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FORSCHUNGSBERICHT 1999-2001

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Zentrum für Pathologie Pathologisches Institut

Allgemeine Angaben:
Sigmund-Freud-Str. 25, 53127 Bonn
Telefon: (0228)/287-5375
Fax: (0228)/287-5030
eMail: Beate.Roick@ukb.uni-bonn.de

Hauptamtliche Professoren:
Prof. Dr. med. Reinhard Büttner Institutsdirektor ab 01.08.2001
Prof. Dr. med. Hans-Peter Fischer
Prof. Dr. med. Ulrich Pfeifer Institutsdirektor bis 31.07.2001
Prof. Dr. med. Nicolas Wernert

Wissenschaftliches Personal:
Universitätsstellen
Dr. med. P. Behrens
PD Dr. med. F. Dombrowski
Dr. med. T. Evert
Dr. med. N. Friedrichs
Dr. med. Susanne Haas
Dr. rer. nat. A. Hügel
Dr. rer. nat. R. Jäger
Prof. Dr. med. Gisela Knöpfle
Dr. med. Micaela Mathiak
Dr. rer. nat. Sabine Merkelbach-Bruse
Dr. rer. nat. M. Rothe
Dr. med. U. Schildhaus
PD. Dr. rer. nat. H. Schorle
Dr. med. I. Theuerkauf
Dr. med. K. Tschubel
Dr. med. Barbara von Netzer
Dr. med. Eva Wardelmann
PD Dr. med. A. Wellmann
PD Dr. med. H. Zhou

Drittmittelstellen
Bipl. biol. Ralf Bauerndistel (Boehringer (Roche))
Judith Dahmen (DFG)
Dipl. biol. Julia Ehlermann (BONFOR)
Christiane Esch (Deutsche Krebshilfe)
Lucia Gullotti (DFG)
Dr. rer. nat. Jutta Kirfel (DFG)
Inge Losen (Wilhelm-Sander-Stiftung)
Dipl. biol. Sonja Matthiesen (DFG)
Jochen Maurer (BONFOR)
Ellen Paggen (Boehringer (Roche))
Barbara Reddemann (Deutsche Krebshilfe)
Anke Röper (DFG)
Dipl. biol. Anja Septinus (Wilhelm-Sander-Stiftung)
Susanne Weber (BONFOR)

Stipendiaten
Dr. med. Ali Okuducu (WHO)

Forschungsschwerpunkte:
Angiogenese, Tumor-Stroma-Interaktionen
(Binnenbruck, Sahin, Dreschers, Hahne, Okuducu, Florin)

Arbeitsgruppe "Molekularbiologische Diagnostik", Metastasierung maligner Tumoren
(Dahmen, Losen, Merkelbach, Paggen)

Hepatokarzinogenese im Tiermodell
(Dombrowski, Evert, Pfeifer)

Lebertumoren
(Fischer, Theuerkauf)

Stoffwechselerkrankungen der Leber
(Fischer, Zhou, Esch Reddemann)

Molekulargenetische Analysen urogenitaler Tumoren
(Hong Lu, Zhan Lu Ma)

Funktionen von AP-2 Transkriptionsfaktoren in Zelldifferenzierung und Tumorgenese
(Kirfel, Matthiesen, Septinus)

Familiäre Tumorerkrankungen (HNPCC, Muir-Torre-Syndrom)
(Mathiak, Merkelbach-Bruse, Esch, Losen)

Tissue-Microarray-Analysen an Normal- und Tumorgewebe
(Wardelmann, Heim, Steiner)

Gastrointestinale Stromatumoren
(Wardelmann, Merkelbach-Bruse, Losen, Heim, Esch)

Besondere Forschungsförderung:
Analyse der anaplastischen Lymphomkinase (p80) auf Genaktivierung
(Jeske, Wellmann, BONFOR)

Analyse der Genexpression während der Lymphangiogenese im transgenen Mausmodell RipVEGF-C x Rip1 Tag2
(Okuducu, BONFOR)

cerbB2-Expression nicht kleinzelliger Bronchialkarzinome
(Fischer, Esch, Steiner, Hoffmann-La-Roche)

Die Bedeutung des Ets1 Transkriptionsfaktors in der Angiogenes und Antiangiogenese
(Dreschers, Hahne, Deutsche Krebshilfe, Deutsche Forschungsgemeinschaft, BONFOR)

Funktion des Gens der autosomal rezessiven polyzystischen Nierenerkrankung
(Röper, Gullotti, Deutsche Forschungsgemeinschaft)

