
ersch. in: Hasman A, Blobel B, Dudeck J, u.a.: Medical Infobahn for Europe. IOS Press, Amsterdam, 499-03

Jung M, Poepping I, Perrot A, Ellmer AE, Wienker TF, Dietz R, Reis A, Osterziel KJ
Investigation of a family with autosomal dominant dilated cardiomyopathy defines a novel locus on chormosome 2q14-q22.
Am J Hum Genet 65, 1068-77

Klüken H, Voiß P, Gallenkemper G, Höller T, Rabe E
Akzeptanz verschiedener Therapieformen in der Phlebologie.
Phlebologie 28, 169-74

Knapp M
A note on power approximations for the transmission/desequilibrium test.
Am J Hum Genet 64, 1177-85

Knapp M
The transmission/disquilibrium test and parental-genotype reconstruction: the reconstruction-combined transmission/disquilibrium test.
Am J Hum Genet 64: 861-70

Knapp M
Using exact P values to compare the power between the reconstruction-combined transmission/disequilibrium test and the sib transmission/disequilibrium test.
Am J Hum Genet 65, 1208-10

Knapp M
Assoziationsstudien bei genetisch komplexen Erkrankungen.
Medizin Genet 4, 403-06

Knapp M
Re: "Biased tests of association: comparisons of allele frequencies when departing from Hardy-Weinberg proportions".
Am J Epidemiol 154, 287

Knapp M
Reconstructing parental genotypes when testing for linkage in the presence of association.
Theoret Popul Biol 60,3, 141-48

Körner I, Fischer B, Beetz R, Buiting K, Wingen A-M, Rübben H, Wienker TF, Horsthemke B, Gillessen-Kaesbach G
Rapid detection of an angiotensin type 2 receptor gene variant: no evidence for linkage and association with primary vesicoureteral reflux.
Gene Function & Disease 1, 5-6, 1-6

Kramer MH, Quade G, Hartemann P, Exner M
Waterborne diseases in Europe - 1986-96.
J Am Water Works Ass Jan, 48-53

Kraus JA, Wenghöfer M, Glesmann N, Mohr S, Beck M, Schmidt MC, Schröder R, Berweiler U, Roggendorf W, Diete S, Dietzmann K, Heuser K, Müller B, Fimmers R, von Deimling A, Schlegel U
TP53 gene mutations, nuclear p53 accumulation, expression of Waf/p21, Bcl-2, and CD95 (APO-1/Fas) proteins are not prognostic factors in de novo glioblastoma multiforme.
J Neurooncol 52,3, 263-72

Kroiss S, Huck K, Berthold S, Rüschendorf F, Scolari F, Caridi G, Ghiggeri GM, Hildebrandt F, Fuchshuber A
Evidence of further genetic heterogenety in autosomal dominant medullary cystic kidney disease.
Nephrol Dial Transpl 15, 6, 818-21

Kupka MS, Ellinger T, Goldschmidt AJW, van der Ven H
Effizienzsteigerung einer ambulanten universitären Einrichtung durch Process Designer und Workflow Management Systeme.
Inform Biometrie Epidemiol 32, 2-3, 209-10

Kupka MS, Ellinger T, van der Veen H, Baur MP, Goldschmidt AJW
IT-unterstütztes Geschäftsprozeßmanagement am Beispiel einer Reproduktionsmedizinischen Universitätsklinik.
ersch. in: Hasman A, Blobel B, Dudeck J, u.a.: Medical Infobahn for Europe. IOS Press, Amsterdam, 523-27

Kupka MS, Nagel WJ, van der Ven H, Baur MP, Goldschmidt AJW
Die Integration von Pflichtenheften als Instrument des Qualitätsmanagements am Beispiel der Reproduktionsmedizin in Deutschland.
In: Medical Informatics, Biostatistics and Epidemiology for Efficient Health Care and Medical Research, Beiträge von der 44. Jahrestagung der GMDS, Heidelberg, September 1999, Medizin & Wissen, 136-38

