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FORSCHUNGSBERICHT 1999-2001

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Zentrum für Kinderheilkunde Abteilung für Neonatologie

Allgemeine Angaben:
Adenauerallee 119, 53113 Bonn
Telefon: 0228 / 287-3408
Fax: 0228 / 287-3296
eMail: Peter.Bartmann@ukb.uni-bonn.de

Hauptamtliche Professoren:
Prof. Dr. Dr. Peter Bartmann

Wissenschaftliches Personal:
Universitätsstellen
Dr. M. Beck
Frau Dr. D. Behrendt
Frau Dr. S. Benseler
Dr. Th. Bode
Dr. L. Bofferding
Frau Dr. A. Christiansen
Dr. M. Cremer
Dr. J. Dembinski Oberarzt
Frau Dr. M. Eßer
Frau Dr. G. Funck
Frau Dr. A. Grabensee
Dr. A. Heep Oberarzt
Frau U. Heymanns
Dr. Th. Hoppen
Frau Dr. M. Hubert
Dr. N. Kau Oberarzt
Frau Dr. F. Schaaff
Frau Dr. D. Schmidt
J. Schmitt
Frau Dr. C. Schröter
Dr. A. Simon
Frau Dr. S. Stiller
Dr. C. Winter

Forschungsschwerpunkte:
Infektionserkrankungen bei Früh- und Neugeborenen
(Bartmann)

Thrombopoietin und fetale Alloimmunthrombopenie
(Cremer)

Ontogenese der Hämatopoiese und hämatopoietische Wachstumsfaktoren im ZNS
(Dame)

Diagnostik von Infektionserkrankungen
(Dembinski)

Zerebrale Erkrankungen im Neugeborenenalter
(Heep)

Small colony-Varianten von Staphylococcus aureus und koagulasenegativen Staphylokokken
(Schaaff)

B-Zell-Repertoire der Immunantwort bei Frühgeborenen und Säuglingen
(Weitkamp)

Besondere Forschungsförderung:
Infektionserkrankungen bei Früh- und Neugeborenen
(Bartmann, Dembinski, DPC Biermann, Milena)

Molekulare Analyse der Rotavirus-spezifischen B-Lymphozyten - Antwort bei Erwachsenen und Säuglingen
(Weitkamp, DFG)

Small-Colony-Varianten von S. aureus und Koagulase-negativen Staphylokokken
(Schaaff, BONFOR)

Untersuchungen zur biologischen Relevanz des Erythropoietins am zentralen Nervensystem und die Co-Regulation der Erythropoiese durch Hypothalamus und Hypophyse
(Dame, DFG)

Veröffentlichungen:

Bartmann P
Impfungen
In: Palitzsch D: Jugendmedizin, Urban & Fischer, München-Jena, 596 - 601

Bartmann P
Staphylokokkeninfektionen
DGPI-Handbuch, 3. Auflage, Futuramed-Verlag, München, 553 - 560

Bartmann P
Staphylokokkeninfektionen
Therapie-Handbuch, Urban & Schwarzenberg, München, S3-75 - S3-82

Brenner RE, Felger D, Winter C, Christiansen A, Hofmann D, Bartmann P
Effects of dexamethasone on proliferation, chemotaxis, collagen I, and fibronectin-metabolism of human fetal lung fibroblasts
Pediatr Pulmonol 32, 1 - 7

Brinckmann J, Behrens P, Brenner R, Batge B, Tronnier M, Wolff HH
Ehlers-Danlos Syndrom
Hautarzt 50, 257 - 265

Dame C
Thrombopoietin in thrombocytopenias of childhood
Semin Thromb Hemost 27, 215 - 228

Dame C, Albers N, Bartmann P
Candidate gene involved in genital ontogeny in chromosome region 16p13.3
Am J Med Genet 86, 302 - 303

Dame C, Albers N, Hasan C, Bode U, Eigel A, Hansmann M, Brenner R, Bartmann P
Homozygous alpha-thalassaemia and hypospadias - common aetiology or incidental association? Long-term survival of Hb Bart's hydrops syndrome leads to new aspects for counselling of alpha-thalassaemia traits
Eur J Pediatr 158, 217 - 220

