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FORSCHUNGSBERICHT 1999-2001

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Zentrum für Pathologie Institut für Neuropathologie

Allgemeine Angaben:
Sigmund-Freud-Straße 25, 53127 Bonn
Telefon: 0228 / 287-6602 oder 6523
Fax: 0228 / 287-4331
eMail: neuropath@uni-bonn.de
WWW: http://www.meb.uni-bonn.de/neuropath/

Hauptamtliche Professoren:
Professor Dr. med. Torsten Pietsch
Prof. Dr. med. Guido Reifenberger Stiftungsprofessor der Deutschen Krebshilfe
Prof. Dr. med. Otmar D. Wiestler Institutsdirektor

Wissenschaftliches Personal:
Universitätsstellen
Priv.Doz. Dr. med. Ingmar Blümcke
Priv.Doz. Dr. med. Oliver Brüstle
Priv.-Doz. Dr. med. Martina Deckert-Schlüter
Dr. med. Volkmar Hans
Prof. Dr. med. Torsten Pietsch
Priv.-Doz. Dr. med. Herbert Radner
Dr. med. Dietmar R. Thal
Dr. rer. nat. Andreas Waha

Drittmittelstellen
Dr. med. Albert Becker (SFB/TR3)
Dipl. Biol. Hendrik Brune (BONFOR)
Dr. med. Karim Burkhardt (CHUV, Schweiz)
Dr. med. Rolf Buslei (SFB 400)
Dr. rer. nat. Tamara Glaser (Land NRW)
Priv.-Doz. Dr. med. Andrea Kindler-Roehrborn (BMBF)
Dr. med. Arend Koch (Deutsche Krebshilfe)
Dr. rer. nat. Bernd Kölsch (Dr. Mildred Scheel Stiftung für Krebsforschung)
Dipl. Biol. Manuel Montesinos-Rongen (Deutsche Krebshilfe)
Dipl. Biol. Iris Neidt (Deutsche Krebshilfe)
Dr. med. Alberto Perez (SFB 400)
Dr. rer. nat. Britta Rollbrocker (Deutsche Krebshilfe)
Dr. med. Björn Scheffler (Land NRW)
Dipl. Biol. Tanja Schmandt (BMBF)
Dr. rer. nat. Anke Waha (BMBF)
Dipl. Biol. Sascha Weggen (BONFOR)
Dr. rer. nat. Ruth Wellenreuther (DFG)
Dr. med. Marius Wernig (SFB 400)

Stipendiaten
Swantje Engelbrecht (Graduiertenkolleg)
Aksana Hrychyk (Graduiertenkolleg)
Manuel Löbach (Graduiertenkolleg)
Dr. Alberto Perez (Alexander von Humboldt Stiftung)
Jan Steffel (Graduiertenkolleg)

Forschungsschwerpunkte:
Neuropathologie und Pathogenese von Temporallappen-Epilepsien
(Blümcke, Becker, Wiestler)

Neurobiologische und molekulare Charakterisierung von Stammzellen des Zentralnervensystems
(Brüstle)

Molekulare Pathogenese primärer ZNS-Lymphome
(Deckert-Schlüter)

Neuroimmunologie und Pathogenese der murinen Toxoplasma-Encephalitis
(Deckert-Schlüter)

Neuroimmunologie traumatischer Hirnschäden.
(Hans)

Genetische Präposition für Carcinogen-induzierte neurale Tumoren
(Kindler-Röhrborn)

Molekulare Charakterisierung von Hepatoblastomen
(Pietsch)

Molekulare Charakterisierung von Medulloblastomen
(Pietsch, Wiestler)

Transgene Modelle für metabolische Myopathien
(Radner)

Molekulargenetische Charakterisierung von Tumoren der Mamma
(Schmutzler, Wiestler)

Hereditäres Mamma- und Ovarialcarcinom
(Schmutzler, Krebs, Propping, Wiestler, Nationales Verbundprojekt der Deutschen Krebshilfe)

Die Neuroanatomie der ß-Amyloid Ablagerungen beim Morbus Alzheimer
(Thal)

DNA-Methylierung in zentralnervösen Tumoren
(Waha, Wiestler)

Hirntumor-Referenzzentrum der Deutschen Gesellschaft für Neuropathologie und Neuroanatomie e.V.
(Wiestler)

Molekulare Diagnostik zentralnervöser Tumoren
(Wiestler)

Molekulare Charakterisierung von Gliomen
(Wiestler, Reifenberger)

Besondere Forschungsförderung:
A neuropathology platform for the classification of CNS alterations in mice from the ENU-mouse mutagenesis screen of the German Human Genome Project
(Wiestler, Zimmer, Hans & Falkai, Nationales Genomforschungsnetz des BMBF, Standort Bonn, Teilprojekt 15)

Bedeutung regulatorischer DNA Methylierung für die Pathogenese niedriggradiger neuroepithelialer Tumoren
(Waha, Wiestler, SFB400, Teilprojekt C7)

Brain Net: Nationale Gehirnbank des BMBF, Standort Bonn
(Wiestler, Thal, Falkai, BMBF)

C3-Stiftungsprofessur für molekulare Neuroonkologie
(Wiestler, Deutschen Krebshilfe)

Die Neuroanatomie der ß-Amyloid Ablagerungen beim Morbus Alzheimer
(Thal, DFG)

Entwicklungskontrollgene und embryonale Tumoren des Kindesalters
(Pietsch, Bennigsen- Förder-Preis des Landes Nordrhein-Westfalen 1998)

Epilepsie-assoziierte Veränderungen in der strukturellen und molekularen Organisation der Amygdala
(Yilmazer-Hanke, Blümcke, Schwegler, Schramm, SFB/TR3, Teilprojekt B2)

Familiärer Brust- und Eierstockkrebs
(Schmutzler, Propping, Schild, Wiestler, Nationales Verbundprojekt der Deutschen Krebshilfe)

Gene expression analysis in human and experimental focal epilepsies
(Wiestler, Blümcke, Becker, Nationales Genomforschungsnetz des BMBF, Standort Bonn, Teilprojekt 11)

Genetische Basis gynäkologischer Karzinome
(Schmutzler, Wiestler, Verbundprojekt des BMBF, Teilprojekt 1 und 6)

Genetische Prädisposition und Resistenz gegenüber der Entstehung chemisch induzierter Tumoren des Nervensystems
(Kindler-Röhrborn, Dr. Mildred Scheel Stiftung für Krebsforschung)

Immuntherapie maligner Hirntumoren - Etablierung eines Tumormodells in der Ratte und Evaluation einer Therapie mit bispezifischen Antikörpern in vitro und in vivo.
(Hans, BONFOR)

Mechnismen der Remyelinisierung durch ES-Zell abgeleitete gliale Vorläufer bei Entmarkungskrankheiten
(Brüstle, SFB400, Teilprojekt E4)

MedNet Pädiatrische Tumoren des BMBF
(Pietsch, BMBF, Teilprojekt zu Tumoren des Nervensystems)

Molekularbiologische Analyse Progressions-assoziierter genetischer Alterationen in Meningeomen
(Büschges, Boström, BONFOR)

Molekularbiologische Untersuchungen zur Pathogenese primärer Non-Hodgkin-Lymphome des Zentralnervensystems
(Deckert-Schlüter , Siebert, Schlegelberger, Wiestler, Dr. Mildred Scheel Stiftung für Krebsforschung)

Molekulare Charakterisierung von Gliomen
(von Deimling, Wiestler, Sonderforschungsbereich 400, Teilprojekt C1)

Molekulare Charakterisierung von Hepatoblastomen
(Pietsch, DFG)

Molekulare Diagnostik von Gliomen
(Wiestler, Reifenberger, von Deimling, Deutsche Krebshilfe)

Molekulare Neuropathologie der Temporallappen-Epilepsie
(Blümcke, Zimmer, Wiestler, SFB/TR3, Teilprojekt D1)

Molekulare Neuropathologie fokaler Epilepsien
(Blümcke, Wiestler, Sonderforschungsbereich 400, Teilprojekt B6)

Molekulare Pathogenese des Medulloblastoms
(Pietsch, Wiestler, Sonderforschungsbereich 400, Teilprojekt C2)

Myelin repair based on ES cell derived glial precursors
(Brüstle, Verbundprojekt der EU)

Neurale Stammzellen: Eine neue Perspektive für die Behandlung neurologischer Defizite
(Brüstle, Wiestler, Nachwuchsgruppenförderung aus dem Innovationsprogramm Forschung des Landes NRW)