Funktionen des AP-2rep Gens in der Nierenentwicklung
(Septinus, Losen, Wilhelm-Sander-Stiftung)

Genica-Brustkrebs-Studie
(Haas, Burmeister-Falderbaum, Esch, BMBF)

HER2-Status in Brustkrebsgewebe
(Theuerkauf, Esch, Steiner, Hoffmann-La-Roche)

MIA Promoter
(Bauerndistel, Paggen, Boehringer (Roche))

Mikrodissektionsbasierte Analyse der Genexpression in der Prostata und dem Prostatakarzinom
(Hong Lu, Zhan Lu Ma, Deutsche Forschungsgemeinschaft, BONFOR)

Polaritätsabhängige Sekretion stromarelevanter (c-ets1-induzierender) Faktoren aus epithelialen Tumorzellen
(Wardelmann, Wernert, Pfeifer, BONFOR)

Regulation von AP-2
(Kirfel, Matthiesen, Dahmen, Deutsche Forschungsgemeinschaft)

Verbundprojekt "Familiärer Darmkrebs"
(Mathiak, Esch, Reddemann, Florin, Deutsche Krebshilfe e.V., BONFOR)

Veröffentlichungen:

Albers P, Ko Y, Wardelmann E, Schmidt D, Adam M, Vetter H, Müller SC
Limitations of detection of bone-marrow micrometastasis in prostate carcinoma patients by CK18/PSA immunocytochemistry and PSA RT-PCR.
Anticancer Res 20, 2107-2112

Alberty J, Wardelmann E
Histomorphologic reaction patterns in cervical lymph nodes of different neck sites.
Lymphology 34, 77-83

B"ni R, Wellmann A, Chen G, Hofbauer G, Brinkmann U
Apoptosis-Associated CAS Protein in Benign and Malignant Cutaneous Melanocytic Lesions
Am J Dermpath. 2, 125-128

Bachmann R, Dombrowski F, Block W, Oeksendal A, Schild H
Enhanced tumor detection in the presence of liver cirrhosis: Experimental study about the diagnostic value of a superparamagnetic iron oide MR imaging contrast agent (NSR 0430)
J. Magn. Reson. Imag. 9, 251-256

Behrens P, Brinkmann U, Fogt F, Wernert N, Wellmann A
Implication of the proliferation and apoptosis associated CSE1L/CAS gene for breast cancer development
Anticancer Res 21 (2001), 2413-7

Behrens P, Jeske W, Wernert N, Wellmann A
Downregulation of Clusterin expression in testicular germ cell tumours
Pathobiol 69 (2001), 19-23

Behrens P, Rothe M, Florin A, Wellmann A, Wernert N
Invasive properties of serous human epithelial ovarian tumors are related to Ets-1, MMP-1 and MMP-9 expression
Int J Mol Med 8 (2001), 149-54

Behrens P, Rothe M, Wellmann A, Krischler J, Wernert N
The Ets-1 transcription factor is up-regulated together with MMP 1 and MMP 9 in the stroma of pre-invasive breast cancer
J Pathol 194 (2001), 43-50

Blümcke I, Gienecke K, Wardelmann E, Beyenburg S, Kral T, Sarioglu N, Pietsch T, Wolf HK, Schramm J, Elger CE, Wiestler OD
The CD34 epitope is expressed in neoplastic and malformative lesions associated with chronic, focal epilepsies.
Acta Neuropathol 97, 481-490

Böhm I, Schupp G, Pakos E, Bauer R
Niedrig dosiertes Methotrexat beim Prä-Sézary-Syndrom.
Internist 40, 974-977

Bosserhoff AK, Dreau D, Hein R, Landthaler M, Holder WD, Buettner R
MIA, a serological marker of malignant melanoma
Recent Res Cancer Res 158, 158-168

Bosserhoff AK, Echtenacher B, Hein R, Buettner R
Functional role of MIA in regulating metastasis of malignant melanoma cells in an in vivo model
Melanoma Res. 11, 417-421

Brauers A, Buettner R, Jakse G
Second resection and prognosis of primary high risk superficial bladder cancer
J. Urol. 165, 808-810

Brinkmann U, Brinkmann E, Bera TK, Wellmann A, Pastan I
Tissue-specific alternative splicing of the CSE1L/CAS (cellular apoptosis susceptibility) gene.
Genomics 15, 41-49

Diedrich O, Kraft CN, Sommer T, Zhou H, Perlick L
Die sekund"re Osteoathropathia hypertrophicans. Differentialdiagnose der posttraumatischen Verkn"cherung der Membrana interossea cruris.
Unfallchirugie 103, 597-601

