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FORSCHUNGSBERICHT 1999-2001 | INDEX
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 Institut für Zoophysiologie
 Institut für Mikrobiologie & Biotechnologie
|  Forschungsbericht
Mathematisch-Naturwissenschaftliche Fakultät
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Allgemeine Angaben:
Römerstrasse 164, 53117 Bonn
Telefon: 0228 / 73-4210
Fax: 0228 / 73-4263
eMail: genetik@uni-bonn.de
WWW: http://www.uni-bonn.de/genetik/
Beyer E Willecke K
Gap junction genes and their regulation
In Adv. Mol. Cell Biol. (ed. E.L. Hertzberg), JAI-Press, Stanford, Conn., USA, 30 (2000): 1-30
Caulin C Ware C Magin TM Oshima RG
Keratin 8 and 18 moderate TNF? induced apoptosis of epithelial cells
J. Cell Biol. 149, 17-22 (2000).
C Marcos-Gutiérrez del Mar Lorente M, Pérez C, Schorlemmer C, Ramirez A, Magin T, Vidal M
Loss and gain of function mutations show a polycomb group function for Ring 1A in mice
Development 127, 5093-5100 (2000).
deWit C Roos F Bolz SS Kirchhoff S Krüger O Willecke K Pohl U
Impaired conduction of vasodilation along arterioles in connexin40-deficient mice
Circ. Res. 86 (2000): 649-655
Elias PM Man MQ Feingold K Williams ML Magin T
Normal barrier in heterozygous K10-deficient mice
J. Invest. Dermatol. 114, 395 (2000).
Eugenin E Eckardt D Theis M Willecke K Bennett MVL Saez JC
Microglia at brain stab wounds express connexin43 and in vitro form functional gap junctions after treatment with interferon-Y and tumor necrosis factor a
Proc. Nat. Acad. USA, 27 (2001): 4190-4195
Feigenspan A Teubner B Willecke K Weiler R
Expression of neuronal connexin36 in A II amacrine cells of the mammalian retina
J. Neuroscience 21 (2001): 230-239
Fürst DO Obermann WMJ van der Ven PFM
Structure and assembly of the sarcomeric M band
Reviews in Physiology, Biochemistry and Pharmacology 138 (1999): 163-202
Güldenagel M Ammermüller J Feigenspan A Teubner B Degen J Söhl G Willecke K Weiler R
Visual transmission deficits in mice with targeted disruption of the gap junction gene connexin36
J. Neuroscience 21 (2001): 6034-6044
Güldenagel M Söhl G Traub O Teubner B Plum A Weiler R Willecke K
Expression pattern of connexin genes in mouse retina
J. Comp. Neurol. 425 (2000): 193-201
Hagendorff A Schumacher B Kirchhoff S Lüderitz B Willecke K
Conduction disturbances and increased atrial vulnerability in connexin40 deficient mice analyzed by transesophageal stimulation
Circulation 99 (1999): 1508-1515
Hesse M Franz T Tamai Y Taketo M Magin TM
Targeted deletion of keratins 18 and 19 leads to trophoblast fragility and early embryonic lethality
EMBO J. 19, 5060-5070 (2000).
Hesse M Magin TM Weber K
Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18
J Cell Sci. 114, 2569- 2575 (2001).
Houghton FD Thönnissen E Kidder GM Naus CCG Willecke K Winterhager E
Doubly mutant mice, deficient in connexin32 and -43, show normal prenatal development of organs where the two gap junction proteins are expressed in the same cells
Develop. Genetics 24 (1999): 5-12
Kirchhoff S Kim JS Hagendorff A Thönnissen E Krüger O Lamers WH Willecke K
Abnormal cardiac conduction and morphogenesis in connexin40 and connexin43 double-deficient mice
Circ. Res. 87 (2000): 399-405
Klawitz I Preuss U Scheidtmann KH (2001)
Interaction of SV40 large T antigen with components of the nucleo/cytoskeleton
Int. J. Oncol. 19, 1325-1332
Kögel D Bierbaum H Preuss U Scheidtmann KH (1999)
C-terminal truncation of Dlk/ZIP kinase leads to abrogation of nuclear transport and high apoptotic activity
Oncogene 18, 7212-7218.