Pathogenese von Krankheiten des Nervensystems
(Wiestler, DFG-Graduiertenkolleg an der Universität Bonn, Teilprojekt 5)

Quantitative RT-PCR Analyse von Neurotransmitter-Rezeptoren bei pharmako-resistenten Temporallappen-Epilepsien
(Becker, DFG-Forschungsstipendium)

Regulation und Funktion von Mikrogliazellen bei der murinen Toxoplasma-Encephalitis
(Deckert-Schlüter, Wiestler, DFG-Schwerpunktprogramm Mikroglia)

Stiftungslehrstuhl für Rekonstruktive Neurobiologie
(Wiestler, Brüstle, Gemeinnützige Hertie-Stiftung)

Transplantation ES-Zell abgeleiteter Vorläuferzellen bei Erkrankungen des zentralen Nervensystems
(Brüstle, Steinhäuser, Gieselmann, Scheffler, Wiestler, BMBF Förderschwerpunkt Biologischer Ersatz von Organfunktionen)

Transplantation neuraler Stammzellen in epileptogene Hippocampus-Segmente
(Brüstle, SFB/TR3, Teilprojekt D2)

Untersuchungen zur Bedeutung der Amplifikation und Überexpression zellulärer Onkogene in Glioblastomen
(Reifenberger, Sonderforschungsbereich 400, Teilprojekt C5)

Zellbiologische Charakterisierung und intracerebrale Transplantation in vitro generierter neuraler Vorläuferzellen
(Brüstle, BONFOR)

Zellersatz im Nervensystem
(Brüstle, Bennigsen Foerder Preis des Landes Nordrhein Westfalen 1999)

Zentrales Verwaltungsprojekt des Sonderforschungsbereichs 400
(Wiestler, DFG)

Zentrales Verwaltungsprojekt des transregionalen Sonderforschungsbereiches SFB/TR3
(Wiestler, DFG)

Veröffentlichungen:

An HX Beckmann MW Reifenberger G Bender HG Niederacher D
Gene amplification and overexpression of CDK4 in sporadic breast carcinomas is associated with high tumor cell proliferation.
Am J Pathol 154, 113-118 (1999)

Ardjomand N, Müllner K, El-Shabrawi Y, Berglöff J, Hofmann-Wellenhof R, Reich ME Radner H
Die korneale Langerhans Zelle und ihr Antigenmuster.
Spektrum der Augenheilkunde 13, 14-16 (1999)

Ardjomand N Schwarz T Berglöff J Radner H El-Shabrawi Y
Matrix Metalloproteinasen und deren Inhibitoren in normalen und Keratokonus Hornhäuten.
Spektrum der Augenheilkunde 14, 19-22 (2000)

Auer-Grumbach M Fazekas F Radner H Irmler A Strasser-Fuchs S
The Troyer syndrome: A combination of central brain abnormality and motor neuron disease?
J Neurol Neurosurg Psych 246, 556-61 (1999)

Babbe H, Roers A, Waisman A, Lassmann H, Goebels N, Hohlfeld R, Friese M, Schröder R, Deckert M, Schmidt S, Ravid R, Rajewsky K
Clonal expansions of CD8+ T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction.
J Exp Med 192, 393-404 (2000)

Bayer TA Thier M Roeb E Breuer B Weggen S Wiestler OD Weis J
Migratory potential of transplantable neural tumor cell lines.
Acta Neuropathol 97, 607-612 (1999)

Becker A.J, Löbach M, Klein H, Normann S, Nöthen M.M, von Deimling A, Mizuguchi M, Elger C.E, Schramm J, Wiestler O.D, Blümcke I
Mutational analysis of TSC1 and TSC2 genes in gangliogliomas.
Neuropathol. Appl. Neurobiol. 27: 105-114 (2001)

Becker AJ Gillardon F Blümcke I Langendörfer D Beck H Wiestler OD
Differential regulation of apoptosis-related genes in resistant and vulnerable subfields of the rat epileptic hippocampus.
Mol Brain Res, 67, 172-176 (1999)

Beyenburg S, Stoffel-Wagner B, Bauer J, Watzka M, Blümcke I, Bidlingmaier F, Elger C.E
Neuroactive steroids and seizure susceptibility.
Epilepsy Res. 44:141-153 (2001)

Beyenburg S, Stoffel-Wagner B, Watzka M, Blümcke I, Bauer J, Schramm J, Bidlingmaier F, Elger CE
Expression of cytochrome P450scc mRNA in the hippocampus of patients with temporal lobe epilepsy.
Neuroreport, 10, 3067-3070 (1999)

Beyenburg S, Watzka M, Blümcke I, Schramm J, Bidlingmaier F, Elger CE, Stoffel-Wagner B
Expression of mRNAs encoding for 17beta-hydroxisteroid dehydrogenase isozymes 1, 2, 3 and 4 in epileptic human hippocampus.
Epilepsy Res 41, 83-91 (2000)

Beyenburg S, Watzka M, Clusmann H, Blümcke I, Bidlingmaier F, Elger C.E, Stoffel-Wagner B
Messenger RNA of steroid 21-hydroxylase (CYP21) is expressed in the human hippocampus.
Neurosci. Lett. 308: 111-114 (2001)

Beyenburg S, Watzka M, Clusmann H, Blümcke I, Bidlingmaier F, Elger CE, Stoffel-Wagner B
Androgen receptor mRNA expression in the human hippocampus. Neurosci Lett 294, 25-28 (2000)

Bien CG, Schulze-Bonhage A, Deckert M, Urbach H, Helmstaedter C, Grunwald T, Schaller C, Elger C
Limbic encephalitis not associated with neoplasm as a cause of temporal lobe epilepsy.
Neurology 55, 1823-1828 (2000)

Blümcke, I Wiestler, O.D
Quality management in neuropathology. Acta Neurochirurg. 78: 73-77 (2001)

Blümcke I, Becker AJ, Klein C, Scheiwe C, Lie AA, Beck H, Waha A, Friedl MG, Kuhn R, Emson P, Elger C, Wiestler OD
Temporal lobe epilepsy associated up-regulation of metabotropic glutamate receptors: correlated changes in mGluR1 mRNA and protein expression in experimental animals and human patients.
J Neuropathol Exp Neurol 59, 1-10 (2000)

Blümcke I, Becker AJ, Normann S, Hans V, Riederer BM, Krajewski S, Wiestler OD, Reifenberger G
Distinct expression pattern of microtubule-associated protein-2 in human oligodendrogliomas and glial precursor cells.
J Neuropathol Exp Neurol 2001;60:984-93

Blümcke I, Becker A, Normann S, Hans V, Riederer B.M, Krajewski S, Wiestler O.D, Reifenberger G
Distinct expression pattern of microtubule-associated protein-2 in human oligodendrogliomas and glial precursor cells.
J. Neuropathol. Exp. Neurol. 60: 984-993 (2001)

Blümcke I Beck H Lie AA Wiestler OD
Molecular neuropathology of human mesial temporal lobe epilepsy.
Epilepsy Res, 36, 205-223 (1999)

Blümcke I, Beck H, Suter B, Hoffmann D, Fodisch HJ, Wolf HK, Schramm J, Elger CE, Wiestler OD
An increase of hippocampal calretinin-immunoreactive neurons correlates with early febrile seizures in temporal lobe epilepsy.
Acta Neuropathol, 97, 31-39 (1999)

Blümcke I, Giencke K, Wardelmann E, Beyenburg S, Kral T, Sarioglu N, Pietsch T, Wolf HK, Schramm J, Elger CE, Wiestler OD
The CD34 epitope is expressed in neoplastic and malformative lesions associated with chronic, focal epilepsies.
Acta Neuropathol, 97, 481-490 (1999)

Blümcke I, Giencke K, Wardelmann E, Beyenburg S, Sarioglu N, Pietsch T, Wolf HK, Schramm J, Elger CE, Wiestler OD
The CD34 epitope is expressed in neoplastic and malformative lesions associated with chronic, focal epilepsies.
Acta Neuropathol. 97, 481-90 (1999)

Blümcke I Löbach M Wolf HK Wiestler OD
Evidence for developmental precursor lesions in epilepsy-associated glioneuronal tumors.
Microsc Res Tech, 46, 53-58 (1999)

Blümcke I, Schewe J.C, Normann S, Brüstle O, Schramm J, Elger C.E, Wiestler O.D
Increase of nestin-immunoreactive cells in the dentate gyrus of pediatric patients with early onset temporal lobe epilepsy.
Hippocampus 11: 311-321 (2001)

Blümcke I Suter B Behle K Kuhn R Schramm J Elger CE Wiestler OD
Loss of hilar mossy cells in Ammon's horn sclerosis.
Epilepsia 41, 174-180 (2000)