Kupka MS, Richter O, van der Ven H, Goldschmidt AJW
Web-basierte Portale in der Frauenheilkunde.
mdi 3, 76-82

Kupka MS, Tutschek B, Richter O, Goldschmidt AJW
Klinische Informationsverarbeitung in der gynäkologischen Onkologie.
Gynäkologe 33, 164-71

Kurz T, Strauch K, Heinzmann A, Braun S, Jung M, Rüschendorf F, Moffatt MF, Cookson WO, Inacio F, Ruffilli A, Norsdov-Hansen G, Peltre G, Förster J, Kuehr J, Reis A, Wienker TF, Deichmann KA
A European study on the genetics of mite sensitization.
J Allergy Clin Immun 106, 5, 1, 925-32

Laird NM, Horvath S, Xu X
Implementing a unified approach to familiy-based tests of association.
Genet Epidemiol 19, S36-S42

Lee Y-A, Rüschendorf F, Windemuth C, Schmitt-Egenolf M, Stadelmann A, Nürnberg G, Ständer M, Wienker TF, Reis A, Traupe H
Genomewide scan in german families reveals evidence for a novel psoriasis-susceptibility locus on chromosome 19p13.
Am J Hum Genet 67, 4, 1020-24

Lee Y-A, Wahn U, Kehrt R, Tarani L, Businco L, Gustafsson D, Andersson F, Ornaje AP, Wolkertstorfer A, vBerg A, Hoffmann U, Küster W, Wienker TF, Rüschendorf F, Reis A
A major susceptibility locus for atopic dermatitits maps to chromosome 3q21.
Nat Genet 26, 4, 470-73

Lichtermann D, Hranilovic D, Trixler M, Franke P, Jernej B, Delmo CD, Knapp M, Schwab SG, Maier W, Wildenauer DB
Support for allelic association of a polymorphic site in the promoter region of the serotonin transporter gene with risk for alcohol dependence.
Am J Psychiat 157, 2045-47

Lottermoser K, Petras S, Pöge U, Fimmers R, Hertfelder H-J, Schiermeyer B, Vetter H, Düsing R
The fibrinolytic system in chronic renal failure.
Eur J Med Res 6, 372-76

Melchior D, Hammer P, Fimmers R, Schuller H, Albers P
Long term results and morbidity of paraaortic compared with paraaortic and iliac adjuvant radiation in clinical stage I seminoma.
Anticancer Res21, 4B, 2989-93

Momhinweg E, Luckenbach C, Fimmers R, Ritter H
D3S1358: Sequence analysis and gene frequency in a German population.
For Sci Int 95,2, 173-78

Müller B, Schmidt MC, Schmidt O, Hayashi Y, Rollbrocker B, Waha A, Fimmers R, Volk B, Warnke P, Ostertag CB, Wiestler OD, von Deimling A
Molecular genetic analysis as a tool for evaluating stereotactic biopsies of glioma specimens.
J Neuropath Exp Neur 58, 1: 40-45

Müller DJ, Schulze TG, Knapp M, Held T, Krauss H, Weber T, Ahle G, Maroldt A, Alfer D, Maier W, Nöthen MM, Rietschel M
Familial occurrence of tardive dyskinesia.
Acta Psychiat Scan 104, 375-379.

Niemann S, Becker-Follmann J, Nürnberg G, Rüschendorf F, Sieweke N, Hügens-Penzel M, Traupe H, Wienker TF, Reis A, Müller U
Assignment of PGL3 to chromosome 1 (q21-q23) in a family with autosomal dominant non-chromaffin paraganglioma.
Am J Med Genet 98, 32-36

Nöthen MM, Cichon S, Rohleder H, Hemmer S, Franzek E, Fritze J, Albus M, Borrmann-Hassenbach M, Kreiner R, Weigelt B, Minges J, Lichtermann D, Maier W, Craddock N, Fimmers R, Höller T, Baur MP, Rietschel M, Propping P
Evaluation of linkage of bipolar affective disorder to chromosome 18 in a sample of 57 German families.
Mol Psychat 4, 1, 76-84