Diedrich O, Kraft CN, Zhou H, Sommer T, Perlick L, Schmitt O
Orthop"dische Aspekte der kn"chernen Echinokokkose-Radiologische Diagnostik, aktuelle operative und medikament"se Therapieans"tze.
Z Orthop 139, 261-266

Dombrowski F, Klotz L, Hacker HJ, Li Y, Klingmueller D, Brix K, Herzog V, Bannasch P
Hyperproliferative Hepatocellular Alterations after Intraportal Transplantation of Thyroid Follicles
Am. J. Pathol. 156, 99-113

Dombrowski F, Kubitz R, Chittattu A, Wettstein M, Saha N, Haeussinger D
Electron-microscopic demonstration of multidrug resistance protein 2 (MrP2) retrieval from the canalicular membrane in response to hyperosmolarity and lipopolysaccharide
Biochem J. 348, 183-188

Evert M, Lehringer-Polzin M, Moebius W, Pfeifer U
Angiotropic large-cell lymphoma presenting as pulmonary small vessel occlusive disease
Hum. Path. 31, 879-882

Fischer HP, Ortiz-Pallardo( ME, Ko Y, Zhou H
Chronic liver disease in heterozygous alpha-1-antitrypsin deficiency PiZ.
J Hepatol (2000)33: 883-892

Fischer HP, Zhou H
Pathologie der Papilla vateri
Doerr W, Seifert G, Spezielle pathologische Anatomie, Bd 10, 2.Aufl.Pathologie der Leber und Gallenwege. Springer,Berlin, Heidelberg,New York,p 1219-1257

Fogt F, Wellmann A, Urbanski SJ, Noffsinger A, Poremba C, Zimmermann RL, Alsaigh N
Glut 1 expression in dysplastic and regenerative lesion of the colon
Int J Mol Med, 7, 615-9

Forkert R, Ko Y, Fronhoffs S, Tschubel K, Vetter H
Chronisch progrediente Polyglobulie und Thrombozytose
Schweiz. Rundsch. Med. Prax. 90, 741-746

Funke B, Epstein J A, Kochilas L K, Lu M M, Pandita R , Liao J, Bauerndistel R, Schuler T, Schorle H, Brown M C
Mice overexpressing genes from the 22q11 region deleted in velo-cardio-facial syndrome/DiGeorge syndrome have middle and inner ear defects
Hum Mol Genet 10, 2549-2556

G"nther K, Merkelbach-Bruse S, Amo-Takyi B, Handt S, Schr"der W, Tietze L
Differences in genetic alterations between primary lobular and ductal breast cancers detected by comparative genomic hybridization.
J Pathol 193, 40-47

Gabriel HD, Strobl B, Hellmann P, Buettner R, Winterhager E
Organization and regulation of the rat Cx31 gene: implication for a cruacial role of the intron region
Eur. J. Biochem. 268, 1749-59

Gerhards F, Buettner R, Jaenicke S
Aberrant salivary gland tissue as a differential diagnosis of branchiogenic cysts: A case report
HNO 49, 476-78

Glasmacher A, Hahn C, Leutner CC, Molitor E, Wardelmann E, Losem C, Sauerbruch T, Marklein G, Schmidt-Wolf IGH
Breakthrough invasive fungal infections in neutropenic patients after prophylaxis with itraconazole.
Mycoses 42, 443-451

Guenther K, Fleischer A, Buettner R, Bosserhoff AK
Detection of invasion-related chromosomal changes in highly and weakly invasive melanoma cell clone by a modified CGH approach
Melanoma Res. 11, 105-115

Guetgemann A, Golob M, Mueller S, Buettner R, Bosserhoff AK
Isolation of invasion-associated cDNAs in melanoma
Arch. Dermatol. Res. 293, 283-290

Haeusinger D, Schließ F, Dombrowski F, vom Dahl S
Involvement of p38MAPK in the regulation of proteolysis by liver cell hydratation
Gastroenterology 116, 921-935

Hellerbrand C, Bosserhoff AK, Seegers S, Lingner G, Wrede C, Lock G, Schoelmerich J, Buettner R
Mutation analysis of the HFE gene in German Hemochromatosis patients and controls using automated SSCP-based capillary electrophoresis and a new PCR-ELISA technique
Scand. J. Hepatlogy 36, 1211-16

Hermanns B, Brunn A, Seipelt I, Sachweh JS, Schoendube FA, Schwarz ER, Buettner R
Fulminant toxoplasmosis in a heart-transplant recipient
Path. Res. Pract. 197, 211-15