Blümcke I, Zuschratter W, Schewe JC, Suter B, Lie AA, Riederer BM, Meyer B, Schramm J, Elger CE, Wiestler OD
Cellular pathology of hilar neurons in Ammon's horn sclerosis.
J Comp Neurol, 414, 437-453 (1999)

Boström J, Janßen G, Messing-Jünger M, Felsberg JU, Neuen-Jacob E, Engelbrecht V, Lenard HG, Bock WJ, Reifenberger G
Multiple intracranial juvenile xanthogranulomas. Case report.
J Neurosurg 93, 335-341 (2000)

Bostrom J, Meyer-Puttlitz B, Wolter M, Blaschke B, Weber RG, Lichter P, Ichimura K, Collins VP, Reifenberger G
Alterations ot the tumor suppressor genes CDKN2A (p16(INK4a)), p14 (ARF), CDKN2B (p15(INK4b)), and CDKN2C (p18(INK4c) in atypical and anaplastic meningeomas.
Am J Pathol.; 159 (2): 661-9 (2001)

Bouterfa H Darlapp A-R Klein E Pietsch T Roosen K Tonn JC
Expression of different extracellular matrix components in human brain tumor and melanoma cells in respect to variant culture conditions.
J. Neuro-Oncol. 44, 23-33 (1999)

Brat DJ Scheithauer BW Cortez SC Reifenberger G Burger PC
Chordoid glioma of the third ventricle. In Pathology and genetics of tumors of the nervous system, WHO Classification of Tumours. 2nd Edition. Edited by P. Kleihues, W. Cavenee.
International Agency for Research on Cancer; Lyon, pp 90-91 (2000)

Brüstle CO Wiestler OD
Zellersatz aus embryonalen Stammzellen: Neue Perspektiven für die Transplantationsmedizin.
Dt Ärzteblatt, 97, 1258-1263 (2000)

Brüstle O
Building brains: Neural chimeras in the study of nervous system development and repair.
Brain Pathol. 9, 527-45 (1999)

Brüstle O
Embryonale Stammzellen: Neue Perspektiven für die Transplantationsmedizin.
Fortpflanzungsmedizin in Deutschland, Schriftenreihe des Bundesministeriums für Gesundheit. Nomos Verlagsgesellschaft Baden-Baden, pp. 222-227 (2001)

Brüstle O
Embryonale Stammzellen - neue Perspektiven für die Transplantationsmedizin.
Humane Stammzellen. Perspektiven und Grenzen in der regenerativen Medizin, Bundesministerium für Bildung und Forschung (eds.), Schattauer Verlagsgesellschaft mbH, Stuttgart pp. 107-118 (2001)

Brüstle O Dubois-Dalcq M
CNS stem cells and their gliogenic potential.
Glial Cell Development: Basic Principles and Clinical Relevance, Jessen KR, Richardson WD (eds.), Oxford University Press, pp.415-436 (2001)

Brüstle O, Jones KN, Learish RD, Karram K, Choudhary K, Wiestler OD, Duncan ID, McKay RDG
Embryonic stem cell-derived glial precursors: a source of myelinating transplants.
Science 285, 754-56 (1999)

Brüstle O Karram K Buschwald R Wiestler OD
Embryonale Stammzellen: neue Perspektiven für den Zellersatz im zentralen Nervensystem. In: JW Dudenhausen, E Schwinger, Reproduktionsmedizin: Möglichkeiten und Grenzen.
Medizinische Verlagsgesellschaft Umwelt & Medizin mbH, Frankfurt, p. 87-94 (2000)

Bühren J Christoph AHA Buslei R Albrecht S Wiestler OD Pietsch T
Expression of the neurotrophin receptor p75-NTR in medulloblastomas is correlated to distinct histological and clinical features: Evidence for a medulloblastoma subtype derived from the external granule cell layer.
J Neuropathol Exp Neurol 59, 229-240 (2000)

Büschges R Weber RG Actor B Lichter P Collins VP Reifenberger G
Amplification and expression of cyclin D genes (CCND1, CCND2, and CCND3) in human malignant gliomas.
Brain Pathol 9, 435-443 (1999)

Chen J Sochivko D Beck H Marechal D Wiestler OD Becker AJ
Activity-induced expression of common reference genes in individual CNS neurons.
Lab Invest 81(6): 913-916, 2001 (2001)

Codina C Kraft R Pietsch T Prinz M Steinhäuser C Cervos-Navarro J Patt S
Voltage- and GABA-activated membrane currents in the human medulloblastoma cell line MHH-MED-3.
Neurosci Letters 287, 53-56 (2000)

Csuka E, Hans VH, Ammann E, Trentz O, Kossmann T, Morganti-Kossmann MC
Cell activation and inflammatory response following traumatic axonal injury in the rat.
Neuroreport 2000;11:2587-90

Czygan M, Hallensleben W, Hofer M, Pollak S, Sauder C, Bilzer T, Blümcke I, Riederer P, Bogerts B, Falkai P, Schwarz MJ, Masliah E, Staeheli P, Hufert FT, Lieb K
Borna disease virus in human brains with a rare form of hippocampal degeneration but not in brains of patients with common neuropsychiatric disorders.
J Infect Dis, 180, 1695-9 (1999)

Dahmen RP, Koch A, Denkhaus D, Tonn JC, Sörensen N, Berthold F, Behrens J, Birchmeier W, Wiestler OD, Pietsch T
Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas.
Cancer Res 61, 7039-43 (2001)

Daumas-Duport C Pietsch T Lantos PL
Dysembryoplastic neuroepithelial tumors. In: Kleihues P, Cavenee W, eds. Pathology and genetics of tumours of the central nervous system, WHO Classification of Tumours. 2nd edition.
IARC Press, Lyon, 103-106 (2000)

Deckert-Schluter M Bluethmann H Kaefer N Rang A Schluter D
Interferon-gamma receptor-mediated but not tumor necrosis factor receptor type 1- or type 2-mediated signaling is crucial for the activation of cerebral blood vessel endothelial cells and microglia in murine Toxoplasma encephalitis.
Am J Pathol 154, 1549-61 (1999)

Deckert-Schluter M Buck C Schluter D
Kinetics and differential expression of heat-stable antigen and GL7 in the normal and Toxoplasma gondii-infected murine brain.
Acta Neuropathol 98, 97-106 (1999)

Dettmeyer R. Driever F. Becker A. Wiestler O.D. Madea B
Fatal myeloencephalopathy due to accidental intrathecal vincristin administration: a report of two cases.
Forensic Sci. Int. 122: 60-64 (2001)

Diehlmann A Ida N Weggen S Gruenberg J Haas C Masters CL Bayer TA Beyreuther K
Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies.
J Neurosci Res 56, 405-19 (1999)

Dietrich D Clusmann H Kral T Steinhauser C Blümcke I Heinemann U Schramm J
Two electrophysiologically distinct types of granule cells in epileptic human hippocampus.
Neuroscience, 90, 1197-1206 (1999)

Ebert C von Haken M Meyer-Puttlitz B Wiestler OD Reifenberger G Pietsch T von Deimling A
NF2 mutations and allelic loss of chromosome 22q in ependymal tumors: Association with intramedullary spinal localization.
Am. J. Pathol. 155, 627-32 (1999)

E Csuka VH Hans E Ammann O Trentz T Kossmann MC Morganti-Kossmann
Cell activation and inflammatory response following traumatic axonal injury in the rat.
Neuroreport 11, 2587-2590 (2000)

Egensperger R Weggen S Ida N Multhaup G Schnabel R Beyreuther K Bayer TA
Reverse relationship between APP and ßA4 plaques in Down syndrome versus sporadic/familial Alzheimer´s disease.
Acta Neuropathol 97, 113-118 (1999)

El-Shabrawi Y Radner H Muellner K Langmann G Höfler G
The role of UV-radiation in the development of conjunctival malignant melanoma.
Acta Ophthalmol 77, 31-32 (1999)

Eriksson T, Frisk T, Gray SG, von Schweinitz D, Pietsch T, Larsson C, Sandstedt B, Ekström TJ
Methylation changes in the human igf2 p3 promoter parallel igf2 expression in the primary tumor, established cell line, and xenograft of a human hepatoblastoma.
Exp Cell Res 270, 88-95 (2001)

Faiella A, Wernig M, Consalez GC, Hostik U, Hofmann C, Hustert E, Boncinelli E, Balling R, Nadeau JH
A mouse model for valproate teratogenicity: parental effects, homeotic transformations, and altered HOX expression.
Hum Mol Genet 9, 227-236 (2000)