Oehring RD, Miletic M, Valter MM, Pietsch T, Neumann J, Fimmers R, Schlege U
Vascular endothelial growth factor (VEGF)in astrocytic gliomas - a prognostic factor?
J Neuo-Oncol 45, 117-25

Ohmann C, Prokosch HU, Stausberg J, Goldschmidt AJW, Sippel H
Herusforderung in der Informationsverarbeitung an den Universitätskliniken des Landes Nordrhein-Westfalen.
3.-6. Workshop. Shaker-Verlag, Aachen, ISBN 3-8265-4554-0

Omran H, Fernandez C, Jung M, Häffner K, Fargier B, Villaquiran A, Waldherr R, Gretz N, Brandis M, Rüschendorf F, Reis A, Hildebrandt F
Identification of a new gene locus for adolescent nephronophthisis on chromosome 3q22 in a large venezuelen pedigree.
Am J Hum Genet 66, 118-27

Omran H, Haffner K, Volkel A, Kuehr J, Ketelsen UP, Ross UH, Konietzko N, Wienker TF, Brandis M, Hildebrandt F
Homozyygosity mapping of a gene locus for primary ciliary dyskinesia on chomosome 5p and identification of the heavy dynein chain DNAH5 as a candidate gene.
Am J Resp Cell Mol Biol 23, 5, 696-02

Palmer LJ, Jacobis KB, Scurrah KJ, Xin Xu, Horvath S, Weiss ST
Genome-wide linkage analysis in a general population sample using oA2 random effects (SSARs)fitted by Gibbs sampling.
Genet Epidemiol 21, Suppl I, S674-79

Pani MA, Knapp M, Donner H, Braun J, Baur MP, Usadel KH, Badenhoop K
Vitamin D receptor allele combinations influence genetic susceptibility to type 1 diabetes in germans.
Diabetes 49, Mar, 504-07

Perabo F, Sharma S, Gierer R, Wirger A, Fimmers R, Steiner G, Adam M, Schultze-Seemann W
Circulating intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and e-selectin in urological malignancies.
Indian J Cancer 38, 1-7

Pfeiffer KA, Fimmers R, Engels G, van der Ven G, van der Ven K
The HLA-G genotype ist potentially associated with idiopathic recurrent spontaneous abortion.
Mol Hum Reprod 7, 4, 373-78

Propping P, Friedl W, Wienker TF, Uhlhaas S, Zerres K
ADULT syndrome allelic to limb mammary syndrome?
Am J Med Genet 90, 2, 179-82

Quade G, Burde B, Zenker S, Goldschmidt A
CancerNet online - ein Beitrag zur Verbesserung der onkologischen Versorgung.
Z Gyn 122, 646-50

Quade G, Burde B, Zenker S, Goldschmidt A, Baur MP
Deutsche Ausgabe der Patienteninformationen aus dem NCI. CancerNet.
Ersch. in: Euler B. u.a. (Hrsg.) Multimedia in der Medizin. Proc des Aachener Workshops, 27-28.10.1999, Wissenschaftsverlag, Aachen

Quade G, Burde B, Zenker S, Nagel W, Goldschmidt A
Recherchefunktionalität / -algorithmen von Suchsystemen im Internet.
In: Medical Informatics, Biostatistics and Epidemiology for Efficient Health Care and Medical Research, Beiträge von der 44. Jahrestagung der GMDS, Heidelberg, September 1999, Medizin & Wissen, 329-32

Quade G, Goldschmidt AJW
Kommunikationstechnologien im Überblick - Aktueller Stand.
ersch. in.: Hellmann: Management von Gesundheitsnetzen, Kohlhammer, Stuttgart

Quade G, Nagel W, Burde B, Goldschmidt AJW
CancerNet - Fünf Jahre Leitlinien im Internet.
Perspectives on Managed Care 2, 2, 43-44