Hilger-Eversheim K, Moser M, Schorle H, Buettner R
Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control
gene 260, 1-12

Hirohashi S, Ishak KG, Kojiro M, Wanless IR, Theise ND, Tsukuma H, Blum HE, Deugner, Puig P, Fischer HP, Sakamoto M
Hepacellular carcinoma.
Hamilton SR, Aaltonen LA (Eds.), World health Organization Classification of Tumors. Pathology and Genetics of Tumors of the Digestive Systems, IARC Press: Lyon

Holthaus S, Schlid RL, Schmolling J, Zhou H, Krebs D, Hansmann M
Ungew"hnlicher Befund eines Ovarialtumors.
Geburth Frauenheilk 59, 528-530

Horre( R, Feil E, Stangel AP, Zhou H, Gilges S, W"hrmann A, de Hoog GS, Meis JFGM, Merklein G, Schaal KP
Scedosporiose des Gehirns mit letalem Ausgang nach Fuáverletzung.
Mycoses 43, 33-36

Klotz L, Hacker HJ, Klingmueller D, Bannasch P, Pfeifer U, Dombrowski F
Hepatocellular Alterations after Intraportal Transplantation of Ovarian Tissue in Ovariectomized Rats
Am. J. Pathol. 156, 1613-1626

Koopmann J, Dombrowski F, Rockstroh JK, Pfeifer U, Sauerbruch T, Spengler U
Fatal Pneumonia in an AIDS Patient Coinfected with Adenovirus and Pneumocystis carinii
Infection 28, 323-325

Ko Y, Abel J, Hardt V, Br"de P, Antony C, Donal S, Fischer HP, Ortiz-Pallardo( ME , Thier R, Sachanidis A, Vetter H, Bolt HM, Herberhold C, Br"ing T
Association of CYP1B1 codon 432 mutant allele in head and neck squamous cell cancer is reflected by somatic mutations of p53 in tumor tissue.
Cancer Res (2000)61: 4398-4404

Kreft B, Dombrowski F, Block W, Bachmann R, Fackeldey A, Traeber F, Pfeifer U, Schild H
Evaluation of different models of experimental induced liver cirrhosis for MRI research with correlation to histopathological findings
Invest Radiol 34, 360-366

Kreft B, Flacke S, Conrad R, Pauleit D, Bachmann R, Wardelmann E, Albers P, Schild HH
Pathologisch/MR-tomographische Korrelation und Differentialdiagnose von malignen Nierentumoren.
Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 171, 106-112

Kruse R, Uhlhaas S, Lamberti C, Keller KM, Jackisch C, Steinhard J, Knoepfle G, Loff S, Back W, Stolte M, Jungck M, Propping P, Friedl W, Denne DE
Peutz-Jeghers Syndrome: Four novel inactivating germline mutations in the STK11 gene
Human Mutat in Brief #227

Kuhl CK, Klaschik S, Mielcarek P, Pakos E, Schmiedel A, Schild HH
Do T2-weighted pulse sequences help with the differential diagnosis of enhancing lesions in dynamic breast MRI?
J Magn Reson 9, 187-196

Kuhl CK, Mielcareck P, Klaschik S, Leutner CC, Wardelmann E, Gieseke J, Schild HH
Dynamic breast MR imaging: are signal intensity time course data useful for differential diagnosis of enhancing lesions?
Radiology 211, 101-110

Kuhl CK, Morakkabati N, Leutner CC, Schmiedel A, Wardelmann E, Schild HH
MR-imaging-guided large-core (14-gauge) needle biopsy of small lesions visible at breast MR imaging alone.
Radiology 220, 31-39

Kuhl CK, Schmutzler RK, Leutner CC, Kempe A, Wardelmann E, Hocke A, Maringa M, Pfeifer U, Krebs D, Schild HH
Breast MRI imaging screening in 192 women proved or suspected to be carriers of a breast cancer suspectibility gene: preliminary results.
Radiology 215, 267-279

Kunkel LM, Wernert N, Wirth B
Human and mouse rad17 genes: identification, localization, genomic structure and histological expression pattern in normal testis and seminoma
Hum. Genet. 105, 17-27

L"ring C, Perlick L, Rhiem K, Zhou H, Diedrich O
Differentialdiagnose von lumbosakralen Schmerzen in der Gravidit"t-Kasuistik der Erstmanifestation eines Plattenepithelkarzinoms
Z Orthop 139, 308-310