Dame C, Bartmann P, Wolber E, Fahnenstich H, Hofmann D, Fandrey J
Erythropoietin gene expression in different areas of the developing human central nervous system
Dev Brain Res 125, 69 - 74

Dame C, Cremer M, Ballmaier M, Bartmann P, Bald R, Schild RL, Fahnentisch H
Concentrations of thrombopoietin and interleukin-11 in the umbilical cord blood of patients with fetal alloimmune thrombocytopenia
Am J Perinatol 18, 335 - 344

Dame C, Hausser I, Geukens J, Brenner RE
Special feature: pathological case of the months
Arch Pediatr Adolesc Med 155, 1275 - 1276

Dembinski J
Thyroid function and adverse outcome - What is the message?
Pediatrics 104, 129 - 130

Dembinski J, Arpe V, Kroll M, Bartmann P, Hieronimi G
Thyroid function in healthy and sick very-low-birth-weight infants - thyrotropin and free thyroxine levels until the sixth week of age
Biol Neonate 80, 210 - 214

Dembinski J, Arpe V, Kroll M, Hieronimi G, Bartmann P
Thyroid function in very low birthweight infants after intravenous administration of the iodinated contrast medium iopromide
Arch Dis Child Fetal Neonatal Ed 82, F215 - F217

Dembinski J, Kaminski M, Kuhl M, Bartmann P
Congenital intrapulmonary bronchogenic cyst in the neonate - perinatal managment
Am J Perinatol 16, 509 - 514

Dembinski J, Pauleit D, Plath H, Bartmann P
Die "spontane" neonatale Nierenvenenthrombose
Praktische Pädiatrie 4, 236 - 240

Ehl S, Gehring B, Pohlandt F
A detailed analysis of changes in serum C-reactive protein levels in neonates treated for bacterial infection
Eur J Pediatr 158, 238 - 242

Fahnenstich H, Steffan J, Kau N, Bartmann P
Fentanyl-induced chest wall rigidity and laryngospasm in preterm and term infants
Crit Care Med 28, 836 - 839

Flieger A, Gongab S, Faigle M, Mayer HA, Kehrer U, Mussotter J, Bartmann P, Neumeister B
Phospholipase A secreted by Legionella pneumophila destroys alveolar surfactant phospholipids
FEMS Mircobiol Lett 188, 129 - 133

Flieger A, Gong S, Faigle M, Deeg M, Bartmann P, Neumeister B
Novel phospholipase A activity secreted by Legionella species
J Bacteriol 182, 1321 - 1327

Gappa M, Berner MM, Hohenschild S, Dammann CE, Bartmann P
Pulmonary function at school-age in surfactant-treated preterm infants
Pediatr Pulmonol 27, 191 - 198

Gehring B, Mornet E, Plath H, Hansmann M, Bartmann P, Brenner RE
Perinatal hypophosphatasia: diagnosis and detection of heterozygote carriers within the family
Clin Genet 56, 313 - 317

Geulen O, Hansmann M, Offergeld R, Kaiser R, Dame C, Hoch J
Maternal and fetal hepatitis C virus exposure by intrauterine transfusion
Lancet 355: 1887 - 1888

Haverkamp F, Noeker M, Gerresheim G, Fahnenstich H
Good prognosis for psychomotor development in survivors with nonimmune hydrops fetalis
BJOG 107, 282 - 284

Haverkamp F, Wölfle J, Aretz M, Kramer A, Hohmann B, Fahnenstich H, Zerres K
Congenital hydrocephalus internus and aqueduct stenosis: aetiology and implications for genetic counselling
Eur J Pediatr 158, 474 - 478

Heep A, Engelskirchen R, Holschneider A, Groneck P
Primary intervention for posthemorrhagic hydrocephalus in very low birthweight infants by ventriculostomy
Childs Nerv Syst 17, 47 - 51