Quade G, Novotny J, Burde B, May F, Beck LEJ, Goldschmidt AJW
Worldwide telemedicine services based on distributed multimedia electronic patient records by using the second generation Web Server hyperwave.
JAMIA SympSuppl: 916-20

Quade G, Zenker S, Burde B, Goldschmidt A
Differneces in demographic data regarding physicians and patients in the US or abroad using a medically oriented internet information service.
ersch. in: Hasman A, Blobel B, Dudeck J, u.a.: Medical Infobahn for Europe. IOS Press, Amsterdam, 668-72

Rietschel M, Krauss H, Müller DJ, Schulze TG, Knapp M, Marwinski K, Maroldt AO, Paus S, Grünhage F, Propping P, Maier W, Held T, Nöthen MM
Dopamine D3 receptor variant and tardive dyskinesia.
Eur Arch Psy Clin N 250, 31-5

Rietschel M, Schorr A, Albus M, Franzek E, Kreiner R, Held T, Knapp M, Müller DJ, Schulze TG, Propping P, Maier W, Nöthen MM
Association study of the tryptophan hydroxylase gene and bipolar affective disorder using family-based internal controls
Am J Med Genet 96, 310-11

Rolf B, Keil W, Brinkmann B, Roewer L, Fimmers R
Paternity testing using Y-STR haplotypes: assigning a probability for paternity in cases of mutations.
Int J Legal Med 115, 12-15

Rubie C, Schmidt F, Knapp M, Sprandel J, Wiegand C, Meyer J, Jungkunz G, Riederer P, Stöber G
The human dopamine transporter gene: the 5'-flanking region reveals five diallelic polymorphic sites in a Caucasian population sample.
Neurosci Lett 297, 125-128

Sander T, Schulz H, Saar K, Gennaro E, Riggio MC, Bianchi A, Zara F, Luna D, Bulteau C, Kaminska A, Ville D, Cieuta C, Picard F, Prud'homme JF, Bate L, Sundquist A, Gardiner RM, Jannssen GAMAJ, deHaan GJ, Kastelijn-Nolst-Trinite DGA, Bader A, Lindhout D, Riess O, Wienker TF, Janz D, Reis A
Genome search for susceptibility loci of common idiopathic generalized epilepsies.
Hum Mol Genet 9, 10, 1465-72

Sander T, Schulz H, Vieira-Saeker AM, Bianchi A, Sailer U, Bauer G, Scaramelli A, Wienker TF, Saar K, Reis A, Janz D, Epplen JT, Riess O
The confirmatioon analysis of a putative major susceptibility locus for juvenile myoclonic epilepsy on chromosome 15q14.
Am J Med Genet 88, 2: 182-87

Schappert B, Köhler M, Wolf K, Fimmers R, Stechert R
Umstellungen von einem FCKW-haltigen Beta2-Sympathomimetikum auf eine FCKW-freie Darreichungsform.
Der Kassenarzt, Dt. Ärztemagazin Sonderdruck 33/34, 31-37

Schild RL, Indefrei D, Eschweiler S, van der Ven H, Fimmers R, Hansmann M
Three-dimensional endometrial volume calculation and pregnancy rate in an in-vitro fertilization programme.
Hum Reprod 14, 5: 1255-58

Schild RL, Fimmers R, Hansmann M
Kann die 3D-Volumetrie von fetalem Oberarm und Oberschenkel konventionelle 2D-Gewichtsschätzungen verbessern?
Ultaschall in Med 30: 31-37

Schild RL, Fimmers R, Hansmann M
Fetal weight estimation by three-dimensional ultrasound.
Ultrasound Obstet Gynecol 16, 445-52

Schild RL, Holthaus S, d'Alquen J, Fimmers R, Dorn C, vander Ven H, Hansmann M
Quantitative assessment of subendometrial blood flow by three-dimensional-ultrasound is an important predictive factor of implantation in an in-vitro fertilization programme.
Hum Reprod 15, 1 89-94

