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FORSCHUNGSBERICHT 1999-2001

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Klinik u. Poliklinik f.Anästhesiologie u. spezielle Intensivmedizin

Allgemeine Angaben:
Sigmund-Freud-Straße 25, 53105 Bonn
Telefon: 0228 / 287-4110
Fax: 0228 / 287-4115

Hauptamtliche Professoren:
Prof. Dr. Andreas Hoeft Direktor der Klinik für Anästhesiologie und Spezielle Intensivmedizin
Prof. Dr. Christian Putensen
Prof. Dr. Bernd Urban

Wissenschaftliches Personal:
Universitätsstellen
Dr. Mohammed Al Mafraji
Dr. Carsta Appfelstaedt
Dr. Susannne Aschenbrenner
Priv. Doz. Dr. Martin Barann
Dr. Georg Baumgarten
Dr. Elisabeth Behrens-Callsen
Dr. Daniel Berning
Dr. Malte Book
Martin Breil
Dr. Jörgen Bruhn
Dr. Johannes Busch
Dr. Jan Cornelssen
Henning Cuhls
Monju Cuhls
Alfred Dahmen
Dr. Dorothea Dörr
Dr. Lutz Eckermann
Dr. Richard Ellerkmann
Lutz Fehrle
Dr. Dirk Fingerhut
Priv. Doz. Dr. Matthias Fischer
Dr. Nicolas Fischer
Dr. Günter Fromm
Dr. Annette Gass
Dr. Savvas Giannaris
Dr. Ingo Gräff
Dr. Claudia Greive
Dr. Stefan Haupts
Dr. Ingo Heinze
Dr. Ulrich Heister
Dr. Peter Henn
Dr. Rudolf Hering
Dr. Kathrin Heuer
Dr. Markus Kaiser
Dr. Ludger Kaumanns
Nicholas Kiefer
Se-Chan Kim
Dr. Sven Klaschik
Dr. Michael Klein
Dr. Pascal Knüfermann
Dr. Hans-Henning Krep
Dr. Annette Lauschke
Dr. Lutz Lehmann
Dr. Heiko Lier
Petra Lilienweiß
Dr. Monika Mädrich
Professor Harri K. Murday
Professor Joachim Nadstawek
Dr. Claudia Neumann
Dr. Volker Pless
Dr. Gabriele Putensen-Himmer
Professor Kuno Rommelsheim
Dr. Heiko Röpcke
Dr. Karin Rose
Reinhard Rüschner
Dr. Jens-Christian Schewe
Dr. Rolf Scholer-Everts
Martin Scholz
Dr. Stefan Schröder
Dr. Andreas Schultze
Dr. Andreas Schwarzer
Dr. Ulrike Stamer
Priv. Doz. Dr. Frank Stüber
Mark Tanzberger
Dr. Christof Thees
Dr. Irmhild Thiemig-Frank
Dr. Dirk Varelmann
Dr. Andreas Viehöfer
Ralph Vorwerk
Dr. Stefan Wälde
Dr. Hans-Christian Wartenberg
Dr. Stefan Weber
Dr. Ingobert Wenningmann
Dr. Silke Wetegrove
Dr. Götz Wietasch
Dr. Stefan Wirz
Dr. Maria Wittmann
Dr. Hermann Wrigge
Jörg Zinserling

Forschungsschwerpunkte:
Antiinflammatorische Therapiestrategien bei systemischen Entzündungen

Anwendung Chaos-theoretischer Konzepte zur Interpretation Anästhetika-bedingter EEG-Veränderungen

EEG gestützte Steuerung der Narkosetiefe v incl. Target Controlled Infusion - Dosierungskonzepte für intra-venöse Anästhetika

Einfluß verschiedener Transkriptionsfaktoren auf die Zytokinexpression

Elektrophysiologischen Monitoring der spinalen und cortikalen Funktionen im Rahmen von Allgemeinanästhesien

Evaluierung perioperativer Risikofaktoren unter besonderer Berücksichtigung geriatrischer Patienten

Expressionsmuster pro- und antiinflammatorischer Proteine

Funktion von endogenen Cortisolantagonisten bei systemischen Entzündungsreaktionen

Hitzeschockproteine als Schutzmechanismen bei zellulären Streßmechanismen

Pharmakokinetik und -dynamik von Opiaten bei Erwachsenen und Kindern unter besonderer Berücksichtigung der Opiat-induzierten Atemdepression

SEP-Monitoring und EEG zur Überwachung der zerebralen Funktion in der zerebralen Aneurysmachirurgie und Carotischirurgie

SEP-Monitoring unter totaler intravenöser Anästhesie

SEP-Monitoring zur Quantifizierung von rückenmarksnahen und peripheren Leitungsblockaden

