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FORSCHUNGSBERICHT 1999-2001 | INDEX
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 Pharmazeutisches Institut Pharmazeutische Technologie Endenich
 Pharmazeutisches Institut Klinische Pharmazie
|  Forschungsbericht
Mathematisch-Naturwissenschaftliche Fakultät
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Allgemeine Angaben:
An der Immenburg 4, 53121 Bonn
Telefon: 0228 / 73-9103
Bender W, Staudt M, Tränkle C, Mohr K, Holzgrabe U
Probing the size of a hydrophobic binding pocket within the allosteric site of muscarinic acetylcholine M2-receptors.
Life Sci. 66,1675-1682,2000
Botero Cid HM, Tränkle C, Baumann K, Pick R, Mies-Klomfass E, Kostenis E, Mohr K , Holzgrabe U
Structure-activity relationships in a series of bisquaternary bisphthalimidine derivatives modulating the muscarinic M(2)-receptor allosterically.
J. med. Chem. 43,2155-2164,2000
Franken C, Tränkle C, Mohr K
Testing the specificity of allosteric modulators of muscarinic receptors in phylogenetically closely related histamine H1 receptors.
Naunyn-Schmiedeberg's Arch. Pharmacol. 361,107-112,2000
Holzgrabe U, Bender W, Botero Cid HM, Staudt M, Pick R, Pfletschinger C, Balatkova E, Tränkle C, Mohr K
Ligands for the common allosteric site of acetylcholine M2-receptors: development and application.
Pharm. Acta helv. 74,149-155 (review),2000
Klein CDP, Klingmüller M, Schellinski C, Landmann S, Hauschild S, Heber D, Mohr K, Hopfinger AJ
Synthesis, pharmacological and biophysical characterization, and membrane-interaction QSAR analysis of cationic-amphiphilic model compounds.
J. med. Chem. 42,3874-3888,1999
Klein CD, Tabeteh GF, von Laguna A, Holzgrabe U, Mohr K
Lipophilicity and membrane interactions of cationic-amphiphilic compounds: sytheses and structure-property relationships.
Eur. J. Pharm. Sci. 14,167-175,2001
Li R, Tränkle C, Mohr K, Holzgrabe U
Hexamethonium-type allosteric modulators of the muscarinic receptors bearing lateral dibenzazepine moieties.
Arch. Pharm. (Weinheim). 334,121-124,2001
Lüllmann H, Mohr K
Taschenatlas der Pharmakologie
Thieme Verlag, Stuttgart-New York, 4. Aufl., 2001
Lüllmann H, Mohr K, Wehling M
Pharmakologie und Toxikologie
Thieme Verlag, Stuttgart-New York, 1999
Lüllmann H, Mohr K, Ziegler A, Bieger D
Color Atlas of Pharmacology
Thieme Verlag, Stuttgart-New York, 2. Aufl., 2000
Nassif-Makki T, Tränkle C, Bejeuhr G, Cambareri A, Pfletschinger C, Kostenis E, Mohr K, Holzgrabe U
Bisquaternary ligands of the common allosteric site of M2 acetylcholine receptors: optimization of the distances between the pharmacophoric elements.
J. med. Chem. 42,849-858,1999
Ohnmacht U, Tränkle C, Mohr K, Gmeiner P
[3H]Pramipexole: a selective radioligand for the high afinity dopamine D2 receptor in bovine striatal membranes.
Pharmazie 54,294-297,1999
Phaffendorf M, Batink HD, Tränkle C, Mohr K, van Zwieten P A
Probing the selectivity of allosteric modulators of muscarinic receptors at other G-protein-coupled receptors.
J. Auton. Pharmacol. 20,55-62,2000
Schröter A, Tränkle C, Mohr K
Modes of allosteric interactions with free and [3H]N-methylscopolamine-occupied muscarinic M2 recetors as deduced from buffer-dependent potency shifts.
Naunyn-Schmiedeberg's Arch. Pharmacol. 362,512-519,2000
Thomas C, Ohnmacht U, Zahn K, Mohr K, Tränkle C, Gmeiner P
Ex-chiral pool synthesis and pharmacological aspects of 3-pyrrolidinylisoxazoles.
Pharmazie 54,248-250,1999
Tränkle C, Kostenis E, Mohr K
Muscarinic allosteric modulation: M2/M3 subtype selectivity of gallamine is independent of G-protein coupling specificity.
Naunyn Schmiedeberg's Arch. Pharmacol. 364,172-178, 2001
Tränkle C, Weyand O, Schröter A, Mohr K
Using a radioalloster to test predictions of the cooperativity model for gallamine binding to the allosteric site of muscarinic acetylcholine M2 receptors.
Mol. Pharmacol. 56, 962-965,1999
Zlotos DP, Buller S, Tränkle C, Mohr K
Bisquaternary caracurine V derivatives as allosteric modulators of ligand binding to M2 acetylcholine receptors.
Bioorg. Med. Chem. Lett. 10,2529-2532,2000
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