Lamberti C, Kruse R, Ruelfs C, Caspari R, Wang Y, Jungck M, Mathiak M, Malayeri HR, Friedl W, Sauerbruch T, Propping P
Microsatellite instability-a useful diagnostic tool to select patients at high risk for hereditary non-polyposis colorectal cancer: a study in different groups of patients with colorectal cancer
GUT 44, 839-43

Lauschke H, Caspari R, Friedl W, Schwarz B, Mathiak M, Propping P, Hirner A
Detection of APC and k-ras mutations in the serum of patients with colorectal cancer
Cancer Detect Prev 25 (1), 55-61

Lehnerdt KH, Broicher R, Tschubel K, Walther E
Der interessante Fall Nr. 49
Laryngo-Rhino-Otol. 80, 687-689

Leutner CC, Gieseke J, Lutterbey G, Kuhl CK, Flacke S, Glasmacher A, Theisen A, Wardelmann E, Grohe C, Schild HH
MRT versus CT in der Diagnostik von Pneumonien: Evaluation einer T2-gewichteten ultraschnellen Turbo-Spin-Echo-Sequenz (UTSE).
Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 170, 449-456

Leutner CC, Gieseke J, Lutterbey G, Kuhl CK, Glasmacher A, Wardelmann E, Theisen A, Schild HH
MR imaging of pneumonia in immunocompromised patients: comparison with helical CT.
Am J Roentgenol 175, 391-397

Look MP, Gerard A, Rao GS, Sudhop T, Fischer HP, Sauerbruch T, Spengler U
InterferonIantixidant combination therapy for chronisch hepatitis c - a controlled pilot trial.
Antiviral Res (1999)43: 113-122

Maldonado-Saldivia J, Funke B, Schuler T, Morrow B E, Schorle H
Expression of Cdcrel-1 (Pnutl1), a gene frequently deleted in velo-cardio-facial syndrome/DiGeorge syndrome
Mech Dev 96, 121-124

Mathiak G, Wening JV, Mathiak M, Neville LF, Jungbluth K
Serum cholesterol is elevated in patients with Achilles tendon ruptures
Arch Orthop Trauma Surg 119(5-6), 280-4

Merkelbach-Bruse S, K"se S, Losen I, Bosserhoff AK, B"ttner R
High throughput genetic screening for the detection of hereditary non-polyposis colon cancer (HNPCC) using capillary electrophoresis.
Comb Chem High Throughput Screening 3, 455-460

Merscher S, Funke B, Epstein J A, Heyer J, Puech A, Lu M M, Xavier R J, Demay B, Russell R G, Factor S, Tokooya K, St-Jore B, Lopez M, Pandita R, Lia M, Carrion D, Xu K, Schorle H, Kobler J, Scambler P, Wynshaw_Boris A, Skoultchi A, Morrow B, and Kucherlapati R
TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome.
Cell 104, 619-629

Minor T, Akbar S, Tolba R, Dombrowski F
Cold preservation of fatty liver grafts: prevention of functional and ultrastructural impairments by venous oxygen persufflation
J. Hepatol. 32, 105-111

Mumme T, Buettner R, Peiper C, Schumpelick V
Pancreatoblastoma: a rare malignant neoplasm in early adulthood
Chirurg 72, 806-11

Neuhaus T, Seewald S, Zhou H, Frechen A, Layer G, Vetter H
Cushing-Syndrom bei ektoper ACTH-Produktion unklarer Lokalisation
Schweiz Rundsch Med Prax, 88, 679-685

Neulen J, Wenzel D, Hornig C, Wuensch E, Weissenborn U, Grundwald R, Buettner R, Weich H
Poor responder-high responder: the importance of soluble vascular endothelial growth factor receptor 1 in ovarian stimulation protocols
Hum. Reprod. 16, 621-626

Oehmichen M, Schulz-Schaeffer W, Kretzschmar H, Theuerkauf I, Gerling I, Meissner C
Creutzfeldt-Jacob disease in a case of suspected chronic heavy metal poisoning.
J Forensic Sci 46 (2001), 702-707

Oehmichen M, Theuerkauf I, Meissner C
Is traumatic axonal injury (AI) associated with an early microglial activation? Application of a double-labeling technique for simultaneous detection of microglia and AI.
Acta Neuropathol 97 (1999), 491-494

Ortiz-Pallardo( ME , Ko Y, Sachinidis A, Vetter H, Fischer HP, Zhou H
Detection of alpha-1-antitrypsin PiZ individuals by SSCP and DANN sequencing in formalin-fixed and paraffin-embedded tissue. A comparation with immunohistochemical analysis.
J Hepatol.32, 406-411