Tierexperimentelle und klinische Untersuchungen zum Einfluß von intravenösen und volatilen Anästhetika, Benzodiazepinen und Opiaten auf motorisch evozierte und somato-senosorisch evozierte Potentiale

Untersuchung der Interaktion von volatilen Anästhetika, Stickoxidul, Propofol und Opiaten

Untersuchung des Zusammenhangs der Anästhetikawirkung auf cortikale und kardiovaskuläre Funktionen

Cannabinoide hemmen 5-HT3 Rezeptoren stereoselektiv und bei nanomolaren Konzentrationen.
(Barann)

Einfluss der Lipophilie strukturell ähnlicher Anästhetika (Barbiturate) auf die Wirkung am 5-HT3 Rezeptor
(Barann)

Propofol hemmt den 5-HT3 Rezeptor mit ähnlicher Kinetik wie dieser durch 5-HT desensibilisiert wird, und ist möglicherweise deshalb anti-emetisch
(Barann)

Morphin inhibiert 5-HT3 Rezeptoren bei analgetischen Konzentrationen minimal, kann also Emesis, moduliert über 5-HT3 Rezeptoren nicht an dieser Stelle inhibieren
(Barann, Wittmann)

Bedeutung inflammatorischer Mediatoren bei Patienten mit neuropathischen Schmerzen
(Baumgarten , Knüfermann)

Angeborene Immunabwehr und Organfunktion
(Baumgarten , Knüfermann, Kim)

Risikoevaluation der septischen Kardiomyopathie bei Intensivpatientenzifischen
(Baumgarten , Knüfermann, Kim)

Genetische Diagnostik bei Sepsis-Patienten, Risikoevaluation bei Intensivpatienten
(Book)

Molekularbiologische Untersuchung zur Genexpression pro- und antiinflammatorisch wirkender Proteine in Abhängigkeit von genomischen Polymorphismen
(Book)

Molekulare Grundlagen der Sepsis
(Book)

Molekulargenetische Untersuchungen zur Risikoabschätzung von Patienten mit systemischen Entzündungsreaktionen
(Book)

Zytokin-Diagnostik in der Intensivmedizin
(Book)

Charakterisierung der akustisch evozierten Signale mittlerer Latenz (MLAEP)
(Ellerkmann, Wenningmann, Urban)

Charakterisierung eines neuartigen Monitors zur Messung akustisch evozierter Potentiale. Vergleich der evozierten Potentiale an Patienten mittels Oberflächenelektroden, Subdural-Elektroden und Tiefenelektroden
(Ellerkmann, Wenningmann, Urban)

Blutvolumen und Lungenwasser Messungen: Auswirkung von Dexamethason
(Giannaris)

Blutvolumen und Lungenwasser Messungen: Beeinflussung durch Narkoseeinleitung
(Giannaris)

Energetik und Ökonomie der myokardialen Pumpfunktion
(Hoeft)

Leberdurchblutungsmessung mittels konstanter Indikator Infusion (ICG)
(Kiefer)

Angeborene Imunabwehr (innate immunity) und Toll-Like-Rezeptoren
(Knüfermann, Baumgarten , Kim)

Veränderungen der Erholung von der Inaktivierung humaner Natriumkanäle bei Epilepsie als mögliche Erklärung für Therapieresistenz
(Remy)

Blutvolumen und Lungenwasser Messungen: Änderungen des Volumenstatus in der Sepsis
(Scholz)

Hepatische Hämodynamik mittels Doppelindikator-Verdünnungstechnik.
(Scholz)

Nichtinvasive Herzzeitvolumen - Bestimmung
(Scholz)

Nicht-invasive Indikatorquantifizierung mittels Pulsphotometrie
(Scholz)

Nichtinvasive Leberfunktionsprüfung mittels Pulsphotometrie
(Scholz)

Genaue Charakterisierung der Kinetik von Muskelrelaxantien an ACh Rezeptoren
(Wenningmann)

Herzzeitvolumen (HZV) - Messung bei pädiatrischen Patienten
(Wietasch)

Herzzeitvolumen- Messung bei intrakardialen Shunts
(Wietasch)

Pulmonale versus aortale Thermodilution
(Wietasch)

Validierung berechneter Blutvolumina: Totales Blutvolumen (TBV), Intratthorakales Blutvolumen (ITBV) sowie Extravaskuläres Lungenwasser (EVLW)
(Wietasch)

Vergleichende HZV-Bestimmungen am Flussmodell
(Wietasch)

HZV - Messung : Validierungen kontinuierlicher Verfahren
(Witasch, Scholz)

Besondere Forschungsförderung:
Monitoring der Unterdrückung motorischer Reaktionen auf Schmerzreize während Allgemeinanästhesien mittels spinaler Reizantworten (H-Reflex und F-Wellen) und Vergleich mit zerebralen Anästhetikaeffekten auf EEG und akustisch evozierte Potentiale
(Rehberg, Urban, DFG Re 1534 / 2-1)