Felsberg J Reifenberger G
Neuropathologie und molekulare Grundlagen von Metastasen im zentralen Nervensystem.
Onkologe 6, 919-929 (2000)

Frühwald MC, O'Dorisio MS, Dai Z, Rush LJ , Krahe R, Smiraglia DJ, Pietsch T, Elsea SH, Plass C
Aberrant hypermethylation of the major breakpoint cluster region in 17p11.2 in medulloblastomas but not supratentorial PNETs.
Genes Chromosomes Cancer 30, 38-47 (2001)

Frühwald MC O'Dorisio MS Fleitz J Pietsch T Reubi JC
Vasoactive intestinal peptide: growth modulator in central primitive neuroectodermal tumors of childhood.
Int. J. Cancer 12, 165-73 (1999)

Frühwald MC O'Dorisio MS Pietsch T Reubi JC
High expression of somatostatin receptor subtype 2 (SST2) in medulloblastoma - Implications for diagnosis and therapy.
Pediatr. Res. 45, 697-708 (1999)

Fulda S Jeremias I Pietsch T Debatin K-M
Betulinic acid: a new chemotherapeutic agent in the treatment of neuroectodermal tumors.
Klin. Pädiatr. 211, 19-22 (1999)

Fulda S Jeremias I Steiner HH Pietsch T Debatin K-M
Betulinic acid: a new cytotoxic agent against malignant brain tumor cells.
Int. J. Cancer 82, 435-41 (1999)

Gerdes B Ramaswamy A Simon B Pietsch T Bastian D Kersting M Moll R Bartsch D
Analysis of beta-catenin gene mutations in pancreatic tumors.
Digestion 60, 544-548 (1999)

Ghebremedhin E Schultz C Thal DR Rüb U Ohm TG Braak E Braak H
Gender and age modify the association between APOE and AD-related neuropathology.
Neurology 56, 1696-1701 (2001)

Ghebremedhin E, Schultz C, Thal DR, Rub U, Ohm TG, Braak E, Braak H
Gender and age modify the association between APOE and AD-related neuropathology.
Neurology (2001) 56: 1696-1701.

Giangaspero F Bigner SH Kleihues P Pietsch T Trojanowski PQ
Medulloblastoma. In: Kleihues P, Cavenee W, eds. Pathology and genetics of tumours of the central nervous system, WHO Classification of Tumours. 2nd edition.
IARC Press, Lyon, 129-137 (2000)

Gilbertson R, Hernan R, Pietsch T, Pinto L, Scotting P, Allibone R, Ellison D, Perry R, Pearson A, Lunec J
Novel ERBB4 juxtamembrane splice variants are frequently expressed in childhood medulloblastoma.
Genes Chromosomes Cancer 31, 288-94 (2001)

Giordana MT Wiestler OD
Medullomyoblastoma. In Pathology and genetics of tumors of the nervous system, WHO Classification of Tumours. 2nd Edition. Edited by P. Kleihues, W. Cavenee.
International Agency for Research on Cancer; Lyon, pp 138-139 (2000)

Gnekow AK Kaatsch P. Kortmann R Wiestler OD
HIT-LGG: Effektivität von Carboplatin-Vincristin bei progredienten Gliomen niedrigen Malignitätsgrades im Kindesalter - Zwischenbericht.
Klin Pädiatrie 212,177-184 (2000)

Goldbrunner RH , Vince GH , Bernstein JJ , Pietsch T , Wagner S , Hagemann H , Selby DM , Krauss J, Sörensen N, Tonn J-C
Different vascular patterns of medulloblastoma and supratentorial primitive neuroectodermal tumors.
Int. J. Dev. Neurosci. 17, 593-599 (1999)

Gray SG, Eriksson T, Ekström C, Holm S , von Schweinitz D, Kogner P, Sandstedt B, Pietsch T, Ekström TJ
Decreased expression of insulin-like growth factor binding proteins 1 and 2 in hepatoblastomas; Role of IGF-axis components.
Br J Cancer 82, 1561-1567 (2000)

Gray SG, Hartmann W, Eriksson T, Ekström C, Holm S, Kytölä S, von Schweinitz D, Pietsch T, Larsson C, Kogner P, Sandstedt B, Ekström TJ
Expression of genes involved with cell cycle control cell growth and chromatin modification are altered in hepatoblastomas.
Int J Mol Medicine 6, 161-169 (2000)

Grunwald T, Beck H, Lehnertz K, Blumcke I, Pezer N, Kurthen M, Fernandez G, Van Roost D, Heinze HJ, Kutas M, Elger CE
Evidence relating human verbal memory to hippocampal N-methyl-D- aspartate receptors.
Proc Natl Acad Sci U S A, 96, 12085-12089 (1999)

Grunwald T, Beck H, Lehnertz K, Blümcke I, Pezer N, Kutas M, Kurthen M, Karakas HM, Van Roost D, Wiestler OD, Elger CE
Limbic P300s in temporal lobe epilepsy with and without Ammon's horn sclerosis.
Eur J Neurosci, 11, 1899-1906 (1999)

Hans VH, Kossmann T, Joller H, Otto V, Morganti-Kossmann MC
Interleukin-6 and its soluble receptor in serum and cerebrospinal fluid after cerebral trauma.
Neuroreport 1999;10:409-12

Hans VH, Kossmann T, Joller H, Otto V, Morganti-Kossmann MC
Interleukin-6 and its soluble receptor in serum and cerebrospinal fluid after cerebral trauma.
Neuroreport 10, 409-12 (1999)

Hans VH, Kossmann T, Lenzlinger PM, Probstmeier R, Imhof HG, Trentz O, Morganti-Kossmann MC
Experimental axonal injury triggers interleukin-6 mRNA, protein synthesis and release into cerebrospinal fluid.
J Cereb Blood Flow Metab 1999;19:184-94

Hans VH, Kossmann T, Lenzlinger PM, Probstmeier R, Imhof HG, Trentz O, Morganti-Kossmann MC
Experimental axonal injury triggers interleukin-6 mRNA, protein synthesis and release into cerebrospinal fluid.
J Cereb Blood Flow Metab 19, 184-94 (1999)

Hartmann W, Waha A, Koch A, Albrecht S, von Schweinitz D, Pietsch T
p57-KIP2 is not mutated in hepatoblastoma but shows increased transcriptional activity - a comparative analysis of three imprinted genes p57-KIP2, IGF2, and H19.
Am J Pathol 157, 1393-1403 (2000)

Herms J, Neidt I, Lüscher B, Sommer A, Schürmann P, Schröder T, Bergmann M, Wilken B, Probst-Cousin S, Herna'iz-Driever P, Behnke J, Hanefeld F, Pietsch T, Kretzschmar HA
c-myc expression in medulloblastoma and its prognostic value.
Int J Cancer 89, 395-402 (2000)

Hinterkeuser S, Schröder W, Hager G, Seifert G, Blümcke I, Elger CE, Schramm J, Steinhäuser C
Astrocytes in the hippocampus of patients with temporal lobe epilepsy display changes in potassium conductances.
Eur J Neurosci 12, 2087-2096 (2000)

Hochman J., Assaf N., Deckert-Schlüter M., Wiestler O.D., Pe'er J
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Cancer Res. 61: 5242-5247 (2001)

Husemann K, Wolter M, Büschges R, Boström J, Reifenberger G
Identification of two distinct deleted regions on the short arm of chromosome 1 and rare mutation of the CDKN2C gene at 1p32 in oligodendroglial tumors.
J Neuropathol Exp Neurol 58, 1041-1050 (1999)

Ishii N, Tada M, Daub DM, Hamou MF, Janzer RC, Meagher-Villemure K, Wiestler OD, de Tribolet N, van Meir E
Cells with TP53 mutations in low grade astrocytic tumors evolve clonally to malignancy and are an unfavorable prognostic factor.
Oncogene 18, 5870-5878 (1999)

Jeub M, Lie A, Blümcke I, Elger CE, Beck H
Loss of dynorphin-mediated inhibition of voltage-dependent Ca2+ currents in hippocampal granule cells isolated from epilepsy patients is associated with mossy fiber sprouting.
Neuroscience, 94, 465-471 (1999)

Joachim T., Ram Z., Rappaport Z.H., Simon M., Schramm J., Wiestler O.D., von Deimling A
Comparative analysis of the NF2, TP53, PTEN, KRAS, NRAS and HRAS genes in sporadic and radiation induced human meningiomas.
Int. J. Cancer 94: 218-221 (2001)