Ortiz-Pallardo( ME, Zhou H, Fischer HP, Neuhaus T, Sachinidis A, Vetter H, Br"ning T, Ko Y
Rapid analysis of alpha-1-antitrypsin PiZ Genotype by a light-cycler-assisted PCR approach.
J Molecul Med (2000)

Ortlepp JR, Hoffmann R, Killian A, Lauscher J, Merkelbach-Bruse S, Hanrath P
The 4G/5G promotor polymorphism of the plasminogen activator inhibitor 1 gene and late lumen loss after coronary stent placemant in smoking and nonsmoking patients.
Clin Cardiol 24, 585-591

Ortlepp JR, Janssens U, Bleckmann F, Lauscher J, Merkelbach-Bruse S, Hnarath P, Hoffmann R
A chymase gene variant is assaciated with atherosclerosis in venous coronary artery bypass grafts.
Coron Artery Dis 12, 493-497

Pels H, Deckert-Schl"ter M, Glasmacher A, Kleinschmidt R, Oehring R, Fischer HP, Bode U, Schlegel U
Primary central nervous system lymphoma: a clinicopathological study of 28 cases.
Hematol Oncol (2000)18: 21-32

Perlick L, B"this H, Zhou H, Diedrich O
Das Non-Hodgkin-Lymphom als Differtialdiagnose der Spondylodiszitis.
Unfallchirugie 103, 409-412

Perlick L, Sommer T, Zhou H, Diedrich O
Atypische Prothesenlockerung am H"ftgelenk.
Radiologe 40, 577-579

Perlick L, Zander D, Wallny T, Zhou H
Das desmoplastische Fibrom der Fibula: die schwierige klinische, radiologische und histologische Diagnose.
Zbl Chir. 125, 895-899

Pfeifer U
Spezielle Pathologische Anatomie
Bd. 10, Pathologie der Leber und der Gallenwege (G. Seifert Hrsg.), Springer Verlag, Berlin, Heidelberg, New York, 743-803

Plum A, Hallas G, Magin T, Dombrowski F, Hagendorff A, Schumacher B, Volpert C, Kim JS, Lamers WH, Evert M, Meda P, Traub P, willecke K
Unique and shared functions of different connexins in mice
Curr. Biol. 10, 1083-1091

Pohl C, Harbrecht U, Greinacher A, Theuerkauf I, Biniek R, Hanfland P, Klockether T
Neurologic complications in immune-mediated heparin-induced thrombocytopenia.
Neurology 54 (2000), 1240-1245

Poser I, Dominguez AG de Herreros, Varnai A, Buettner R, Bosserhoff AK
Loss of E-Cadherin expression in melanoma cells involves upregulation of the transcriptional repressor Snail
J. Biol. Chem- 276, 24551-6

Radke PW, Merkelbach-Bruse S, Messmer BJ, vom Dahl J, Doerge H, Naami A, Vogel G, Handt S, Hanrath P
Infectious agents in coronary lesions obtained by endatherectomy: prevalence, distribution pattern, co-infection, and clinical findings.
Coron Artery Dis 12, 1-6

Radke PW, Merkelbach-Bruse S, Naami A, Vogel G, Handt S, Vom Dahl J, Messmer BJ, Hanrath P
Cytomegalievirus in koronaren Atheromen bei Patienten mit schwerer koronarer Herzerkrankung.
Med. Klinik 96, 129-134

Radke PW, Ortlepp JR, Merkelbach-Bruse S, Messmer BJ, Kaiser A, Kronenberger S, Handt S, Hanrath P
Prevalence of cytomegalovirus in nonrheumatic stenotic aortic valves.
Am J Cardiol 89) 477-479

Rhode HT, Riesener KP, Buettner R, Schumpelick V
Leiomyosarcoma of the splenic artery
Chirurg 72, 844-6

Richter O, Wardelmann E, Dombrowski F, Schneider C, Kiel R, Wilhelm K, Schmolling J, Kupka M, van der Ven H, Krebs D
Extracorporal perfusion of the human uterus as an experimental model in gynaecology and reproductive medicine.
Hum Reprod 15, 1235-1240

Rose M, Brock D, Knoepfle G, Zielen S
Kongenitale zystisch-adenomatoide Malformation - Klinisches Spektrum und Management
Pneumonologie 55, 79-83

Rothe M, Albers P, Wernert N
Loss of heterozygosity, differentiation, and clonality in microdissected male germ cell tumors
J. Pathol 188, 389-394

Rudlowski C, Rath W, Becker AJ, Wiestler OD, Buettner R
Trastuzumab and breast cancer (correspondence)
N. Engl. J. Med. 345, 997-8