Veröffentlichungen:

Barann M, Dilger JP, Bonisch H, Gothert M, Dybek A, Urban BW
of 5-HT(3) receptors by propofol: equilibrium and kinetic measurements
Inhibition. Neuropharmacology 2000; 39(6):1064-1074

Barann M, Friederich P, Retzmann K, Dybek A, Urban BW
Loss of propofol during in vitro experiments
Anesthesiology 2000; 93(1):310-311

Barann M, Gothert M, Bruss M, Bonisch H
Inhibition by steroids of [14C]-guanidinium flux through the voltage- gated sodium channel and the cation channel of the 5-HT3 receptor of N1E-115 neuroblastoma cells
Naunyn Schmiedebergs Arch Pharmacol 1999; 360(3):234-241.

Barann M, Meder W, Dorner Z, Bruss M, Bonisch H, Gothert M et al.
Recombinant human 5-HT3A receptors in outside-out patches of HEK 293 cells: basic properties and barbiturate effects
Naunyn Schmiedebergs Arch Pharmacol 2000; 362(3):255-265.

Bartsch AC, Fischer M
Säuglingsreanimation-Ausdauer lohnt sich
ÄP Pädiatrie 1999; 10:18.

Bartsch AC, Foedisch M, Fischer M
Unterkühlung als Lebensretter
ÄP Pädiatrie 1999; 1:24.

Baumgarten G, Knuefermann P, Nozaki N, Sivasubramanian N, Mann DL, Vallejo JG
In vivo expression of proinflammatory mediators in the adult heart after endotoxin administration: the role of toll-like receptor-4
J Infect Dis 2001; 183(11):1617-1624

Bluemcke I, Schewe JC, Normann S, Bruestle O, Schramm J, Elger CE et al
. Increase of nestin-immunoreactive neural precursor cells in the dentate gyrus of pediatric patients with early-onset temporal lobe epilepsy
Hippocampus 2001; 11:311-321

Bluemcke I, Zuschratter W, Schewe JC, Suter B, Lie AA, Riederer BM et al.
Cellular pathology of hilar neurons in Ammon's horn sclerosis
J Comp Neurol 2001; 414:437-453.

Bouillon T, Kietzmann D, Port R, Meineke I, Hoeft A
Population pharmacokinetics of piritramide in surgical patients
Anesthesiology 1999; 90(1):7-15

Bouillon T, Schmidt C, Garstka G, Heimbach D, Stafforst D, Schwilden H et al
Pharmacokinetic-pharmacodynamic modeling of the respiratory depressant effect of alfentanil
Anesthesiology 1999; 91(1):144-155

Bouillon T, Shafer SL
Hot air or full steam ahead? An empirical pharmacokinetic model of potent inhalational agents
Br J Anaesth 2000; 84(4):429-431

Brauer A, Wrigge H, Kersten J, Rathgeber J, Weyland W, Burchardi H.
Severe accidental hypothermia: rewarming strategy using a veno-venous bypass system and a convective air warmer
Intensive Care Med 1999; 25(5):520-523.

Brinker G, Bock C, Busch E, Krep H, Hossmann KA, Hoehn-Berlage M.
Simultaneous recording of evoked potentials and T2*-weighted MR images during somatosensory stimulation of rat
Magn Reson Med 1999; 41(3):469-473.

Bruemmer-Smith S, Stuber F, Schroeder S
Protective functions of intracellular heat-shock protein (HSP) 70-expression in patients with severe sepsis.
Intensive Care Med 2001; 27(12):1835-1841

Bruess M, Barann M, Hyaer-Zillgen MH, Euker M, Goethert M, Urban BW
Modified 5-TH3A receptor function by co-expression of alternatively splieed human 5-HT3A receptor isoforms
Naunyn Schmiedebergs Arch Pharmacol 2000; 362:392-401

Bruhn J, Bouillon T, Shafer SL
Bispectral index (BIS) and burst suppression: revealing a part of the BIS algorithm
J Clin Monitor Comp 2001; 16:593-596.

Bruhn J, Bouillon TW, Shafer SL
Electromyographic activity falsely elevates the bispectral index
Anesthesiology 2000; 92(5):1485-1487.

Bruhn J, Lehmann LE, Ropcke H, Bouillon TW, Hoeft A.
Shannon entropy applied to the measurement of the electroencephalographic effects of desflurane
Anesthesiology 2001; 95(1):30-35

Bruhn J, Ropcke H, Hoeft A
Approximate entropy as an electroencephalographic measure of anesthetic drug effect during desflurane anesthesia
Anesthesiology 2000; 92(3):715-726.