Kappler R, Pietsch T, Weggen S, Wiestler OD, Scherthan H
High-level DNA amplification in neural cell lines derived from SV40 large T-induced primitive neuroectodermal tumors.
Carcinogenesis 20, 1433-38 (1999)

Kastenbauer S, Danek A, Klein W, Yousry T, Bise K, Reifenberger G, Pfister HW
Primary diffuse leptomeningeal gliomatosis: unusual MRI with cystic lesions on the cerebellar surface and spinal but not intracranial leptomeningeal enhancement.
J Neurol Neurosurg Psychiatry 69, 385-388 (2000)

Kelkenberg U, von Rautenfeld DB , Brinker T, Hans VH
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Kelkenberg U, von Rautenfeld DB, Brinker T, Hans VH
Chicken arachnoid granulations: a new model for cerebrospinal fluid absorption in man.
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Kirches E, Krause G, Warich-Kirches M, Schneider T, Meyer-Puttlitz B, Mawrin C, Dietzmann K
High frequency of mitochondrial DNA mutations in glioblastoma multiforme identified by direct sequence comparison to blood samples.
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Knez I, Cerwenka H, Moinfar F, Hoff M, Mächler H, Anelli-Monti M, Radner H, Rigler B
Invasive ductal carcinoma of the male breast expanding from pacemaker pocket decubitus.
PACE 22, 531-33 (1999)

Koch A, Denkhaus D, Albrecht S, Leuschner I, von Schweinitz D, PietschT
Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene.
Cancer Res. 59, 269-273 (1999)

Koch A, Waha A, Tonn JC, Sörensen N, Berthold F, Wolter M, Reifenberger J, Hartmann W, Friedl W, Reifenberger G, Wiestler OD, Pietsch T
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Int J Cancer 93, 445-9 (2001)

Kortmann RD, Kühl J, Timmermann B, Mittler U, Urban C, Budach V, Richter E, Willich N, Flentje M, Berthold F, Slavc I, Wolff J, Meisner C, Wiestler O, Sörensen N, Warmuth-Metz M, Bamberg M
Postoperative neoadjuvant chemotherapy before radiotherapy as compared to maintenance chemotherapy after radiotherapy in the treatment of medulloblastoma in childhood : Results of the German prospective randomized trial HIT '91
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Kral, T, Kuczaty, S, Blümcke, I, Urbach, H, Clusmann, H, Wiestler, O.D, Elger, C, Schramm, J
Postsurgical outcome of children and adolescents with medically refractory frontal lobe epilepsies.
Childs Nerv Syst 17: 595-601 (2001)

Kraus JA, de Millas W, Sörensen N, Herbold C, Schichor C, Tonn JC, Wiestler OD, von Deimling A, Pietsch T
Indications for a tumor suppressor gene at 22q11 involved in the pathogenesis of ependymal tumors and distinct from hSNF5/INI1.
Acta Neuropathol 102, 69-74 (2001)

Kraus JA, Lamszus K, Glesmann N, Beck M, Wolter M, Sabel M, Krex D, Klockgether T, Reifenberger G, Schlegel U
Molecular genetic alterations in glioblastomas with oligodendroglial component.
Acta Neuropathol 101: 311-320 (2001)

Kraus JA, Wenghoefer M, Schmidt M, von Deimling A, Berweiler U, Roggendorf W, Diete S, Dietzmann K, Müller B, Heuser K, Reifenberger G, Schlegel U
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J Neurol 247, 455-460 (2000)

Kukekov VG, Laywell ED, Suslov O, Davies K, Scheffler B, Thomas LB, O'Brien TF, Kusakabe M, Steindler DA
Multipotent stem/progenitor cells with similar properties arise from two neurogenic regions of adult human brain.
Exp Neurol, 156, 333-344 (1999)

Kuklinski S, Pesheva P, Heimann C, Urschel S, Gloor S, Graeber S, Herzog V, Pietsch T, Wiestler OD, Probstmeier R
Expression pattern of galectin-3 in neural tumor cell lines.
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Kunz WS, Kudin AP, Vielhaber S, Blümcke I, Zuschratter W, Schramm J, Beck H, Elger CE
Mitochondrial complex I deficiency in the epileptic focus of patients with temporal lobe epilepsy.
Ann Neurol 48, 766-773 (2000)

Learish RD, Brüstle O, Zhang SC, Duncan ID
Intraventricular transplantation of oligodendrocyte progenitors into a fetal myelin mutant results in widespread formation of myelin.
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Lehmann LE, Novender U, Schroeder S, Pietsch T , von Spiegel T, Putensen C, Hoeft A, Stuber F
Plasma levels of macrophage migration inhibitory factor are elevated in patients with severe sepsis.
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Lenzlinger PM, Hans VH, Joller-Jemelka HI, Trentz O, Morganti-Kossmann MC, Kossmann T
Markers for cell-mediated immune response are elevated in cerebrospinal fluid and serum after severe traumatic brain injury in humans.
J Neurotrauma 2001;18:479-89

Lenzlinger PM, Hans VH, Joller-Jemelka HI, Trentz O, Morganti-Kossmann MC, Kossmann T
Markers for cell-mediated immune response are elevated in cerebrospinal fluid and serum after severe traumatic brain injury in humans.
J Neurotrauma, 479-489 (2001)

Levak-Frank S, Hofmann W, Weinstock PH, Radner H, Sattler W, Breslow JL, Zechner R
Induced mutant mouse lines that express lipoprotein lipase in cardiac muscle, but not in skeletal muscle and adipose tissue, have normal plasma triglyceride and high-density lipoprotein-cholesterol levels.
Proc Natl Acad Sci 96, 3165-70 (1999)

Lie AA, Becker A, Behle K, Beck H, Malitschek B, Conn PJ, Kuhn R, Nitsch R, Plaschke M, Schramm J, Elger CE, Wiestler OD, Blümcke I
Up-regulation of the metabotropic glutamate receptor mGluR4 in hippocampal neurons with reduced seizure vulnerability.
Ann Neurol 47, 26-35 (2000)

Lie AA, Blümcke I, Beck H, Wiestler OD, Elger CE, Schoen SW
5'-Nucleotidase activity indicates sites of synaptic plasticity and reactive synaptogenesis in the human brain.
J Neuropathol Exp Neurol, 58, 451-458 (1999)

Lie AA, Blümcke I, Volsen SG, Wiestler OD, Elger CE, Beck H
Distribution of voltage-dependent calcium channel beta subunits in the hippocampus of patients with temporal lobe epilepsy.
Neuroscience, 93, 449-456 (1999)

Louis DN Stemmer-Rachamimov AO Wiestler OD
Neurofibromatosis type 2. In Pathology and genetics of tumors of the nervous system, WHO Classification of Tumours. 2nd Edition. Edited by P. Kleihues, W. Cavenee.
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Mai JK Krajewski S Reifenberger G Genderski B Lensing-Höhn S Ashwell KWS
Spatiotemporal expression gradients of an adhesion molecule associated epitope (CD15) during development of the human basal ganglia.
Neuroscience 88, 847-858 (1999)

Maskos U Brüstle O McKay RDG
Long-term survival, migration, and differentiation of neural cells without functional NMDA receptors in vivo.
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MC Sabel VH Hans G Reifenberger
Mixed gangliocytoma/pituitary adenoma.
Arch Neurol 57, 587-588 (2000)

Montesinos-Rongen M, Hans VH, Eis-Hubinger AM, Prinz M, Schaller C, Van Roost D, Aguzzi A, Wiestler OD, Deckert M
Human herpes virus-8 is not associated with primary central nervous system lymphoma in HIV-negative patients.
Acta Neuropathol 2001;102:489-95

Montesinos-Rongen M, Hans VH, Eis-Hubinger AM, Prinz M, Schaller C, Van Roost D, Aguzzi A, Wiestler OD, Deckert M
Human herpes virus-8 is not associated with primary central nervous system lymphoma in HIV-negative patients.
Acta Neuropathol (Berl), 489-495 (2001)

Montesinos-Rongen M, Küppers R, Schlüter D, Spieker T, van Roost D, Schaller C, Reifenberger G, Wiestler OD, Deckert-Schlüter M
Primary central nervous system lymphomas are derived from germinal center B cells and show preferential usage of the V4-34 gene segment.
Am J Pathol 155, 2077-2086 (1999)

Morganti-Kossmann MC Hans VH Lenzlinger PM Dubs R Ludwig E Trentz O Kossmann T
TGF-beta is elevated in the CSF of patients with severe traumatic brain injuries and parallels blood-brain barrier function.
J Neurotrauma 16: 617-28 (1999)