Scharf JG, Ramadori G, Dombrowski F
Analysis of the IGF Axis in Preneoplastic Hepatic Foci and Hepatocellular Neoplasms Developing after Low-Number Pancreatic Islet Transplantation into the Livers of Streptozotocin Diabetic Rats
Lab. Invest. 80, 1399-1411

Schuierer M, Hilger-Eversheim K, Dobner T, Bosserhoff AK, Moser M, Turner J, Crossley M, Buettner R
Induction of AP-2alpha expression by adenoviral infection involves inactivation of the Krueppel-like zinc finger transcriptional repressor AP-2rep.
J. Biol. Chem. 276, 27944-49

Sommer T, Vahlhaus C, Hofer U, von Smekal A, Wardelmann E, Bierhoff E, Pauleit D, Wilhelm K, Textor T, Schild HH
MRT-Diagnostik kardialer Myxome: Sequenzevaluierung und Differentialdiagnose.
Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 170, 156-162

Steiner G, Heimbach D, Pakos E, Müller SC
Simultaneous contralateral metastasis from a renal clear cell carcinoma.
Scand J Urol Nephrol 33, 136-137

Stein M, Tschubel K
Der interessante Fall Nr. 29
Laryngo-Rhino-Otol. 78, 581-583

Stein M, Zhou H
Der interessante Fall 47.
Laryngo-Rhino-Otol. 80, 483-484

Stoll R, Renner C, Zweckstetter M, Brueggert M, Ambrosius D, Palme S, Golob M, Breibach I, Buettner R, Voelter W, Holak TA, Bosserhoff AK
The extracellular human melanoma inhibitory activity (MIA) protein adopts an SH3 domain-like fold
EMBO J. 20, 340-9

Strunk M, Fischer HP, Schild HH
Transjugular liver biopsy with a modified Tru-Cut system: a retrospective study of ist success and complications.
ROFO Fortschr Geb R"ntgenstr Neuen Bildgeb Verfahr (1999)170.394-396

Talbot D, Loring J, Schorle H
Spatiotemporal expression pattern of keratins in skin of AP-2alpha-deficient mice
J Invest Dermatol 113, 816-820

Tasci S, Sch"fer H, Zhou H, Ewig S, L"deritz B
Pseudomembranous Aspergillus fumigatus tracheobronchitis causing life-threatening tracheobronchial obstruction in a mechanically ventilated patient.
Int Care Med 26,143-144

Temme A, Ott T, Dombrowski F, Willecke K
The extent of synchronous initiation and termination of DANN synthesis in regenerating mouse liver is dependent on connexin32 expressing gap junctions
J. Hepatol. 32, 627635

Theuerkauf I, Evert M, Cochet Z, Pfeifer U
Perforation eines mukozelenartig transformierten Hartmann-Stumpfes.
Chirurg 71 (2000), 572-574

Theuerkauf I, Lickfett L, Harbrecht U, Pohl C, Fischer HP, Pfeifer U
Segmental hepatic vein thrombosis associated with heparin-induced thrombocytopenia.
Virchows Arch 436 (2000), 88-91

Theuerkauf I, Strunk H, Brensing KA, Schild HH, Pfeifer U
Infarction and laceration of liver parenchyma caused by wedged CO2 venography before TIPS insertion.
Cardiovasc Intervent Radiol 24 (2001), 64-67

Theuerkauf I, Zhou H, Fischer HP
Immunohistochemical patterns of human liver sinusoids under different conditions of pathologic perfusion.
Virchows Arch 438 (2001), 498-504

Thieblemont C, Pack S, Sakai A, Vortmeyer A, Wellmann A, Zhuang Z, Raffeld R
Allelic loss of 11q13 as detected by MEN1 -FISH is not associated with mutation of the MEN 1 gene in lymphoid neoplasms
Leukemia 13, 85-89

Tietze L, Borntr"ger J, Klosterhalfen B, Amo-Takyi B, Handt S, G"nther K, Merkelbach-Bruse S
Expression and Function of á1 and á3 Integrins of human mesothelial cells in vitro.
Exp Mol Pathol 66, 131-139

Tietze L, G"nther K, H"rbe A, Pawlik C, Klosterhalfen B, Handt S, Merkelbach-Bruse S
Benign metastasizing leiomyoma: a cytogenetically balanced but clonal disease.
Hum Pathol 31, 126-128