Bruhn J, Bouillon TW, Shafer SL
Onset of propofol-induced burst suppression may be correctly detected as deepening of anaesthesia by approximate entropy but not by bispectral index
Br J Anaesth 2001; 87(3):505-507

Buhre W, Weyland A, Schorn B, Scholz M, Kazmaier S, Hoeft A et al
Changes in central venous pressure and pulmonary capillary wedge pressure do not indicate changes in right and left heart volume in patients undergoing coronary artery bypass surgery
Eur J Anaesthesiol 1999; 16(1):11-17.

Ellerkmann RK, Riazanski V, Elger CE, Urban BW, Beck H
Slow recovery from inactivation regulates the availability of voltage-dependent Na(+) channels in hippocampal granule cells, hilar neurons and basket cells
J Physiol 2001; 532(Pt 2):385-397

Fang XM, Schroder S, Hoeft A, Stuber F.
Comparison of two polymorphisms of the interleukin-1 gene family: interleukin-1 receptor antagonist polymorphism contributes to susceptibility to severe sepsis
Crit Care Med 1999; 27(7):1330-1334.

Fischer A, Pallauf J, Gohil K, Weber SU, Packer L, Rimbach G
Effect of selenium and vitamin E deficiency on differential gene expression in rat liver
Biochem Biophys Res Commun 2001; 285(2):470-475

Fischer M, Thees C, Bartsch AC.
Schädel-Hirn-Trauma - Koma jede Minute zählt
ÄP Pädiatrie 1999; 3:22.

Fischer M, Krafft T.
Vergleich europäisher Rettungsdienst-Systeme
Notarzt 2001; 1:55-56

Friederich P, Benzenberg D, Trellakis S, Urban BW
Interaction of volatile anesthetics with human Kv channels in relation to clinical concentrations
Anesthesiology 2001; 95(4):954-958.

Friederich P, Benzenberg D, Urban BW
Ketamine and propofol differentially inhibit human neuronal K(+) channels
Eur J Anaesthesiol 2001; 18(3):177-183

Friederich P, Dybek A, Urban BW
Stereospecific interaction of ketamine with nicotinic acetylcholine receptors in human sympathetic ganglion-like SH-SY5Y cells
Anesthesiology 2000; 93(3):818-824

Friederich P, Putensen C, Stuber F
Prothrombin gene G20210A mutation and elevated anticardiolipin antibodies in a patient with combined portal-mesenteric vein thrombosis
Intensive Care Med 2000; 26(10):1571-1574

Friederich P, Putensen C, Stuber F
Prothrombin gene G20210A mutation and elevated anticardiolipin antibodies in a patient with combined portal-mesenteric vein thrombosis
Intensive Care Med 2000; 26(10):1571-1574

Friederich P, Putensen C, Stuber F
Prothrombin gene G20210A mutation and elevated anticardiolipin antibodies in a patient with combined portal-mesenteric vein thrombosis
Intensive Care Med 2000; 26(10):1571-1574

Friederich P, Putensen C, Stuber F
Prothrombin gene G20210A mutation and elevated anticardiolipin antibodies in a patient with combined portal-mesenteric vein thrombosis
Intensive Care Med 2000; 26(10):1571-1574

Friederich P, Urban BW
Interaction of intravenous anesthetics with human neuronal potassium currents in relation to clinical concentrations. Anesthesiology
1999; 91(6):1853-1860.

Friederich P, Trellakis S, Urban BW
Epileptic seizures from etomidate? The human Kv1.1 potassium channel in humans
Intensivmed Notfallmed Schmerzther 2001; 36(2):100-104

Hering R, Wrigge H, Vorwerk R, Brensing KA, Schroder S, Zinserling J et al.
The effects of prone positioning on intraabdominal pressure and cardiovascular and renal function in patients with acute lung injury.
Anesth Analg 2001; 92(5):1226-1231

Herlitz J, Bahr J, Fischer M, Kuisma M, Lexow K, Thorgeirsson G.
Resuscitation in Europe: a tale of five European regions. Resuscitation
1999; 41(2):121-131

Hoeft A, Wietasch G
Measurement of cerebral blood flow at the bedsise
Anesthesiology 2000; 93:1555-1556

Hossmann KA, Oschlies U, Schwindt W, Krep H.
Electron microscopic investigation of rat brain after brief cardiac arrest
Acta Neuropathol (Berl) 2001; 101(2):101-113.

Hubacek JA, Stuber F, Frohlich D, Book M, Wetegrove S, Ritter M et al.
Gene variants of the bactericidal/permeability increasing protein and lipopolysaccharide binding protein in sepsis patients: gender-specific genetic predisposition to sepsis
Crit Care Med 2001; 29(3):557-561

Kalra D, Baumgarten G, Dibbs Z, Seta Y, Sivasubramanian N, Mann DL.
Nitric oxide provokes tumor necrosis factor-alpha expression in adult feline myocardium through a cGMP-dependent pathway.
Circulation 2000; 102(11):1302-1307

Keller E, Wietasch G, Ringleb P, Scholz M, Schwarz S, Stingele R et al.
Bedside monitoring of cerebral blood flow in patients with acute hemispheric stroke.
Crit Care Med 2000; 28(2):511-516.