Schild RL, Knobloch C, Dorn C, Fimmers R, VanderVen H, Hansmann M
Endometrial receptivity in an in vitro fertilization program as assessed by spiral artery blood flow, endometrial thickness, endometrial volume, and uterine artery blood flow.
Fertil Steril 75, 2, 361-66

Schild RL, Wallny T, Fimmers R, Hansmann M
Fetal lumbar spine volumetry by three-dimensional ultrasound.
Ultrasound Ostet Gynecol 13: 335-39

Schild RL, Wallny T, Fimmers R, Hansmann M
The size of the fetal thoracolumbar spine: a three-dimensional ultrasound study.
Ultrasound Obstet Gynecol 16, 468-72

Schlegel U, Pels H, Glasmacher A, Kleinschmidt R, Schmidt-Wolf I, Helmstaedter C, Fließbach K, Deckert M, van Roost D, Fimmers R, Bode U, Klockgether T
Combined systemic and intraventricular chemotherapy in primary CNS lymphoma: a pilot study.
J Neurol Neurosur Ps 71, 1, 118-22

Schmitt-Egenolf M, Windemuth C, Hennies HC, Albis-Camps M, von Engelhardt B, Wienker TF, Reis A, Traupe H, Blasczyk R
Comparative association analysis reveals that corneodesmosin is more closely associated with psoriasis than HLA-Cw*602-B*5701 in German families.
Tissue Antigens 57, 5, 440-46

Schulze-Röbbecke R, Hartemann P, Fimmers R, Hagenau C
Comparison of membrane filtration methods for the recovery of legionellae from naturally contaminated doestic drinking water supplies.
Zbl Hyg Umweltmed 202: 51-59

Schulze TG, Müller DJ, Krauss H, Gross M, Bauer I, Fangerau-Lefevre H, Illes F, Ohlraun S, Fimmers R, Cichon S, Held T, Propping P, Nöthen MM, Maier W, Rietschel M
Brief research communication - caught in the trio trap? Potential selection bias inherent to association studies using parent-offspring trios.
Am J Med Genet 105, 4, 351-53

Schulze TG, Müller DJ, Krauss H, Marwinski K, Maroldt AO, Fernandez ANY, Fimmers R, Held T, Maier W, Nöthen MM, Rietschel M
Affective symtomatology in schizophrenia: a risk factor for tardive dyskinesia?
Eur Psychiat 16, 1, 71-4

Schulze TG, Müller DJ, Krauss H, Scherk H, Ohlraun S, Syagailo YV, Windemuth C, Neidt H, Grässle M, Papassotiropoulos A, Heun R, Nöthen MM, Maier W, Lesch K-P, Rietschel M
Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder.
Am J Med Genet 96, 6, 801-03

Schumacher J, Schulze TG, Wienker TF, Rietschel M, Nöthen MM
Pharmacogenetics of clozapine response.
The Lancet 356, 9228, 506-07

Sekundo W, Böker T, Fimmers R
Induced corneal astigmatism using an asymmetric corneoscleral tunnel and a large-optic intraocular lens.
J Cataract Refract Surg 26, 79-82

Seuchter SA, Hebebrand J, Klug B, Knapp M, Lehmkuhl G, Poustka F, Schmidt M, Remschmidt H, Baur MP
Complex segregation analysis of families ascertained through Gilles de la Tourette Syndrome.
Genet Epidemiol 18, 33-47

Shelley JH, Baur MP
Paul Martini: The first clinical pharmacologist?
The Lancet 353: 1870-73

Stinner B, Goldschmidt AJW, Celik I, Rothmund M
Wissenschaftliches erkennen, richtig lesen und verstehen.
Dtsch Med Wschr 124, 773-9

Stöber G, Meyer I, Wienker TF, Saar K, Knapp M, Jatzke S, Schmid M, Lesch KP, Beckamnn H
hKCNN3 which maps to chromosome lq21 is not the caustive gene in periodic catatonia, a familial subtype of schizophrenia.
Eur Arch Psy Clin N 250, 4, 163-68