Kögel D Reimertz C Mech P Poppe M Engemann H Scheidtmann KH Prehn J H M (2001)
DLK/ZIP Kinase-induced apoptosis in human medulloblastoma cells: requirement of the mitochondrial apoptosis pathway
Brit. J. Cancer 85, 1801-1808
Kögel D Scheidtmann KH Prehn J (2001)
The DAP kinase family of pro- apoptotic proteins: novel players in the apoptotic game
Bioessays, 23, 352- 358.
Kolter T Magin TM Sandhoff K
Biomolecule function: No reliable prediction from cell culture
Traffic 1, 803-804 (2000).
Krüger O Plum A Kim JS Winterhager E Hallas G Kirchhoff S Traub O Lamers WH Willecke K
Defective vascular development in connexin45 deficient miceö.
Development 127 (2000): 4179-4193
Kunzelmann P Schröder W Traub O Steinhäuser C Dermietzel R Willecke K
Late onset and increasing expression of the gap junction protein connexin30 in adult murine brain and longterm cultured astrocytes
Glia 25 (1999): 111-119
Magin TM
Von Mäusen und Menschen: Tiermodelle für humane Keratin- Erkrankungen
Arzneimittelforschung 48, 18-19 (1998).
Magin TM Hesse M Schröder R
Novel insights in intermediate filament function from studies of transgenic and knockout mice
Protoplasma 211, 140-150 (2000).
Magin TM Kaiser HW Leitgeb S Grund C Leigh IM Morley SM Lane EB
Supplementation of a mutant keratin by stable expression of desmin in cultured human EBS keratinocytes
J Cell Sci. 113, 4231-4239 (2000).
Manthey D Banach K Lee CG Kozak CA Traub O Weingart R Willecke K
Intracellular domains of the murine connexin26 and -30 proteins affect dye transfer and electrical conductance of gap junction channels
J. Membrane Biol. 181 (2001): 137-148
Manthey D Bukauskas FF Lee CG Kozak C Willecke K
Molecular cloning and functional expression of the mouse gap junction gene connexin57 in human HeLa cells.
J. Biol. Chem. 274 (1999): 14716-14723
Manthey D Willecke K
Transfection and expression of exogenous connexins in mammalian cells
In Connexin Methods and Protocols (eds. Bruzzone, R., and Giaume, C.).Methods in Molecular Biology 154 (2001): 187-199
Moennikes O Buchmann A Ott T Willecke K Schwarz M
The effect of connexin32 null mutation on hepatocarcinogenesis in different mouse strains
Carcinogenesis 20 (1999): 1379-1382
Moennikes O Buchmann A Romualdi A Ott T Werringloer J Willecke K Schwarz M
Phenobarbital is a promoter of hepatocarcinogenesis in connexin32 wildtype but not in connexin32 null mice
Cancer Research 60 (2000): 5087-5091
Moennikes O Buchmann A Willecke K Traub O Schwarz M
Hepatocarcinogenesis in female mice with mosaic expression of connexin32
Hepatology 32 (2000): 501-506
Niessen H Harz H Bedner P Krämer K Willecke K
Selective permeability of different connexin channels to the second messenger inositol 1.4.5-trisphosphate
J. Cell Science 113 (2000): 1365-1372
Niessen H Willecke K
Strongly decreased gap junctional permeability to inositol 1,4,5-trisphosphate in connexin32 deficient hepatocytes
FEBS Letters 466 (2000): 112-114
Page G Kögel D Rangnekar V Scheidtmann KH (1999)
Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis
Oncogene 18, 7265-7273
Page G Lödige I Kögel D Scheidtmann KH (1999)
AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis
FEBS lett. 462, 187-191.
Peters B Kaiser HW Magin TM
Skin-specific expression of ank-393, a novel ankyrin-3 splice variant
J. Invest. Dermatol. 116, 216-223 (2001).
Peters B Kirfel J Büssow H Vidal M Magin TM
Complete cytolysis and neonatal lethality in keratin 5 knockout mice reveal its fundamental role in skin integrity and in EBS
Mol. Biol. Cell 12, 1775-1789 (2001).