Krep H, Brinker G, Pillekamp F, Hossmann KA
. Treatment with an endothelin type A receptor-antagonist after cardiac arrest and resuscitation improves cerebral hemodynamic and functional recovery in rats
Crit Care Med 2000; 28(8):2866-2872

Krep H, Brinker G, Schwindt W, Hossmann KA
Endothelin type A-antagonist improves long-term neurological recovery after cardiac arrest in rats.
Crit Care Med 2000; 28(8):2873-2880

Kuhlen R, Putensen C.
Maintaining spontaneous breathing efforts during mechanical ventilatory support
Intensive Care Med 1999; 25(11):1203-1205.

Kurrelmeyer KM, Michael LH, Baumgarten G, Taffet GE, Peschon JJ, Sivasubramanian N et al
Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction
Proc Natl Acad Sci U S A 2000; 97(10):5456-5461

Lehmann LE, Novender U, Schroeder S, Pietsch T, von Spiegel T, Putensen C et al.
Plasma levels of macrophage migration inhibitory factor are elevated in patients with severe sepsis.
Intensive Care Med 2001; 27(8):1412-1415

Loer SA, Wietasch JK, Scheeren TW
Does bronchial thermodilution allow estimation of cardiac output ?
Intensive Care Med 1999; 25(2):211-215.

Majetschak M, Flohe S, Obertacke U, Schroder J, Staubach K, Nast-Kolb D et al
Relation of a TNF gene polymorphism to severe sepsis in trauma patients
Ann Surg 1999; 230(2):207-214.

Mielck F, Wietasch G, Weyland A, Buhre W, Meier-Theile C, Hoeft A et al
Reliability of cerebral blood flow measurements by transcerebral double-indicator dilution technique.
Eur J Anaesthesiol 2001; 18(10):653-661

Nossuli TO, Frangogiannis NG, Knuefermann P, Lakshminarayanan V, Dewald O, Evans AJ et al
Brief murine myocardial I/R induces chemokines in a TNF-alpha-independent manner: role of oxygen radicals
Am J Physiol Heart Circ Physiol 2001; 281(6):H2549-H2558.

Nossuli TO, Lakshminarayanan V, Baumgarten G, Taffet GE, Ballantyne CM, Michael LH et al.
chronic mouse model of myocardial ischemia-reperfusion: essential in cytokine studies.
Am J Physiol Heart Circ Physiol 2000; 278(4):H1049-H1055

Packer L, Weber SU, Rimbach G
Molecular aspects of alpha-tocotrienol antioxidant action and cell signalling
J Nutr 2001; 131(2):369S-373S

Picker O, Wietasch G, Scheeren TW, Arndt JO
Determination of total blood volume by indicator dilution: a comparison of mean transit time and mass conservation principle
Intensive Care Med 2001; 27(4):767-774

Pollak PT, Bouillon T, Shafer SL.
Population pharmacokinetics of long-term oral amiodarone therapy
Clin Pharmacol Ther 2000; 67(6):642-652.

Putensen C, Mutz NJ, Putensen-Himmer G, Zinserling J.
Spontaneous breathing during ventilatory support improves ventilation-perfusion distributions in patients with acute respiratory distress syndrome.
Am J Respir Crit Care Med 1999; 159(4 Pt 1):1241-1248.

Putensen C, Wrigge H.
Ventilator-associated systemic inflammation in acute lung injury
Intensive Care Med 2000; 26(10):1411-1413.

Putensen C, Zech S, Wrigge H, Zinserling J, Stuber F, von Spiegel T et al
Long-term effects of spontaneous breathing during ventilatory support in patients with acute lung injury.
Am J Respir Crit Care Med 2001; 164(1):43-49.

Reckziegel G, Beck H, Schramm J, Urban BW, Elger CE.
Carbamazepine effects on Na+ currents in human dentate granule cells from epileptogenic tissue.
Epilepsia 1999; 40(4):401-407

Rehberg B, Duch DS
Suppression of central nervous system sodium channels by propofol
Anesthesiology 1999; 91(2):512-520

Rehberg B, Wittmann M, Urban BW
. Sodium channels (from rat, mouse, and man) in neuroblastoma cells and different expression systems have similar sensitivities to pentobarbital.
Neurosci Lett 1999; 264(1-3):81-84.