Stöber G, Meyer I, Wienker TF, Saar K, Knapp M, Jatzke S, Schmid M, Lesch KP, Beckamnn H
Linkage and family-based association study of schizophrenia and the synampsin III locus that maps to chromosome 22 q13.
Am J Med Genet (Psychiat. Genet) 96, 3, 392-97

Stöber G, Phuhlmann B, Nürnberg G, Schmidtke A, Reis A, Franzek E, Wienker TF
Towards the genetic bassis of periodic catatonia pedigree sample for genome scan I and II.
Eur Arch Psy Clin N 251, Suppl 1, 25-30

Stöber G, Saar K, Rüschendorf F, Meyer J, Nürnberg G, Jatzke S, Franzek E, Reis A, Lesch KP, Wienker TF, Beckmann H
Splitting schizophrenia: periodic catatonia-susceptibility locus on chromosome 15q15.
Am J Hum Genet 67, 5, 1201-07

Stöber G, Syagailo YV, Okladnova O, Jungkunz G, Knapp M, Beckmann H, Lesch KP
Functional PAX-6 gene-linked polymorphic region: Potential association with paranoid schizophrenia.
Biol Psychiat 45, 1585-91

Strauch K
Kopplungsanalyse bei genetisch komplexen Erkrankung mit genomischem Imprinting und Zwei-Genort-Krankheitsmodellen.
Medizinische Informatik, Biometrie und Epidemiologie 87, Urban & Vogel, ISBN 3-860094-174-7

Strauch K, Bogdanow M, Fimmers R, Baur MP, Wienker TF
Linkage analysis of asthma and atopy including models with genomic imprinting.
Genet Epidemiol 21(Suppl 1), S 204-09

Strauch K, Fimmers R, Baur MP, Wienker TF
Parametric linkage analysis with automatic maximization of the LOD score over disease model parameters.
Genet Epidemiol 21, 176-77

Strauch K, Fimmers R, Kurz T, Deichmann KA, Wienker TF, Baur MP
Parametric and nonparametric multipoint linkage analysis with imprinting and two-locus-trait models: application to mite sensitization.
Am J Hum Genet 66, 1945-57

Strauch K, Fimmers R, Wienker TF, Baur MP
Parametric and nonparametric multipoint linkage analysis for complex traits.
In: Medical Informatics, Biostatistics and Epidemiology for Efficient Health Care and Medical Research, Beiträge von der 44. Jahrestagung der GMDS, Heidelberg, September 1999, Medizin & Wissen, 58-60

Strauch K, Fimmers R, Wienker TF, Baur MP, Cichon S, Propping P, Nöthen MM
Strauch et al reply. Analysis of parental-origin effects in linkage data.
Mol Psychiat 126-27

Strauch K, Fimmers R, Windemuth C, Hahn A, Wienker TF, Baur MP
Linkage analysis with adequate modeling of a parent-of-origin effect.
Genet Epidemiol 17, Suppl. 1: S 331-36

Syagailo YV, Stöber G, Grassle M, Reimer E, Knapp M, Jungkunz G, Okladnova O, Meyer J, Lesch KP
Association analysis of the functional monoamine oxidase A gene promoter polymorphism in psychiatric disorders.
Am J Med Genet 105, 168-71

van der Ven K, Fimmers R, Engels G, van der Ven H, Krebs D
Evidence for major histocompatibility complex-mediated effects on spermatogenesis in humans.
Hum Reprod 15, 1, 189-96

Vanita, Singh JR, Sarhadi VK, Singh D, Reis A, Rüschendorf F, Becker-Follmann J, Jung M, Sperling K
A Novel Form of "Central Pouchlike" Cataract, with Sutural Opacities, Maps to Chromosome 15q21-22.
Am J Hum Genet 68, 2, 509-14

VanRoost D, Hartmann A, Quade G
Changes of cerebral blood flow following dexamethasone treatment in brain tumour patients. A Xe/CT study.
Acta Neurochir (Wien) 143, 37-44