Plum A, Hallas G, Magin T, Dombrowski F, Hagendorff A, Schumacher B, Wolpert C, Kim JS, Lamers WH, Evert M, Meda P, Traub O, Willecke K
Unique and shared functions of different connexins in mice
Current Biology 10 (2000): 1083-1091
Plum A Hallas G Willecke K
Expression of the mouse ocnnexin31 gene is regulated by distinct mechanisms in embryonic stem cells and keratinocytes
Genomics 79 (2001): 24-30
Plum A, Winterhager E, Pesch J, Lautermann J, Hallas G, Rosentreter B, Traub O, Herberhold C, Willecke K
Connexin31-null mutation in mice causes transient placental dysmorphogenesis but does not impair hearing and skin differentiation
Developmental Biology 231 (2001): 334-347
Porter RM Leitgeb S Melton DW Swensson O Eady RAJ Magin TM
Towards a true animal model for epidermolytic hyperkeratosis: phenotypic and morphological findings in mice heterozygous for targetted cytokeratin 10 alleles
J Invest Dermatol. 104, 555 (Abstr). (1995).
Preuss U Kreuzfeld R and Scheidtmann KH. (2000)
The tumor-derived p53 mutant C174Y is a gain-of-function mutant which activates the fos-promoter and enhances colony formation
Int. J. Cancer 88, 162-171.
Reichelt J Büssow H Grund C Magin TM
Formation of a normal epidermis supported by increased stability of keratins 5 and 14 in keratin 10 null mice
Mol. Biol. Cell 12, 1557-1568 (2001).
Reichelt J Doering T Schnetz E Fartasch M Sandhoff K Magin TM
Normal ultrastructure, but altered lipid composition in a mouse model for epidermolytic hyperkeratosis
J. Invest. Dermatol. 113, 329-333 (1999).
Salewski H Bayer T Eidhoff U Preuss U Weggen S Scheidtmann KH (1999)
Increased Oncogenicity of Subclones of SV40 Large T-Induced Neuroectodermal Tumor Cell Lines After Loss of Large T Expression and Concomitant Mutation in p53
Cancer Res. 59: 1980-1986
Schröder R, Warlo I, Herrmann H, van der Ven P, Klasen C, Blümcke I, Mundegar RR, Fürst Goebel HH, Magin TM
Immunogold EM reveals a close association of plectin and the desmin cytoskeleton in human skeletal muscle
Eur. J. Cell Biol. 78, 288-295 (1999).
Schuster N Prowald A Schneider E Scheidtmann KH Montenarh M (1999)
Regulation of p53 mediated transactivation by the beta-subunit of protein kinase CK2
FEBS-Lett. 447, 160-166
Söhl G Eiberger J Jung YT Kozak CA Willecke K
The mouse gap junction gene connexin29 is highly expressed in sciatic nerve and regulated during brain development
Biol. Chem. 382 (2001): 975-978
Söhl G Güldenagel M Beck H Teubner B Traub O Gutiérrez R Heinemann U Willecke K
Expression of connexin genes in hippocampus of kainate treated and kindled rats under conditions of experimental epilepsy
Mol. Brain Res. 83 (2000): 44-51
Söhl G Güldenagel M Traub O Willecke K
Connexin expression in the retina
Brain Research Reviews 32 (2000): 138-145
Söhl G Güldenagel M Traub O Willecke K
Connexin expression in the retina.
Brain Res. Rev. 32 (2000): 138-145.
Söhl G Theis M Brambach S Dahl E Traub O Kidder G Willecke K
A new alternatively spliced transcript of the mouse connexin43 gene is expressed in embryonic stem cells, oocytes and liver
Exp. Cell Res. 266 (2001): 177-186
Sutor B Schmolke C Teubner B Schirmer C Willecke K
Myelination defects and neuronal hyperexcitability in the neocortex of connexin32 deficient mice
Cerebral Cortex 10 (2000): 684-697
Temme A Ott T Dombrowski F Willecke K
The extent of synchronous initiation and termination of DNA synthesis in regenerating mouse liver is dependent on connexin32 expressing gap junctions
J. Hepatology 32 (2000): 627-635
Temme A Ott T Haberberger T Traub O Willecke K
Acute-phase response and circadian expression of connexin26 are not altered in connexin32-deficient mouse liver
Cell Tissue Res. 300 (2000): 111-117
Teubner B, Degen J, Söhl G, Güldenagel M, Bukauskas F, Trexler EB, Verselis VK, De Zeeuw CI, Lee CG, Kozak CA, Dermietzel R, Willecke K
Functional expression of the murine connexin36 gene coding for a neuron specific gap junctional protein
J. Membr. Biol. 176 (2000): 249-262
Teubner B, Odermatt B, Güldenagel M, Söhl G, Degen J, Bukauskas FF, Kronengold J, Verselis VK, Jung YT, Kozak CA, Schilling K, Willecke K
Functional expression of the new gap junction gene connexin47 transcribed in mouse brain and spinal cord neurons
J. Neuroscience 21 (2001): 1117-1126
Theis M, de Wit C, Schlaeger TM, Eckardt D, Krüger O, Döring B, Risau W, Deutsch U, Pohl U, Willecke K
Endothelium-specific replacement of the connexin43 coding region by a LacZ reporter gene
Genesis 29 (2001): 1-13
Theis M Magin TM Plum A Willecke K
General or cell-type specific deletion and replacement of connexin coding DNA in the mouse
Methods 20, 205-218 (2000).