Rehberg B, Bouillon T, Zinserling J, Hoeft A
Comparative pharmacodynamic modeling of the electroencephalography-slowing effect of isoflurane, sevoflurane, and desflurane
Anesthesiology 1999; 91(2)397-405

Rimbach G, Gohil K, Matsugo S, Moini H, Saliou C, Virgili F et al.
Induction of glutathione synthesis in human keratinocytes by Ginkgo biloba extract (EGb761)
Biofactors 2001; 15(1):39-52.

Rommelscheim K.
Antibiotische Therapie bei schwerkranken Patienten
Chemotherapie Journal 1999; 8:33-37

Ropcke H, Bruhn J, Bouillon T, Hoeft A. [
Optimierung der Erhaltungskonzentrationen von Inhalationsanästhetika und Opiaten - Eine pharmako-ökonomische Modellrechnung
Anaesth Intensivmed 2001; 42:922-928.

Ropcke H, Konen-Bergmann M, Cuhls M, Bouillon T, Hoeft A
Propofol and remifentanil pharmacodynamic interaction during orthopedic surgical procedures as measured by effects on bispectral index
J Clin Anesth 2001; 13(3):198-207

Ropcke H, Lier H, Hoeft A, Schwilden H.
Isoflurane, nitrous oxide, and fentanyl pharmacodynamic interactions in surgical patients as measured by effects on median power frequency.
J Clin Anesth 1999; 11(7):555-562.

Ropcke H, Rehberg B, Koenen-Bergmann M, Bouillon T, Bruhn J, Hoeft
A. Surgical stimulation shifts EEG concentration-response relationship of desflurane.
Anesthesiology 2001; 94(3):390-399.

Ropcke H, Wartenberg HC
Inducing spontaneous respiration at the end of surgery
Anasthesiol Intensivmed Notfallmed Schmerzther 2000; 35(7):459-460

Ropcke H, Wirz S, Bouillon T, Bruhn J, Hoeft A.
Pharmacodynamic interaction of nitrous oxide with sevoflurane, desflurane, isoflurane and enflurane in surgical patients: measurements by effects on EEG median power frequency.
Eur J Anaesthesiol 2001; 18(7):440-449.

Schmidt S, Hertfelder HJ, von Spiegel T, Hering R, Harzheim M, Lassmann H et al.
capillary leak syndrome after a single administration of interferon beta-1b
Lethal. Neurology 1999; 53(1):220-222.

Schneider MC, Wulf H, Biermann E, Stamer U, Mitterschiffthaler G, Juen E et al
Clearing the epidural catheter in the delivery room
Anaesthesist 2000; 49(4):324-327.

Schroder J, Kahlke V, Book M, Stuber F.
Gender differences in sepsis: genetically determined?
Shock 2000; 14(3):307-310.

Schroder J, Staubach KH, Zabel P, Stuber F, Kremer B.
Procalcitonin as a marker of severity in septic shock.
Langenbecks Arch Surg 1999; 384(1):33-38.

Schroeder S, Bischoff J, Lehmann LE, Hering R, von Spiegel T, Putensen C et al
Endotoxin inhibits heat shock protein 70 (HSP70) expression in peripheral blood mononuclear cells of patients with severe sepsis.
Intensive Care Med 1999; 25(1):52-57.

Schroeder S, Hoeft A, Stuber F.
Die Schutzfunktion der intrazellulären Hitze-Schock-Protein 70-Expression bei Patienten mit schwerer Sepsis
Anaesth Intensivmed 2001; 42:296-302

Schroeder S, Hubbert T, Czerwinski M, Papenfuss K, Hering R.
Notfallmedizinische Versorgung des scheren Tauchunfalls
Rettungsdienst 2001; 24:58-63.

Schroeder S, Lindemann C, Decker D, Klaschik S, Hering R, Putensen C et al.
susceptibility to apoptosis in circulating lymphocytes of critically ill patients Increased
Langenbecks Arch Surg 2001; 386(1):42-46.

Schroeder S, Lindemann C, Hoeft A, Putensen C, Decker D, von Ruecker AA et al
Impaired inducibility of heat shock protein 70 in peripheral blood lymphocytes of patients with severe sepsis.
Crit Care Med 1999; 27(6):1080-1084.

Schroeder S, Reck M, Hoeft A, Stuber F.
Analysis of two human leukocyte antigen-linked polymorphic heat shock protein 70 genes in patients with severe sepsis
Crit Care Med 1999; 27(7):1265-1270.