Valter MM, Huegel A, Su Huang HJ, Cavenee WK, Wiestler OD, Pietsch T, Wernert N
Expression of the Ets-1 transcription factor in human astrocytomas is associated with Fms-like tyrosine kinase-1 (Flt-1)/vascular endothelial growth factor receptor-1 synthesis and neoangiogenesis
Cancer Res. 59, 5608-5614

von Lilienfeld-Toal M, Ebert O, Kretzschmar H, Theuerkauf I, Glasmacher A, Schmidt-Wolf IG
Small bowel obstruction in acute myelogenous leukemia: stenosis or paralysis?
Ann Hematol 80 (2001), 611-613

Vorthmeyer A, Chan C, Chew EY, Matteson DM, Shen DF, Wellmann A, Weil R, Zhuang Z
Morphologic and Genetic Analysis of Retinal Angioma Associated with Massive Gliosis in a Patient with von Hippel-Lindau Disease
Gr"fes Archiv 237, 513-517

Wallny T, Theuerkauf I, Schild RL, Perlick L, Bertelbeck DS
The three-dimensional ultrasound evaluation of the rotator cuff-an experimental study.
Eur J Ultrasound 11 (2000), 135-141

Wallny T, Theuerkauf I, Schild RL, Perlick L, Schulze-Bertelsbeck D
Histomorphologie versus 3-dimensionaler Ultrasonographie der Rotatorenmanschette.
Z Orthop Ihre Grenzgeb 139 (2001), 75-79

Wardelmann E, Ling H, Heim I, Schlebusch H, Heidland A, Pfeifer U
Influence of NH4Cl on polarized release of endogenous protein degradation products and on morphology in LLC-PK1 cells.
Am J Nephrol 20, 74-81

Weiskirchen R, Moser M, Weiskirchen S, Erdel M, Dahmen S, Buettner R, Gressner AM
The Cysteine- and Glycine-richt Protein CRP2 is a Cytokine Sensitive LIM Domain protein with Restricted Expression in Liver and Affinity for the Protein Inhibitor of Activated Stat1 (PIAS1)
Biochem J. 359, 485-96

Wellmann A, Flemming P, Behrens P, Wuppermann K, Lang H, Oldhafer K, Pastan I, Brinkmann U
High Expression of the proliferation and apoptosis associated CSE1/CAS Gene in hepatitis and liver neoplasms correlated with tumor progression
Int J Mol Med 5, 489-494

Wellmann A, Thieblemont C, Pitiluga S, Sakai A, Siebert P, Jaffe ES, Raffeld M
Detection of differentially expressed genes in lymphomas using cDNA arrays: Identification of clusterin as a new diagnostic marker for Anaplastic Large Cell Lymphomas (ALCL)
Blood 96, 398-404

Wernert N, Löcherbach C, Behrens P, Wellmann A, Hügel A
Presence of genetic alterations in microdissected stroma of human colon and breast cancers
Anticancer Res 21, 2259-2264

Wernert N, Stanjek A, Kiriakidis S, Hügel A, Jha HC, Mazitschek R, Giannis A
Inhibition of in vivo angiogenesis by ets-1 antisense oligonucleotides - Inhibition of Ets-1 transcription factor expression by the antibiotic fumagillin.
Angew Chem Int Edit 38, 3228-3231

Wittekind C, Fischer HP, Ponchon T
Combinned hepatocellular and cholangiocarcinoma.
Hamilton SR, Aaltonen LA (Eds.), World health Organization Classification of Tumors. Pathology and Genetics of Tumors of the Digestive Systems, IARC Press: Lyon

Wittekind C, Fischer HP, Ponchon T
Bile duct cystadenoma and cystadenocarcinoma.
Hamilton SR, Aaltonen LA (Eds.), World health Organization Classification of Tumors. Pathology and Genetics of Tumors of the Digestive Systems, IARC Press: Lyon

Zhou H, Fischer HP
Leberver"nderungen bei heterozygotem Alpha-1-Antitrypsin-Mangel PiZ.
Pathologe 21, 433-440

Zhou H, Klein B, Heimbach D, Matz B, Klehr HU
Diagnose und erfolgreiche Kontrolle einer Polyomavirus-Infektion in der Transplantatniere- Ein Fallbericht.
Visceralchirugie 36,169-172

Zhou H, Ortiz-Pallardo( ME, Ko Y, Fischer HP
Is heterozygous alpha-1-antitrypsin deficiency PiZ a risk factor for primary liver carcinoma?
Cancer 88, 2668-2676

Zhou H, Wolff M, Pauleit D, Fischer HP, Pfeifer U
Multiple macroregenerative nodulus in liver cirrhosis due to Budd-Chiari syndrome.
Hepatogastroenterology 47, 522-527


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