Morganti-Kossmann MC, Hans VH, Lenzlinger PM, Dubs R, Ludwig E, Trentz O, Kossmann T
TGF-beta is elevated in the CSF of patients with severe traumatic brain injuries and parallels blood-brain barrier function.
J Neurotrauma 1999;16:617-28

M Simon TW Park S Leuenroth VH Hans T Loning J Schramm
Telomerase activity and expression of the telomerase catalytic subunit, hTERT, in meningioma progression.
J Neurosurg 92, 832-40 (2000)

Müller MB, Schmidt MC, Schmidt O, Hayashi Y, Rollbrocker B, Waha A, Fimmer R, Volk B, Warnke PC, Ostertag CB, Wiestler OD, von Deimling A
Molecular genetic analysis as a tool for evaluating stereotactic biopsies of glioma specimens.
J Neuropathol Exp Neurol 58, 40-45 (1999)

Nelson JS Bruner JM Wiestler OD VandenBerg SR
Ganglioglioma and gangliocytoma. In Pathology and genetics of tumors of the nervous system, WHO Classification of Tumours. 2nd Edition. Edited by P. Kleihues, W. Cavenee.
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Nessling M, Solinas-Toldo S, Bentz M, Wolter M, Reifenberger G, Döhner H, Möller P, Lichter P
Genomic imbalances are rare in hairy cell leukemia.
Genes Chromosomes Cancer 26, 182-183 (1999)

Oehring RD, Miletic M, Valter MM, Pietsch T, Neumann J, Fimmers R, Schlegel U
Vascular endothelial growth factor (VEGF) in malignant glioma - a prognostic factor?
J Neuro-Oncol 45, 117-125 (2000)

Paulus W Jellinger K Morgello S Deckert-Schlüter M
Malignant lymphomas. In Pathology and genetics of tumors of the nervous system, WHO Classification of Tumours. 2nd Edition. Edited by P. Kleihues, W. Cavenee.
International Agency for Research on Cancer; Lyon, pp 198-203 (2000)

Pels H, Deckert-Schlüter M, Glasmacher A, Kleinschmidt R, Oehring R, Fischer HP, Bode U, Schlegel U
Primary central nervous system lymphoma: a clinico-pathological study of 28 cases.
Hematol Oncol 18, 21-32 (2000)

Peters N, Waha A, Wellenreuther R, Friedrich RE, Mautner VF, Hoffmeyer S, Lenartz D, Schramm J, Wiestler OD, von Deimling A
Quantitative analysis of NF1 and OMGP gene transcripts in sporadic gliomas, sporadic meningiomas, and neurofibromatosis typpe 1-associated plexiform neurofibromas.
Acta Neuropathol 97, 547-551 (1999)

Przkora R, Meyer-Puttlitz B, Schmitt O, Berthold F, Nöthen M, Krauss J, Tonn JC, von Deimling A, Wiestler OD, Pietsch T
Analysis of the TSC2 gene in human medulloblastoma.
Acta Neuropathol 102, 380-4 (2001)

Radner H, Deckert-Schlüter M, Pietsch T, Reifenberger G, Wiestler OD
New developments in the neuropathology of skull base neoplasms. In Fahlbusch R, Buchfelder M (Eds.) The Centre of the Skull Base.
Einhorn-Presse Verlag, Reinbek, pp 137-150 (2000)

Radner H, Katenkamp D, Reifenberger G, Deckert M, Pietsch T, Wiestler OD
New developments in the pathology of skull base tumors.
Virchows Arch 438, 321-35 (2001)

Rancan M, Otto VI, Hans VH, Gerlach I, Jork R, Trentz O, Kossmann T, Morganti-Kossmann MC
Upregulation of ICAM-1 and MCP-1 but not of MIP-2 and sensorimotor deficit in response to traumatic axonal injury in rats.
J Neurosci Res 2001;63:438-46

Rancan M, Otto VI, Hans VH, Gerlach I, Jork R, Trentz O, Kossmann T, Morganti-Kossmann MC
Upregulation of ICAM-1 and MCP-1 but not of MIP-2 and sensorimotor deficit in response to traumatic axonal injury in rats.
J Neurosci Res, 438-446 (2001)

Reifenberger G Kros JM Burger PC Louis DN Collins VP
Oligodendroglioma. In Pathology and genetics of tumors of the nervous system, WHO Classification of Tumours. 2nd Edition. Edited by P. Kleihues, W. Cavenee.
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Reifenberger G Kros JM Burger PC Louis DN Collins VP
Anaplastic oligodendroglioma. In Pathology and genetics of tumors of the nervous system, WHO Classification of Tumours. 2nd Edition. Edited by P. Kleihues, W. Cavenee.
International Agency for Research on Cancer; Lyon, pp 62-64 (2000)

Reifenberger G Kros JM Burger PC Louis DN Collins VP
Oligoastrocytoma. In Pathology and genetics of tumors of the nervous system, WHO Classification of Tumours. 2nd Edition. Edited by P. Kleihues, W. Cavenee.
International Agency for Research on Cancer, Lyon, pp 65-67 (2000)

Reifenberger G Kros JM Burger PC Louis DN Collins VP
Anaplastic oligoastrocytoma. In Pathology and genetics of tumors of the nervous system, WHO Classification of Tumours. 2nd Edition. Edited by P. Kleihues, W. Cavenee.
International Agency for Research on Cancer; Lyon, pp 68-69 (2000)

Reifenberger G, Weber T, Weber RG, Wolter M, Brandis A, Kuchelmeister K, Pilz P, Reusche E, Lichter P, Wiestler OD
Chordoid glioma of the third ventricle: Immunohistochemical and molecular genetic characterization of a novel tumor entity.
Brain Pathol 9, 617-626 (1999)

Reifenberger G Wiestler OD Chenevix-Trench G
Naevoid basal cell carcinoma syndrome. In Pathology and genetics of tumors of the nervous system, WHO Classification of Tumours. 2nd Edition. Edited by P. Kleihues, W. Cavenee.
International Agency for Research on Cancer, Lyon, pp 240-241 (2000)

Riazanski V, Becker AJ, Chen J, Sochivko D, Lie A, Wiestler OD, Elger CE, Beck H
Functional and molecular analysis of transient voltage-dependent K (currents in hippocampal granule cells.
J Physiol 537(2): 391-406, 2001 (2001)

Riemenschneider MJ, Büschges R, Wolter M, Reifenberger J, Boström J, Kraus JA, Schlegel U, Reifenberger G
Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 and MDM2 amplification.
Cancer Res 59, 6091-6096 (1999)

Rüb U Del Tredici K Schultz C Thal DR Braak E Braak H
The autonomic higher order processing nuclei of the lower brain stem are among the early targets of the Alzheimer's disease-related cytoskeletal pathology.
Acta Neuropathol 101, 555-64 (2001)

Rüb U, Del Tredici K, Schultz C, Thal DR, Braak E, Braak H
The evolution of Alzheimer?s disease-related cytoskeletal pathology in the human raphe nuclei.
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Rüb U, Del Tredici K, Schultz C, Thal DR, Braak E, Braak H
The autonomic higher order processing nuclei of the lower brain stem are among the early targets of the Alzheimer?s disease-related cytoskeletal pathology.
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Rudlowski C Rath W Becker AJ Wiestler OD Büttner R
Trastuzumab and breast cancer.
New Engl J Med 345 (13): 997-998, 2001 (2001)

Sabel MC, Hans VH, Reifenberger G
Mixed gangliocytoma/pituitary adenoma.
Arch Neurol 2000;57:587-8

Salewski H, Bayer TA, Eidhoff U, Preuss U, Weggen S, Wiestler OD, Scheidtmann KH
Increased oncogeneicity of subclones of SV40-large T induced neuroectodermal tumor cell lines after loss of large T expression and concomitant mutation in p53.
Cancer Res 59, 1980-1986 (1999)

Sarbia M, Loberg C, Wolter M, Arjumand J, Heep H, Reifenberger G, Gabbert HE
Expression of Bcl-2 and amplification of C-MYC are frequent in basaloid squamous cell carcinomas of the esophagus.
Am J Pathol 155, 1027-1032 (1999)

Sassin I, Schultz C, Thal DR, Rüb U, Arai K, Braak E, Braak H
Evolution of Alzheimer's disease-related cytoskeletal changes in the basal nucleus of Meynert.
Acta Neuropathol. 100 (2000) 259-269