Vogt IR, Shimron-Abarbanell D, Neidt H, Erdmann J, Cichon S, Schulze TG, Müller DJ, Maier W, Albus M, Borrmann-Hassenbach M, Knapp M, Rietschel M, Propping P, Nöthen MM
Investigation of the human serotonin 6 (5-HT6) receptor gene in bipolar affective disorder and schizophrenia.
Am J Med Genet 96, 217-21

Von Bokhofen H, Jung M, Smits APT, van Beersum S, Ruschendorf F, van Steensel M, Veenstra M, Tuerlings JHAM, Mariman ECM, Brunner HG, Wienker TF, Reis A, Ropers HH, Hamel BCJ
Limb mammary syndrome (LMS): A new genetic disorder with mammary hypoplasia, ectrodactyly and other hand/foot anomalies maps to human chromosome 3q27.
Am J Hum Genet 64, 2, 538-46

vonDeimling A, Fimmers R, Schmidt MC, Bender B, Fassbener F, Nagel J, Jahnke R, Kaskel P, Duerr EM, Doopmann J, Maintz D, Steinbeck S, Wick W, Platten M, Muller DJ, Przkora R, Waha A, Blumcke B, Wellenreuther R, Meyer-Puttlitz B, Schmidt O, Mollenhauer J, Poustka A, Stangl AP, Lenartz D, vonAmmon K
Comprehensive allelotype and genetic analysis of 466 human nervous system tumors.
J Neuropath Exp Neur 59, 6, 544-58

Wallny TA, Schild RL, Fimmers R, Wagner UA, Hansmann ME, Schmitt O
The fetal spinal canal. A three-dimensianal study.
Ultrasound Med Biol 25, 9, 1329-33

Wang T, Franke P, Neidt H, Cichon S, Knapp M, Lichtermann D, Maier W, Propping P, Nöthen MM
Association study of the low-activity allele of catechol-O-methyltransferase and alcoholism using a family-based approach.
Mol Psychiat 6, 109-11

Wille A, Leal SM
Novel selection criteria for genome scans of complex traits.
Genet Epidemiol 21, S800-4

Willinek WA, Ludwig M, Lennarz M, Höller T, Stumpe KO
High-normal serum homocysteine concentrations are associated with an increased risk of early atherosclerotic carotid artery wall lesions in healthe subjects.
J Hypertens 18, 425-30

Windemuth C, Hahn A, Strauch K, Baur MP, Wienker TF
Linkage analysis in alcohol dependence.
Genet Epidemiol 17, Suppl. 1: 403-07

Wirth B, Herz M, Wetter A, Hahnen E, Moskau S, Rudnik-Schöneborn S, Wienker TF, Zerres K
Quantitative analysis of survival motor neuron copies: Identification of subtle SMNI mutations in patients with spinal muscular atrophy, genotype-phenotype correlation, and implications for genetic counseling.
Am J Hum Genet 65, 5, 1340-56

Wittekindt O, Schwab SG, Burgert E, Knapp M, Albus M, Lerer B, Hallmayer J, Rietschel M, Segman R, Borrmann M, Lichtermann D, Crocq MA, Maier W, Morris-Rosendahl DJ, Wildenauer DB
Association between hSKCa3 and schizophrenia not confirmed by transmission disequilibrium test in 193 offspring/parents trios.
Mol Psychiat 4, 267-70

Xin Xu, Palmer LJ, Horvath S, Wei LJ
Combining multiple phenotypic traits optimally for detecting linkage with sib-pair observations.
Genet Epidemiol 21, Suppl I, S479-83

Zipp F, Windemuth C, Dichgans J, Wienker TF, Martin R, Muller C
Peripheral blood cell bulk cultures are not suited for the analysis of the genetic control of T-cell cytokine function.
Immunol Lett 78, 1, 21-27

Zipp F, Windemuth C, Pankow H, Dichgans J, Wienker TF, Martin R, Müller C
Multiple sclerosis associated amino acids of polymorphic regions relevant for the HLA antigen binding are confined to HLA-DR2.
Hum Immuno 61, 10, 1021-30


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