Schroeder S, Reck M, Lehmann LE, Book M, Hoeft A, Stuber F
The Pstl polymorphism of the endotoxin-inducible heat-shock protein 70-2 gene does not affect messenger RNA level in human whole-blood cultures.
Intensive Care Med 2000; 26(8):1139-1143

Schroeder S, Springer W, Hashemian H, Wichers M, Klingmuller D, Putensen C et al.
Somatotropic axis dysfunction in critically ill patients: altered response to growth hormone-releasing hormone
Intensivmed 2001; 38:187-192

Schroeder S, Wichers M, Klingmuller D, Hofer M, Lehmann LE, von Spiegel T et al.
The hypothalamic-pituitary-adrenal axis of patients with severe sepsis: altered response to corticotropin-releasing hormone
Crit Care Med 2001; 29(2):310-316

Stamer U, Grond S, Schneck H, Wulf H.
Surveys of the use of regional anaesthesia in obstetrics.
Current Opinion in Anesthesiology 1999; 12:565-571.

Stamer U, Henn P, Stamper U
Is the Wurzburger pain drip an alternative to i.v. PCA?": contra
Anasthesiol Intensivmed Notfallmed Schmerzther 2000; 35(1):30-32.

Stamer U, Wulf H
Complications of obstetric anaesthesia.
Curr Opin Anaesth 2001; 14:317-322.

Stamer U, Wulf H, Hoeft A, Biermann E.
Geburtshilfliche Epiduralanästhesie: Aufklärung und Dokumentation
Anaesthesiologie und Intensivmedizin 2000; 41:104-112.

Stamer U, Wulf H.
Obstetric anaesthesia in Germany.
Acta Anaesthesiol Scand 1999; 43(362):364.

Stamer U.
Anesthesia for Cesarean section in Germany in 1997
Anasthesiol Intensivmed Notfallmed Schmerzther 1999; 34(2):115-116.

Stamer UM, Buderus S, Wetegrove S, Lentze MJ, Stuber F
Prolonged awakening and pulmonary edema after general anesthesia and naphazoline application in an infant
Anesth Analg 2001; 93(5):1162-4, table

Stamer UM, Grond S, Maier C
Responders and non-responders to post-operative pain treatment: the loading dose predicts analgesic needs.
Eur J Anaesthesiol 1999; 16(2):103-110.

Stamer UM, Stuber F.
Analgesic efficacy of tramadol if coadministered with ondansetron
Anesth Analg 2001; 93(6):1626

Stamer U, Messerschmidt A, Wulf H, Hoeft A
Practice of epidural analgesia for labour pain: a German survey.
Eur J Anaesthesiol 1999; 16(5):308-314.

Stamer UM, Messerschmidt A, Wulf H, Hoeft A
Equipment for the difficult airway in obstetric units in Germany
J Clin Anesth 2000; 12(2):151-156.

Stuber F, Book M, Wetegrove S, Schroeder S
The role of genomic polymorphisms in sepsis.
Advances in Sepsis 2001; 1:58-64.

Stuber F, Hoeft A
Critical illness and the inflammatory response.
Best Pract Res Cl Anaesth 2001; 15:289-299.

Stuber F, Schroeder S.
Sepsis: The role of genomic polymorphisms
NVIC Monitor 2001; 5:19-23.

Stuber F.
Effects of genomic polymorphisms on the course of sepsis: is there a concept for gene therapy?
J. Am Soc Nephrol 2001; 12 Suppl 17:S60-S64

Thees C, Frenkel C, Hoeft A
Remifentanil in der Neuroanästhesie - Eine multizentrische Anwendungsbeobachtung
Anaesth Intensivmed 2001; 42:205-211.

Thees C, Scheufler KM, Nadstawek J, Pechstein U, Hanisch M, Juntke R et al
Influence of fentanyl, alfentanil, and sufentanil on motor evoked potentials.
J Neurosurg Anesthesiol 1999; 11(2):112-118.

Tiemann K, Schlosser T, Pohl C, Bimmel D, Wietasch G, Hoeft A et al.
Are microbubbles free flowing tracers through the Myocardium? Comparison of indicator-dilution curves obtained from dye dilution and echo contrast using harmonic power Doppler imaging
Echocardiography 2000; 17(1):17-27.

Tonner PH, Urban BW.
Unincorporated Channel Meeting (UCM)--basic research on mechanisms of anesthesia
Anasthesiol Intensivmed Notfallmed Schmerzther 2000; 35(9):592-593

Urban BW, Barann M, Friederich P, Rehberg B, Wartenberg HC, Wenningmann I
Comparing anaesthetic actions on transmitter-activated and voltage-activated ion channels
PAM 2000; 6:237-244

Valacchi G, Rimbach G, Saliou C, Weber SU, Packer L.
Effect of benzoyl peroxide on antioxidant status, NF-kappaB activity and interleukin-1alpha gene expression in human keratinocytes
Toxicology 2001; 165(2-3):225-234.