Sauerwein W. , Hideghety K. , Wiestler O.D., Pignol. J.-P., Bendel P
EORTC clinical trials for boron neutron capture therapy BNCT.
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Sauerwein W., Hideghety K, Rassow J., Devries M.J., Götz C., Paquis P., Grochulla F., Wolbers J.G., Haselsberger K., Turowski B., Moss R.L., Stecher-Rasmussen F., Touw D., Wiestler O.D., Fankhauser H., Gabel D
First clinical results from the EORTC phase I trial: postoperative treatment of glioblastoma with BNCT at the Petten irradiation facility.
IAEA-TECDOC-1223, p. 250-256 (2001)

Sauerwein W. , Moss R. , Wiestler O.D. , Fankhauser H. , Gabel D
Status report on the European clinical trial of BNCT at Petten (EORTC protocol 11961) In: Frontires in Neutron Capture Therapy.
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Scheffler B, Horn M, Blümcke I, Laywell ED, Coomes D, Kukekov VG, Steindler DA
Marrow-mindedness: a perspective on neuropoiesis.
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Schlegel U Pels H Oehring R Blümcke I
Neurologic sequelae of treatment of primary CNS lymphomas.
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Schlegel U Schmidt-Wolf IG Deckert M
Primary CNS lymphoma: clinical presentation, pathological classification, molecular pathogenesis and treatment.
J Neurol Sci 181, 1-12 (2000)

Schlüter D Deckert M
The divergent role of tumor necrosis factor receptors in infectious diseases.
Microbes Inf 2, 1290-1292 (2000)

Schluter D, Deckert-Schluter M, Lorenz E, Meyer T, Rollinghoff M, Bogdan C
Inhibition of inducible nitric oxide synthase exacerbates chronic cerebral toxoplasmosis in Toxoplasma gondii susceptible C57BL/6 mice but does not reactivate the latent disease in T. gondii-resistant BALB/c mice.
J Immunol 162 (1999)

Schlüter D, Meyer T, Strack A, Reiter S, Kretschmar M, Wiestler OD, Hof H, Deckert M
Regulation of microglia by CD4+ and CD8+ T cells: selective analysis of microglial cell surface antigen expressionand cytokine production in CD45-congenic normal and Toxoplasma-infected bone marrow chimeras.
Brain Pathol 11, 44-55 (2000)

Schmidt S, Hertfelder HJ, von Spiegel T, Hering R, Harzheim M, Lassmann H, Deckert-Schluter M, Schlegel U
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Schneider W, Kellermann S, Nenning H, Thal DR, Schober R
Zytophotometrische Untersuchungen an Rezidivgliomen. Korrelation der DNA-Parameter mit dem WHO-Grad, dem Proliferationsindex und der Länge der rezidivfreien Intervalle.
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Schramm, J Kral, T Grunwald, T Blümcke, I
Surgical treatment for neocortical temporal lobe epilepsy: clinical and surgical aspects and seizure outcome.
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Schramm J Kral T Blümcke I Elger CE
Surgery for neocortical temporal and frontal epilepsy.
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Schramm M Falkai P Pietsch T Neidt I Egensperger R Bayer TA
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Schramm M, Falkai P, Tepest R, Schneider-Axmann T, Rrzkora R, Waha A, Pietsch T, Bayer TA
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Schröder R, Warlo I, Herrmann H , van der Ven PF, Klasen C, Blümcke I, Mundegar RR, Furst DO, Goebel HH, Magin TM
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Schultz C, Dehghani F, Hubbard GB, Thal DR, Struckhoff G, Braak E, Braak H
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Schumacher TB Beck H Steffens R Blümcke I Schramm J Elger CE Steinhauser C
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Epilepsia 41, 1249-1258 (2000)

Simon M, Park TW, Leuenroth S, Hans VH, Loning T, Schramm J
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J Neurosurg 2000;92:832-40

Smyth I, Narang MA , Evans T, Heimann C, Nakamura Y, Chenevix-Trench G, Pietsch T, Wicking C, Wainwright BJ
Isolation and characterization of human Patched 2 (PTCH2), a gene mutated in medulloblastoma.
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Sommer A, Koch A, Tonn J, Sörensen N, Hurlin P, Lüscher B, Pietsch T
Analysis of the Max binding protein Mnt in human medulloblastomas.
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Stan A-C, Walter GF, Welte K, Schneider B, Bona CA, Pietsch T
Expression of granulocyte colony-stimulating factor (G-CSF) in recurrent glial tumors is inversely correlated with tumor progression.
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Steckelbroeck S, Heidrich DD, Stoffel-Wagner B, Hans VH, Schramm J, Bidlingmaier F, Klingmuller D
Characterization of aromatase cytochrome P450 activity in the human temporal lobe.
J Clin Endocrinol Metab 1999;84:2795-801

Steckelbroeck S, Heidrich DD, Stoffel-Wagner B, Hans VH, Schramm J, Bidlingmaier F, Klingmuller D
Characterization of aromatase cytochrome P450 activity in the human temporal lobe.
J Clin Endocrinol Metab 84, 2795-801 (1999)

Steckelbroeck S, Watzka M, Reichelt R, Hans VH, Stoffel-Wagner B, Heidrich DD, Schramm J, Bidlingmaier F, Klingmuller D
Characterization of the 5alpha-reductase-3alpha-hydroxysteroid dehydrogenase complex in the human brain.
J Clin Endocrinol Metab 2001;86:1324-31

Steckelbroeck S, Watzka M, Reichelt R, Hans VH, Stoffel-Wagner B, Heidrich DD, Schramm J, Bidlingmaier F, Klingmuller D
Characterization of the 5alpha-reductase-3alpha-hydroxysteroid dehydrogenase complex in the human brain.
J Clin Endocrinol Metab, 1324-1331 (2001)

Steckelbroeck S, Watzka M, Stoffel-Wagner B, Hans VH, Redel L, Clusmann H, Elger CE, Bidlingmaier F , Klingmuller D
Expression of the 17beta-hydroxysteroid dehydrogenase type 5 mRNA in the human brain.
Mol Cell Endocrinol, 165-168 (2001)

Steckelbroeck S, Watzka M, Stoffel-Wagner B, Hans VH, Redel L, Clusmann H, Elger CE, Bidlingmaier F, Klingmuller D
Expression of the 17beta-hydroxysteroid dehydrogenase type 5 mRNA in the human brain.
Mol Cell Endocrinol 2001;171:165-8

Stoffel-Wagner B, Beyenburg S, Watzka M, Blümcke I, Bauer J, Schramm J, Bidlingmaier F, Elger CE
Expression of 5alpha-reductase and 3alpha-hydroxisteroid oxidoreductase in the hippocampus of patients with chronic temporal lobe epilepsy.
Epilepsia 41, 140-147 (2000)

Sukosd F, Digon B, Fischer J, Pietsch T, Kovacs G
Allelic loss at 10q23.3 but lack of mutation of PTEN/MMAC1 in chromophobe renal cell carcinoma.
Cancer Genet Cytogenet 128, 161-3 (2001)

Suslov ON, Kukekov VG, Laywell ED, Scheffler B, Steindler DA
RT-PCR amplification of mRNA from single brain neurospheres.
J Neurosci Met 96, 57-61 (2000)

Tasci S, Ewig S, Schafer H, Blümcke I, Leonhardt P, Gillissen A
Pulmonary aspergillosis in patients without pre-existing pulmonary disease after brain edema prevention with dexamethasone.
Pneumologie, 53, 213-215 (1999)

Thal DR, Barduzal S, Franz K, Herrmann G, Bode F, Lambrecht E, Schlote W
Giant cell arteritis in a 19-year-old woman associated with vertebral artery aneurysm and subarachnoid hemorrhage.
Clin. Neuropathol. (2001) 20: 80-86.