Theis M Magin T Plum A Willecke K
General or cell-type specific deletion and replacement of connexin coding DNA in the mouse
in Methods: A companion to Methods in Enzymology (ed. R. Werner),Academic Press, New York, Methods 20 (1999): 205-218
Theis M Mas C Döring B Krüger O Herrera P Meda P Willecke K
General and conditional replacement of connexin43 coding DNA by a LacZ reporter gene for cell autonomous analysis of expression
Cell Communication and Adhesion 8 (2001): 383-386
Toivola DM Baribault H Magin T Michie SA Bishr Omary M
Simple epithelial keratins are dispensable for cytoprotection in two pancreatitis models
Am. J. Physiol. Gastroint. Liver Physiol. 279, 1343-1354 (2000).
Toivola DM Nieminen M Baribault H Hesse M Magin TM Bishr Omary M Eriksson JE
The liver phenotypes in transgenic mice with absent or altered keratin 8/18 intermediate filaments
Hepatology 34, 1174-1183 (2001).
Valiunas V Manthey D Vogel R Willecke K Weingart R
Biophysical properties of mouse connexin30 gap junction channels studied in transfected human HeLa cells
J. Physiol. 519 (1999): 631-644
Valiunas V Niessen H Willecke K Weingart R
Electrophysiological properties of gap junction channels in hepatocytes isolated from connexin32-deficient and wild-type mice
Eur. J. Physiol. 437 (1999): 846-856
Van der Ven PFM Obermann WMJ Lemke B Gautel M Weber K Fürst DO
Characterization of muscle filamin isoforms suggests a possible role of ?- filamin/ABP-L in sarcomeric Z-disc formation
Cell Motility and the cytoskeleton 45 (2000): 149-162
van Rijen HVM, van Veen TAB, van Kempen MJA, Wilms-Schopman FJG, Potse M, Krueger O, Willecke K, Opthof T, Jongsma H, de Bakker JMT
Impaired conduction in the bundle branches of mouse hearts lacking the gap junction protein connexin40
Circulation 103 (2001): 1591-1598
Verheule S van Batenburg C Coenjaerts F Kirchhoff S Willecke K Jongsma H
Cardiac conduction abnormalities in mice lacking the gap junction protein connexin40
J. Cardiovasc. Electrophysiol. 10 (1999): 1380-1389
Weggen S Preuss U Pietsch T Hilger N Klawitz I Scheidtmann KH Wiestler OD Bayer T (2001)
Identification of amplified genes from SV40 large T antigen-induced rat PNET cell lines by subtractive cDNA analysis and radiation hybrid mapping
Oncogene 20, 2023-2031.
Willecke K
Cardiovascular gap junctions: Functional diversity, complementation and specialization of connexins
In EDHF 2000, ed. P.M. Vanhoutte, Taylor and Francis, London (2001): pp. 14-21.
Willecke K Kirchhoff S Plum A Temme A Thönnissen E Ott T
Biological functions of connexin genes revealed by human genetic defects, dominant negative approaches and targeted deletions in the mouse
Novartis Symposium, Gap Junctions in Health and Disease, ed. G. Cardew, Wiley, Chichester (1999) pp. 76-96
Willecke K Ott T
In Epithelial morphogenesis in development and diseases, ed. W. Birchmeier, Harwood Acad. Publishers (2001): 337-349
Willecke K Temme A Teubner B Ott T
Characterization of targeted connexin32-deficient mice: A model for the human Charcot-Marie-Tooth Disease
Annals of the New York Academy of Sciences 883 (1999): 302-309
Zhuo L Theis M Alvarez-Maya I Bremer M Willecke K Messing A
hGFAP-Cre transgenic mice for manipulation of glial and neuronal functions in vivo
Genesis 31 (2001): 85-94
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