Vallejo JG, Knuefermann P, Mann DL, Sivasubramanian N.
Group B Streptococcus induces TNF-alpha gene expression and activation of the transcription factors NF-kappa B and activator protein-1 in human cord blood monocytes
J Immunol 2000; 165(1):419-425

von Spiegel T
Monitoring des kardiovaskulären Systems. Intensiv- und Notfallbehandlung
Intensiv- und Notfallbehandlung 1999; 24:25-32.

von Spiegel T, Giannaris S, Wrigge H, Schorn B, Hoeft A.
Effects of dexamethasone on extravascular lung water and pulmonary haemodynamics in patients undergoing coronary artery bypass surgery
Anasthesiol Intensivmed Notfallmed Schmerzther 2001; 36(9):545-551

von Spiegel T, Hering R, Hoeft A.
Anesthesia in patients with cardiovascular diseases. 1. General and specific aspects of coronary heart disease and arterial hypertension
Anasthesiol Intensivmed Notfallmed Schmerzther 1999; 34(9):549-574

von Spiegel T, Hoeft A.
we measure plasma volume in intensive care medicine?
Intensive Care Med 1999; 25(11):1212-1214

von Spiegel T, Schroder S, Hoeft A
Anesthesia in patients with cardiovascular diseases
Anasthesiol Intensivmed Notfallmed Schmerzther 1999; 34(11):689-719

Wang F, Seta Y, Baumgarten G, Engel DJ, Sivasubramanian N, Mann DL.
Functional significance of hemodynamic overload-induced expression of leukemia-inhibitory factor in the adult mammalian heart.
Circulation 2001; 103(9):1296-1302

Wartenberg HC, Urban BW, Duch DS
Distinct molecular sites of anaesthetic action: pentobarbital block of human brain sodium channels is alleviated by removal of fast inactivation
Br J Anaesth 1999; 82(1):74-80

Wartenberg HC, Wartenberg JP, Urban BW
sodium channels from human ventricular muscle in planar lipid bilayers Singele
Basic Res Cardiol 2001; 96(6):645-651.

Wartenberg HC, Wartenberg JP, Urban BW
Human cardiac sodium channels are affected by pentobarbital
Eur J Anaesthesiol 2001; 18(5):306-313

Wartenberg HC.
In Process Citation
Anasthesiol Intensivmed Notfallmed Schmerzther 2000; 35(7):460-461

Weber SU, Han N, Packer L.
Ozone: an emerging oxidative stressor to skin
Curr Probl Dermatol 2001; 29:52-61

Weitkamp JH, Stuber F, Bartmann P
Pilot study assessing TNF gene polymorphism as a prognostic marker for disease progression in neonates with sepsis
Infection 2000; 28(2):92-96.

Wenningmann I, Barann M, Vidal AM, Dilger JP
The Effects of isoflurane on acetylcholine receptor channels: 3. Effects of conservative polar-to-nonpolar mutations within the channel pore
Mol Pharmacol 2001; 60(3):584-594

Wenningmann I, Dilger JP
Kinetics of inhibition of non-depolarizing muscle relaxants on the nicotinic acetylcholine receptor
Anasthesiol Intensivmed Notfallmed Schmerzther 2000; 35(9):607-608.

Wenningmann I, Dilger JP
The kinetics of inhibition of nicotinic acetylcholine receptors by (+)-tubocurarine and pancuronium.
Mol Pharmacol 2001; 60(4):790-796

Widman G, Schreiber T, Rehberg B, Hoeft A, Elger CE.
Quantification of depth of anesthesia by nonlinear time series analysis of brain electrical activity.
Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics 2000; 62(4 Pt A):4898-4903.

Wietasch GJ, Mielck F, Scholz M, von Spiegel T, Stephan H, Hoeft A
Bedside assessment of cerebral blood flow by double-indicator dilution technique
Anesthesiology 2000; 92(2):367-375.

Wrigge H, Golisch W, Zinserling J, Sydow M, Almeling G, Burchardi H
Proportional assist versus pressure support ventilation: effects on breathing pattern and respiratory work of patients with chronic obstructive pulmonary disease
Intensive Care Med 1999; 25(8):790-798

Wrigge H, Putensen C.
BIPAP--a forward-looking ventilation mode? Pro
Anasthesiol Intensivmed Notfallmed Schmerzther 2000; 35(11):710-714.

Wrigge H, Putensen C.
is the "best PEEP" in chronic obstructive pulmonary disease?
What Intensive Care Med 2000; 26(9):1167-1169

Wrigge H, Zinserling J, Hering R, Schwalfenberg N, Stuber F, von Spiegel T
Cardiorespiratory effects of automatic tube compensation during airway pressure release ventilation in patients with acute lung injury
Anesthesiology 2001; 95(2):382-389

Wrigge H, Zinserling J, Stuber F, von Spiegel T, Hering R, Wetegrove S et al.
Effects of mechanical ventilation on release of cytokines into systemic circulation in patients with normal pulmonary function
Anesthesiology 2000; 93(6):1413-1417


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