Thal DR, Barduzal S, Franz K, Herrmann G, Bode F, Lambrecht, E Schlote W
Giant cell arteritis in a 19-year-old woman associated with vertebral artery aneurysm and subarachnoid hemorrhage.
Clin Neuropathol 20, 80-86 (2001)

Thal DR, Härtig W, Schober R
Diffuse plaques in the molecular layer show intracellular 8-17-immunoreactive deposits in subpial astrocytes.
Clin. Neuropathol., 18 (1999) 226-231

Thal DR, Holzer M, Rüb U, Waldmann G, Günzel S, Zedlick D, Schober R
Alzheimer-related tau-pathology in the perforant path target zone and in the hippocampal stratum oriens and radiatum correlates with onset and degree of dementia.
Exp. Neurol. 163 (2000) 98-110

Thal DR, Rüb U, Schultz C, Sassin I, Ghebremedhin E, Del Tredici K, Braak E, Braak H
Sequence of A-protein deposition in the human medial temporal lobe.
J. Neuropathol. Exp. Neurol. 59 (2000) 733-748

Thal DR, Sassin I, Schultz C, Haass C, Braak E, Braak H
Fleecy amyloid deposits in the internal layers of the human entorhinal cortex are comprised of N-terminal truncated fragments of A-?.
J. Neuropathol. Exp. Neurol., 58 (1999) 210-216

Thal DR, Schultz C, Dehghani F, Yamaguchi H, Braak H, Braak E
A?-containing astrocytes are located preferentially near N-terminal truncated A-deposits in the human entorhinal cortex.
Acta Neuropathol. 100 (2000) 608-617

Timmermann B, Kortmann RD, Kühl J, Meisner C, Slavc I, Pietsch T, Bamberg M
Combined postoperative irradiation and chemotherapy for anaplastic ependymomas in childhood: results of the German prospective trials HIT 88/89 and HIT 91.
Int J Radiat Oncol Biol Phys 46, 287-295 (2000)

Uggowitzer MM, Kugler C, Groell R, Lindbichler F, Radner H, Sutter B, Ranner G
Drop metastases in a patient with a chondroid chordoma of the clivus.
Neuroradiology 41, 504-07 (1999)

Valter MM, Hügel A, Wiestler OD, Pietsch T, Wernert N
Ets-1 transcription factor is induced during neoangiogenesis in human gliomas and is related to Flt-1/VEGFR-1 expression.
Cancer Res. 59, 5608 -14 (1999)

Valter MM, Wiestler OD, Pietsch T
Differential control of VEGF synthesis and secretion in glioma cells by IL-1 and EGF.
Int. J. Dev. Neurosci. 17, 565-577 (1999)

Vince GH, Herbold C, Klein R, Kuh J, Pietsch T, Franz S, Roosen K, Tonn JC
Medulloblastoma displays distinct regional matrix metalloprotease expression.
J Neurooncol 53, 99-106 (2001)

Vince GH, Wagner S, Pietsch T, Klein R, Goldbrunner RH, Roosen K, Tonn JC
Heterogeneous regional expression patterns of matrix metalloproteinases in human malignant gliomas.
Int. J. Dev. Neurosci. 17, 437-445 (1999)

von Deimling A, Fimmers R, Schmidt MC, Bender B, Fassbender F, Nagel J, Jahnke R, Kaskel P, Duerr EM, Koopmann J, Maintz D, Steinbeck S, Wick W, Platten M, Müller DJ, Przkora R, Waha A, Blümcke B, Wellenreuther R, Meyer-Puttlitz B, Schmidt O, Mollenhauer J, Poustka A, Stangl AP, Lenartz D, von Ammon K, Henson JW, Schramm J, Louis DN, Wiestler OD
Comprehensive allelotype and genetic analysis of 466 human nervous system tumors.
J Neuropathol Exp Neurol 59, 544-558 (2000)

Von Schweinitz D, Faundez A, Teichmann B, Birnbaum T, Koch A, Hecker H, Glüer S, Pietsch T
Liver regeneration and tumor growth - the role of hepatocyte growth factor - scatter factor in childhood hepatoblastoma.
Int J Cancer 85, 151-159 (2000)

Walch E, Schmitt M, Brenner R, Emons D, Dame C, Pontz B, Wiestler OD, Bartmann P
Yunis-Varon syndrome: evidence of a lysosomal storage disease.
Am J Med Genet 95, 157-60 (2000)

Watzka M, Beyenburg S, Blümcke I, Elger CE, Bidlingmaier F, Stoffel-Wagner B
Expression of mineralocorticoid and glucocorticoid receptor mRNA in the human hippocampus.
Neurosci Lett 290, 121-124 (2000)

Weber RG, Pietsch T, von Schweinitz D, Lichter P
Characterization of chromosomal imbalances in hepatoblastomas: a role for gains on 8q and 20 as predictors of outcome.
Am J Pathol 157, 571-578 (2000)

Weggen S, Bayer TA, von Deimling A, Reifenberger G, von Schweinitz D, Wiestler OD, Pietsch T
Low frequency of SV40 JC and BK polyomavirus sequences in human medulloblastomas, meningiomas and ependymomas.
Brain Pathol 10, 85-92 (2000)

Weggen S, Preuss U, Pietsch T, Hilger N, Klawitz I, Scheidtmann KH, Wiestler OD, Bayer TA
Identification of amplified genes from SV40 large T antigen-induced rat PNET cell lines by subtractive cDNA analysis and radiation hybrid mapping.
Oncogene 20, 2023-31 (2001)

Weggen S, Tienari PJ, Beyreuther K, Bayer TA
Retroviral shuttle vectors in Alzheimer´s disease research.
Neurol Psychiatr Brain 6, 213-18 (1999)

Weil S, Reifenberger G, Dudel C, Yousry TA, Noachtar S
Cerebroretinal vasculopathy mimicking a brain tumor.
Neurology 53, 629-631 (1999)

Wiestler O.D., Brüstle O
Forschung an embryonalen Stammzellen: Was versprechen sich die klinischen Neurowissenschaften davon?
Stammzellforschung und Therapeutisches Klonen. Oduncu / Schroth / Vossenkuhl (Hrsg.) Vandenhoeck & Ruprecht, Göttingen 2001 (2001)

Wiestler OD, Lopes BS, Green AJ, Vinters HV
Tuberous sclerosis complex and subependymal giant cell astrocytoma. In Pathology and genetics of tumors of the nervous system, WHO Classification of Tumours. 2nd Edition. Edited by P. Kleihues, W. Cavenee.
International Agency for Research on Cancer; Lyon, pp 227-230 (2000)

Wiestler OD, Lopes BS, Green AJ, Vinters HV
Tuberous sclerosis complex and subependymal giant cell astrocytoma. In Pathology and genetics of tumors of the nervous system, WHO Classification of Tumours. 2nd Edition. Edited by P. Kleihues, W. Cavenee.
International Agency for Research on Cancer; Lyon, pp 227-230 (2000)

Wiestler OD, Schiffer D
Subependymoma. In Pathology and genetics of tumors of the nervous system, WHO Classification of Tumours. 2nd Edition. Edited by P. Kleihues, W. Cavenee.
International Agency for Research on Cancer; Lyon, pp 80-81 (2000)

Wiestler OD, Schiffer D, Coons SW, Prayson RA, Rosenblum MK
Ependymoma. In Pathology and genetics of tumors of the nervous system, WHO Classification of Tumours. 2nd Edition. Edited by P. Kleihues, W. Cavenee.
International Agency for Research on Cancer; Lyon, pp 72-76 (2000)

Wiestler OD, Schiffer D, Coons SW, Prayson RA, Rosenblum MK
Anaplastic ependymoma. In Pathology and genetics of tumors of the nervous system, WHO Classification of Tumours. 2nd Edition. Edited by P. Kleihues, W. Cavenee.
International Agency for Research on Cancer; Lyon, pp 76-77 (2000)

Wiestler OD, Schiffer D, Coons SW, Prayson RA, Rosenblum MK
Myxopapillary ependymoma. In Pathology and genetics of tumors of the nervous system, WHO Classification of Tumours. 2nd Edition. Edited by P. Kleihues, W. Cavenee.
International Agency for Research on Cancer; Lyon, pp 78-79. (2000)

Windisch A, Reitinger A, Traxler H, Radner H, Neumayer C, Feigl W , Firbas W
Morphology and histochemistry of myogelosis.
Clin Anat 12, 266-71 (1999)

Wolff JEA, Moelenkamp G, Westphal S, Pietsch T, Gnekow A, Kortmann RD, Kuehl J
Oral trophaphamide and VP16 in pediatric patients with glioblastoma multiforme.
Cancer 89, 2131-37 (2000)

Yilmazer-Hanke DM, Wolf HK, Schramm J, Elger CE, Wiestler OD, Blümcke I
Subregional pathology of the amygdala complex and entorhinal region in surgical specimens from patients with pharmacoresistant temporal lobe epilepsy.
J Neuropathol Exp Neurol 59, 907-920 (2000)

Zentner J, Wolf HK, Helmstaedter C, Grunwald T, Aliashkevich AF, Wiestler OD, Elger CE, Schramm J
Clinical relevance of amygdala sclerosis in temporal lobe epilepsy.
J Neurosurg 91, 59-67 (1999)

Zhang SC, Wernig M, Duncan ID, Brüstle O, Thomson JA
In vitro differentiation of transplantatble neural precursors from human embryonic stem cells.
Nature Biotech 19:1129-1133 (2001)


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