Hoppen T, Eis-Hübinger AM, Schild RL, Enders G, Hansmann M, Rister M, Bartmann P
Intrauterine Herpes-Simplex-Virus-Infektion
Klin Pädiatr 213, 63 - 68

Hoppen T, Elger CE, Bartmann P
Carbamazepine in phenobarbital-nonresponders: experience with ten preterm infants
Eur J Pediatr 160, 444 - 447

Hoppen T, Hofstaetter C, Plath H, Kau N, Bartmann P
Agenesis of the ductus venosus and its correlation to hydrops fetalis
J Perinat Med 28, 69 - 73

Lutjohann D, Bjorkhem I, Locatelli S, Dame C, Schmolling J, von Bergmann K, Fahnenstich H
Cholesterol dynamics in the foetal and neonatal brain as reflected by circulatory levels of 24S-hydroxycholesterol
Acta Paediatr 90, 652 - 657

Meyer C, Witte J, Hildmann A, Hennecke KH, Schunck KU, Maul K, Franke U, Fahnenstich H, Rabe H, Rossi R, Hartmann S, Gortner L
Neonatal screening for hearing disorders in infants at risk: incidence, risk factors, and follow-up
Pediatrics 104, 900 - 904

Pfeiffer KA, Plath H, Reinsberg J, Fahnenstich H, Schmolling J
Maternal and fetal digoxin level in fetofetal transfusion syndrome
Z Geburtshilfe Neonatol 204, 26 - 30

Reinsberg J, Dembinski J, Dorn C, Behrendt D, Bartmann P, van der Ven H
Determination of total interleukin-8 in whole blood after cell lysis
Clin Chem 46, 1387 - 1394

Schild RL, Hoch J, Plath H, Geissen C, Fahnenstich H, Dame C, Hansmann M
Perinatal management of fetal hemolytic disease due to Rh incompatibility combined with fetal alloimmune thrombocytopenia due to HPA-5b incompatibility
Ultrasound Obstet Gynecol 14, 64 - 67

Taillandier A, Zurutuza L, Müller F, Simon-Bouy B, Serre JL, Bird L, Brenner R, Boute O, Cousin J, Gaillard D, Heidemann PH, Steinmann B, Wallot M, Mornet E
Characterization of eleven novel mutations (M45L, R119H, 544delG, G145V, H154Y, C184Y, D289V, 862+5A, 1172delC, R411X, E459K) in the tissue-nonspecific alkaline phosphatase (TNSALP) gene in patients with severe hypophosphatasia
Hum Mutat 13, 171 - 172

Utsch B, Albers N, Dame C, Bartmann P, Lentze MJ, Ludwig M
Homozygous alpha-thalassemia associated with hypospadias: SEA-type deletion does not affect expression of the - 14 gene and loss of the straight theta1-globin gene on 16p13.3 is compensated by its duplicate straight theta2 on chromosome 10
Am J Med Genet 101, 286 - 287

Walch E, Schmidt M, Brenner RE, Emons D, Dame C, Pontz B, Wiestler OD, Bartmann P
Yunis-varon syndrome: evidence for a lysosomal storage disease
Am J Med Genet 95, 157 - 160

Weidenbach M, Brenner R, Rantamaki T, Redel DA
Acute mintral regurgitation due to chordal rupture in a patient with neonatal Marfan syndrome caused by a deletion in exon 29 of the FBN1 gene
Pediatr Cardiol 20, 382 - 385

Weitkamp JH, Stüber F, Bartmann P
Pilot study assessing TNF gene polymorphism as a prognostic marker for progression in neonates with sepsis
Infection 28, 92 - 96

Wolber EM, Dame C, Fahnenstich H, Hofmann D, Bartmann P, Jelkmann W, Fandrey J
Expression of the thrombopoietin gene in human fetal and neonatal tissues
Blood 94, 97 - 105

Zielen S, Wahn V, Bartmann P, Wolf H
Klinische und immunologische Charakteristika des variablen Immundefektsyndroms
Monatsschr Kinderheilkd 147, 594 - 598


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